The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study
Open accessAbstract
Introduction: ICU-acquired weakness is thought to mediate physical impairments in survivors of critical illness, but few studies have investigated this thoroughly. The purpose was to investigate differences in post-ICU mortality and physical functioning between patients with and without ICU-acquired weakness at 6 months after ICU discharge. Method: ICU patients, mechanically ventilated ≥2 days, were included in a single-center prospective observational cohort study. ICU-acquired weakness was diagnosed when the average Medical Research Council score was <4 in awake and attentive patients. Post-ICU mortality was recorded until 6 months after ICU discharge; in surviving patients, physical functioning was assessed using the Short-Form Health Survey physical functioning domain. The independent effect of ICU-acquired weakness on post-ICU mortality was analyzed using a multivariable Cox proportional hazards model. The independent effect of ICU-acquired weakness on the physical functioning domain score was analyzed using a multivariable linear regression model. Results: Of the 156 patients included, 80 had ICU-acquired weakness. Twenty-three patients died in the ICU (20 with ICU-acquired weakness); during 6 months follow-up after ICU discharge another 25 patients died (17 with ICU-acquired weakness). Physical functioning domain scores were available for 96 survivors (39 patients with ICU-acquired weakness). ICU-acquired weakness was independently associated with an increase in post-ICU mortality (hazard ratio 3.6, 95% confidence interval, 1.3 to 9.8; P = 0.01) and with a decrease in physical functioning (β: -16.7 points; 95% confidence interval, -30.2 to -3.1; P = 0.02). Conclusion: ICU-acquired weakness is independently associated with higher post-ICU mortality and with clinically relevant lower physical functioning in survivors at 6 months after ICU discharge.
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Cites
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“Alternatively, an increased risk of developing infections may be the result of immune dysfunction secondary to autonomic dysfunction that may accompany ICU-AW [28,29].”
Physical Complications in Acute Lung Injury Survivors: A Two-Year Longitudinal Prospective Study
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Cited by
Vanhorebeek, I., Latronico, N., & Van den Berghe, G. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05944-4 · Cited by 717
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ESPEN guideline on clinical nutrition in hospitalized patients with acute or chronic kidney disease
Fiaccadori, E., Sabatino, A., Barazzoni, R., Carrero, J. J., Cupisti, A., De Waele, E., Jonckheer, J., Singer, P., & Cuerda, C. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.028 · Cited by 277
Looijaard, W. G. P. M., Dekker, I. M., Stapel, S. N., Girbes, A. R. J., Twisk, J. W. R., Oudemans-van Straaten, H. M., & Weijs, P. J. M. (2016) · Critical Care · doi:10.1186/s13054-016-1563-3 · Cited by 218
Miao, Y., Xie, L., Song, J., Cai, X., Yang, J., Ma, X., Chen, S., & Xie, P. (2024) · Physiological Reports · doi:10.14814/phy2.15917 · Cited by 50
“…(ICU-AW), amyotrophic lateral sclerosis (ALS), and muscular atrophy due to inadequate exercise and nutrition, and often results in prolonged hospital stays and higher mortality rates (Cacciani et al., 2020; Mitobe et al., 2019; Riancho et al., 2021; Schweickert et al., 2022; Wieske et al., 2015).”
Background
Metadata
- Authors
- Wieske, L., Dettling-Ihnenfeldt, D. S., Verhamme, C., Nollet, F., van Schaik, I. N., Schultz, M. J., Horn, J., & van der Schaaf, M.
- Venue
- Critical Care
- Published
- 2015-12
- Volume
- 19
- Issue
- 1
- Pages
- 196-196
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2170128875
- Cited by
- 222
- References
- 9
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wieske, L., Dettling-Ihnenfeldt, D. S., Verhamme, C., Nollet, F., van Schaik, I. N., Schultz, M. J., Horn, J., & van der Schaaf, M. (2015). Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study. Critical Care. https://doi.org/10.1186/s13054-015-0937-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
