Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)

Guilhaumou, Romain; Benaboud, Sihem; Bennis, Youssef; Dahyot-Fizelier, Claire; Dailly, Eric; Gandia, Peggy; Goutelle, Sylvain; Lefeuvre, Sandrine; Mongardon, Nicolas; Roger, Claire; Scala-Bertola, Julien; Lemaitre, Florian; Garnier, Marc

doi:10.1186/s13054-019-2378-9

Cited by 543Antibiotics Pharmacokinetics and EfficacySepsis Diagnosis and TreatmentAntibiotic Use and Resistance

Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)

Open access

Guilhaumou, Romain, Benaboud, Sihem, Bennis, Youssef, Dahyot-Fizelier, Claire, Dailly, Eric, Gandia, Peggy, Goutelle, Sylvain, Lefeuvre, Sandrine +5 more·2019·Critical Care

DOI 10.1186/s13054-019-2378-9PMC PMC6441232

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the intensive care unit (ICU). ICU patients present many pathophysiological features that cause pharmacokinetic (PK) and pharmacodynamic (PD) specificities, leading to the risk of underdosage. The French Society of Pharmacology and Therapeutics (SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (SFAR) have joined forces to provide guidelines on the optimization of beta-lactam treatment in ICU patients. METHODS: A consensus committee of 18 experts from the two societies had the mission of producing these guidelines. The entire process was conducted independently of any industry funding. A list of questions formulated according to the PICO model (Population, Intervention, Comparison, and Outcomes) was drawn-up by the experts. Then, two bibliographic experts analysed the literature published since January 2000 using predefined keywords according to PRISMA recommendations. The quality of the data identified from the literature was assessed using the GRADE® methodology. Due to the lack of powerful studies having used mortality as main judgement criteria, it was decided, before drafting the recommendations, to formulate only "optional" recommendations. RESULTS: After two rounds of rating and one amendment, a strong agreement was reached by the SFPT-SFAR guideline panel for 21 optional recommendations and a recapitulative algorithm for care covering four areas: (i) pharmacokinetic variability, (ii) PK-PD relationship, (iii) administration modalities, and (iv) therapeutic drug monitoring (TDM). The most important recommendations regarding βLA administration in ICU patients concerned (i) the consideration of the many sources of PK variability in this population; (ii) the definition of free plasma concentration between four and eight times the Minimal Inhibitory Concentration (MIC) of the causative bacteria for 100% of the dosing interval as PK-PD target to maximize bacteriological and clinical responses; (iii) the use of continuous or prolonged administration of βLA in the most severe patients, in case of high MIC bacteria and in case of lower respiratory tract infection to improve clinical cure; and (iv) the use of TDM to improve PK-PD target achievement. CONCLUSIONS: The experts strongly suggest the use of personalized dosing, continuous or prolonged infusion and therapeutic drug monitoring when administering βLA in critically ill patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s13054-019-2378-9

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Dosing antibiotics according to PK/PD principles and using regimens developed in sepsis/septic shock patients is more likely to achieve effective and safe drug concentrations than using manufacturer's product information.
“Administration of antibiotics using an approach that adheres to PK/PD principles and using dosing regimens developed in patients with sepsis and septic shock is more likely to result in effective and safe drug concentrations compared to use of dosing recommendations provided in the manufacturer’s product information [247].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [247]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
Kumar, A., Roberts, D., Wood, K. E., Light, B., Parrillo, J. E., Sharma, S., Suppes, R., Feinstein, D., Zanotti, S., Taiberg, L., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217961.75225.e9 · Cited by 6,109 · see citing works
State‐of‐the‐Art Clinical Article: Pharmacokinetic/Pharmacodynamic Parameters: Rationale for Antibacterial Dosing of Mice and Men
Craig, W. A. (1998) · Clinical Infectious Diseases · doi:10.1086/516284 · Cited by 2,908 · see citing works
Sepsis in European intensive care units: Results of the SOAP study*
Vincent, J., Sakr, Y. L., Sprung, C. L., Ranieri, V. M., Reinhart, K., Gerlach, H., Moreno, R. P., Carlet, J. M., Gall, J. L., & Payen, D. M. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000194725.48928.3a · Cited by 2,823 · see citing works
GRADE guidelines: 2. Framing the question and deciding on important outcomes
Guyatt, G. H., Oxman, A. D., Kunz, R., Atkins, D., Brozek, J., Vist, G., Alderson, P., Glasziou, P., Falck-Ytter, Y., & Schünemann, H. J. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.09.012 · Cited by 1,911 · see citing works
DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?
Roberts, J. A., Paul, S. K., Akova, M., Bassetti, M., De Waele, J. J., Dimopoulos, G., Kaukonen, K.-M., Koulenti, D., Martin, C., Montravers, P., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu027 · Cited by 1,090 · see citing works
Individualised antibiotic dosing for patients who are critically ill: Challenges and potential solutions.
Roberts, J. A., Abdul-Aziz, M. H., Lipman, J., Mouton, J. W., Vinks, A. A., Felton, T. W., Hope, W. W., Farkas, A., Neely, M. N., Schentag, J. J., et al. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70036-2 · Cited by 1,046 · see citing works
Clinical Importance of Delays in the Initiation of Appropriate Antibiotic Treatment for Ventilator-Associated Pneumonia
Iregui, M. G., Ward, S., Sherman, G., Fraser, V. J., & Kollef, M. H. (2002) · CHEST Journal · doi:10.1378/chest.122.1.262 · Cited by 944 · see citing works
Changes in plasma protein binding have little clinical relevance
Benet, L. Z., & Hoener, B. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.121829 · Cited by 825 · see citing works
The Pharmacodynamics of β‐Lactams
Turnidge, J. D. (1998) · Clinical Infectious Diseases · doi:10.1086/514622 · Cited by 595 · see citing works
Piperacillin-Tazobactam for Pseudomonas aeruginosa Infection: Clinical Implications of an Extended-Infusion Dosing Strategy
Lodise, T. P., Lomaestro, B. M., & Drusano, G. L. (2007) · Clinical Infectious Diseases · doi:10.1086/510590 · Cited by 527 · see citing works
The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients.
Ulldemolins, M., Roberts, J. A., Rello, J., Paterson, D. L., & Lipman, J. (2011) · Clinical Pharmacokinetics · doi:10.2165/11539220-000000000-00000 · Cited by 469 · see citing works
Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections
McKinnon, P. S., Paladino, J. A., & Schentag, J. J. (2008) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.12.009 · Cited by 464 · see citing works
Drug dosing consideration in patients with acute and chronic kidney disease-a clinical update from Kidney Disease: Improving Global Outcomes (KDIGO)
Matzke, G. R., Aronoff, G. R., Atkinson, A. J., Bennett, W. M., Decker, B. S., Eckardt, K.-U., Golper, T., Grabe, D. W., Kasiske, B., Keller, F., et al. (2011) · Kidney International · doi:10.1038/ki.2011.322 · Cited by 462 · see citing works
The effect of pathophysiology on pharmacokinetics in the critically ill patient — Concepts appraised by the example of antimicrobial agents
Blot, S. I., Pea, F., & Lipman, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.07.006 · Cited by 445 · see citing works
Antibiotics in critically ill patients: A systematic review of the pharmacokinetics of β-lactams.
Gonçalves-Pereira, J., & Póvoa, P. (2011) · Critical Care · doi:10.1186/cc10441 · Cited by 408 · see citing works
Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial
Dulhunty, J. M., Roberts, J. A., Davis, J. S., Webb, S. A. R., Bellomo, R., Gomersall, C. D., Shirwadkar, C., Eastwood, G. M., Myburgh, J., Paterson, D. L., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis856 · Cited by 396 · see citing works
Augmented Renal Clearance
Udy, A. A., Roberts, J. A., Boots, R. J., Paterson, D. L., & Lipman, J. (2009) · Clinical Pharmacokinetics · doi:10.2165/11318140-000000000-00000 · Cited by 384 · see citing works
Continuous versus intermittent β-lactam infusion in severe sepsis. A meta-analysis of individual patient data from randomized trials.
Roberts, J. A., Abdul-Aziz, M.-H., Davis, J. S., Dulhunty, J. M., Cotta, M. O., Myburgh, J., Bellomo, R., & Lipman, J. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201601-0024oc · Cited by 379 · see citing works
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
Taccone, F. S., Laterre, P., Dugernier, T., Spapen, H. D., Delattre, I., Wittebole, X., Backer, D. D., Layeux, B., Wallemacq, P. E., Vincent, J., et al. (2010) · Critical Care · doi:10.1186/cc9091 · Cited by 369 · see citing works
Cefepime-induced neurotoxicity: a systematic review
Payne, L. E., Gagnon, D. J., Riker, R. R., Seder, D. B., Glisic, E. K., Morris, J. G., & Fraser, G. L. (2017) · Critical Care · doi:10.1186/s13054-017-1856-1 · Cited by 347 · see citing works
The Clinical Relevance of Plasma Protein Binding Changes
Roberts, J. A., Pea, F., & Lipman, J. (2012) · Clinical Pharmacokinetics · doi:10.1007/s40262-012-0018-5 · Cited by 341 · see citing works
MIC-based dose adjustment: facts and fables
Mouton, J. W., Muller, A. E., Cantón, R., et al. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx427 · Cited by 329 · see citing works
Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: A systematic review and meta-analysis of randomised trials.
Vardakas, K. Z., Voulgaris, G. L., Maliaros, A., Samonis, G., & Falagas, M. E. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30615-1 · Cited by 327 · see citing works
Too much of a good thing: a retrospective study of β-lactam concentration–toxicity relationships
Imani, S., Buscher, H., Marriott, D., Gentili, S., & Sandaradura, I. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx209 · Cited by 321 · see citing works
Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis
Abdul-Aziz, M. H., Sulaiman, H., Nor, M. B. M., Rai, V., Wong, K. K., Hasan, M. S., Rahman, A. N. A., Jamal, J., Wallis, S. C., Lipman, J., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4188-0 · Cited by 309 · see citing works
European Medicines Agency Guideline on Bioanalytical Method Validation: What More Is There to Say?
Smith, G. (2012) · Bioanalysis · doi:10.4155/bio.12.44 · Cited by 308 · see citing works
Killing and regrowth of bacteria in vitro: a review.
Craig, W. A., & Ebert, S. C. (1990) · PubMed · Cited by 301 · see citing works
Clinical Pharmacodynamics of Meropenem in Patients with Lower Respiratory Tract Infections
Li, C., Du, X., Kuti, J. L., & Nicolau, D. P. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00294-06 · Cited by 289 · see citing works
Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model
Mouton, J. W., & den Hollander, J. G. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.5.931 · Cited by 275 · see citing works
Protein Binding: Do We Ever Learn?
Zeitlinger, M. A., Derendorf, H., Mouton, J. W., Cars, O., Craig, W. A., Andes, D. R., & Theuretzbacher, U. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01433-10 · Cited by 249 · see citing works
Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy
Seyler, L., COTTON, F. J., Taccone, F. S., Backer, D. D., Macours, P., Vincent, J., & Jacobs, F. (2011) · Critical Care · doi:10.1186/cc10257 · Cited by 232 · see citing works
Protein Binding of β-Lactam Antibiotics in Critically Ill Patients: Can We Successfully Predict Unbound Concentrations?
Wong, G., Briscoe, S., Adnan, S., McWhinney, B. C., Ungerer, J. P. J., Lipman, J., & Roberts, J. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00951-13 · Cited by 230 · see citing works
A systematic review on clinical benefits of continuous administration of β-lactam antibiotics*
Roberts, J. A., Webb, S. A. R., Paterson, D. L., Ho, K. M., & Lipman, J. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a0054d · Cited by 225 · see citing works
Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort study
Huttner, A. C., von Dach, E., Renzoni, A., Huttner, B. D., Affaticati, M., Pagani, L., Daali, Y., Pugin, J., Karmime, A., Fathi, M., et al. (2015) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.12.017 · Cited by 221 · see citing works
Performance of the Cockcroft-Gault and Modification of Diet in Renal Disease Equations in Estimating GFR in Ill Hospitalized Patients
Poggio, E. D., Nef, P. C., Wang, X., Greene, T., Lente, F. V., Dennis, V. W., & Hall, P. M. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.04.023 · Cited by 217 · see citing works
Empirical antimicrobial therapy of septic shock patients: Adequacy and impact on the outcome*
Léone, M., Bourgoin, A., Cambon, S., Dubuc, M., Albanèse, J., & Martin, C. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050298.59549.4a · Cited by 209 · see citing works
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia
Kollef, M. H., Chastre, J. E., Clavel, M., Restrepo, M. I., Michiels, B., Kaniga, K., Cirillo, I., Kimko, H. H. C., & Redman, R. L. (2012) · Critical Care · doi:10.1186/cc11862 · Cited by 208 · see citing works
Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients
Udy, A. A., Roberts, J. A., Shorr, A. F., Boots, R. J., & Lipman, J. (2013) · Critical Care · doi:10.1186/cc12544 · Cited by 207 · see citing works
Assessment of renal function in recently admitted critically ill patients with normal serum creatinine
Hoste, E. A. J., Damen, J., Vanholder, R. C., Lameire, N. H., Delanghe, J., den Hauwe, K. V., & COLARDYN, F. A. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh707 · Cited by 205 · see citing works
Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy
Fugate, J. E., Kalimullah, E. A., Hocker, S. E., Clark, S. L., Wijdicks, E. F. M., & Rabinstein, A. A. (2013) · Critical Care · doi:10.1186/cc13094 · Cited by 203 · see citing works
Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients.
Veiga, R. P., & Paiva, J.-A. (2018) · Critical Care · doi:10.1186/s13054-018-2155-1 · Cited by 203 · see citing works
Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial
Waele, J. J. D., Carrette, S., Carlier, M., Stove, V. V., Boelens, J., Claeys, G., Leroux‐Roels, I., Hoste, E. A. J., Depuydt, P. O., Decruyenaere, J. M. A., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-013-3187-2 · Cited by 198 · see citing works
Evidence for the involvement of GABAA receptor blockade in convulsions induced by cephalosporins
Sugimoto, M., Uchida, I., Mashimo, T., et al. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00188-6 · Cited by 194 · see citing works
Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review
Sime, F. B., Roberts, M. S., Peake, S., Lipman, J., & Roberts, J. A. (2012) · Annals of Intensive Care · doi:10.1186/2110-5820-2-35 · Cited by 184 · see citing works
High Cefepime Plasma Concentrations and Neurological Toxicity in Febrile Neutropenic Patients with Mild Impairment of Renal Function
Lamoth, F., Buclin, T., Pascual, A., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01595-08 · Cited by 182 · see citing works
Meropenem by Continuous Versus Intermittent Infusion in Ventilator-Associated Pneumonia due to Gram-Negative Bacilli
Lorente, L., Lorenzo, L., Martin, M. M. I. D. O., Jiménez, A., & Mora, M. L. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1g467 · Cited by 180 · see citing works
Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: Direct measurement of unbound drug concentrations to achieve appropriate drug exposures.
Wong, G., Briscoe, S., McWhinney, B., Ally, M., Ungerer, J., Lipman, J., & Roberts, J. A. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky314 · Cited by 169 · see citing works
Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats
Sarro, A. D., Ammendola, D., Zappalà, M., et al. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.1.232 · Cited by 168 · see citing works
Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort
Abdul-Aziz, M. H., Lipman, J., Akova, M., Bassetti, M., Waele, J. J. D., Dimοpoulos, G., Dulhunty, J. M., Kaukonen, K., Koulenti, D., Martin, C., et al. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv288 · Cited by 167 · see citing works
Population Pharmacokinetics and Pharmacodynamics of Continuous versus Short-Term Infusion of Imipenem-Cilastatin in Critically Ill Patients in a Randomized, Controlled Trial
Sakka, S. G., Glauner, A. K., Bulitta, J. B., Kinzig‐Schippers, M., Pfister, W., Drusano, G. L., & Sörgel, F. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01318-06 · Cited by 159 · see citing works
Simultaneous Determination of 12 β-Lactam Antibiotics in Human Plasma by High-Performance Liquid Chromatography with UV Detection: Application to Therapeutic Drug Monitoring
Verdier, M., Tribut, O., Tattevin, P., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00533-11 · Cited by 157 · see citing works
Renal replacement therapy in adult and pediatric intensive care
Vinsonneau, C., Allain-Launay, E., Blayau, C., Darmon, M., du Cheyron, D., Gaillot, T., Honore, P. M., Javouhey, E., Krummel, T., Lahoche, A., et al. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0093-5 · Cited by 151 · see citing works
Impact of Dosing Intervals on Activity of Gentamicin and Ticarcillin Against Pseudomonas aeruginosa in Granulocytopenic Mice
Gerber, A., Craig, W. A., Brugger, H. P., et al. (1983) · The Journal of Infectious Diseases · doi:10.1093/infdis/147.5.910 · Cited by 150 · see citing works
Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study
Huwyler, T., Lenggenhager, L., Abbas, M., et al. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.01.005 · Cited by 142 · see citing works
Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization
Sime, F. B., Udy, A. A., & Roberts, J. A. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.06.002 · Cited by 135 · see citing works
Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review
Alobaid, A. S., Hites, M., Lipman, J., Taccone, F. S., & Roberts, J. A. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.01.009 · Cited by 131 · see citing works
Elevated β-lactam concentrations associated with neurological deterioration in ICU septic patients.
Beumier, M., Casu, G. S., Hites, M., Wolff, F., COTTON, F. J., Vincent, J., Jacobs, F., & Taccone, F. S. (2015) · PubMed · Cited by 128 · see citing works
Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion
Lorente, L., Jiménez, A., Martin, M. M. I. D. O., Iribarren, J. L., Jiménez, J. J., & Mora, M. L. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2008.10.025 · Cited by 127 · see citing works
Population Pharmacokinetics of High-Dose, Prolonged-Infusion Cefepime in Adult Critically Ill Patients with Ventilator-Associated Pneumonia
Nicasio, A. M., Ariano, R. E., Zelenitsky, S. A., Kim, A., Crandon, J. L., Kuti, J. L., & Nicolau, D. P. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01141-08 · Cited by 123 · see citing works
Systematic Comparison of the Population Pharmacokinetics and Pharmacodynamics of Piperacillin in Cystic Fibrosis Patients and Healthy Volunteers
Bulitta, J. B., Duffull, S. B., Kinzig‐Schippers, M., Holzgrabe, U., Stephan, U., Drusano, G. L., & Sörgel, F. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01477-06 · Cited by 120 · see citing works
Optimal exposures of ceftazidime predict the probability of microbiological and clinical outcome in the treatment of nosocomial pneumonia
Muller, A. E., Punt, N. C., & Mouton, J. W. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks468 · Cited by 120 · see citing works
Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection
Li, C., Kuti, J. L., Nightingale, C. H., et al. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki243 · Cited by 113 · see citing works
Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial
Udy, A. A., Dulhunty, J. M., Roberts, J. A., Davis, J. S., Webb, S. A. R., Bellomo, R., Gomersall, C. D., Shirwadkar, C., Eastwood, G. M., Myburgh, J., et al. (2017) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.12.022 · Cited by 109 · see citing works
Evaluation by Monte Carlo Simulation of the Pharmacokinetics of Two Doses of Meropenem Administered Intermittently or as a Continuous Infusion in Healthy Volunteers
Krueger, W. A., Bulitta, J. B., Kinzig‐Schippers, M., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1881-1889.2005 · Cited by 106 · see citing works
Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients
Quinton, M.-C., Bodeau, S., Kontar, L., Zerbib, Y., Maizel, J., Slama, M., Masmoudi, K., Lemaire‐Hurtel, A., & Bennis, Y. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00654-17 · Cited by 104 · see citing works
Self-citation
Neurological Adverse Effects Attributable to β-Lactam Antibiotics: A Literature Review
Deshayes, S., Coquerel, A., & Verdon, R. (2017) · Drug Safety · doi:10.1007/s40264-017-0578-2 · Cited by 104 · see citing works
Prospective monitoring of cefepime in intensive care unit adult patients
Chapuis, T. M., Giannoni, É., Majcherczyk, P. A., Chioléro, R. L., Schaller, M., Berger, M. M., Bolay, S., Decosterd, L. A., Bugnon, D., & Moreillon, P. (2010) · Critical Care · doi:10.1186/cc8941 · Cited by 102 · see citing works
Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients
Schleibinger, M., Steinbach, C. L., Töpper, C., Kratzer, A., Liebchen, U., Kees, F., Salzberger, B., & Kees, M. G. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12636 · Cited by 101 · see citing works
Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units
Roos, J. F., Bulitta, J. B., Lipman, J., & Kirkpatrick, C. M. J. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl349 · Cited by 101 · see citing works
Prolonged infusion versus intermittent boluses of β-lactam antibiotics for treatment of acute infections: a meta-analysis
Teo, J. Q.-M., Liew, Y., Lee, W., & Kwa, A. L. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.01.027 · Cited by 98 · see citing works
Pharmacokinetics and pharmacodynamics of meropenem in critically ill patients
Kitzes‐Cohen, R., Farin, D., Piva, G., & Myttenaere-Bursztein, S. A. D. (2002) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(01)00474-5 · Cited by 97 · see citing works
Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection
Jongh, R. D., Hens, R., Basma, V., et al. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm467 · Cited by 90 · see citing works
Cefepime Versus Cefpirome: The Importance of Creatinine Clearance
Lipman, J., Wallis, S. C., & Boots, R. J. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000077077.54084.b0 · Cited by 86 · see citing works
A simple ultra-high-performance liquid chromatography-high resolution mass spectrometry assay for the simultaneous quantification of 15 antibiotics in plasma
Lefeuvre, S., Bois-Maublanc, J., Hocqueloux, L., et al. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.09.014 · Cited by 86 · see citing works
Self-citation
Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials
Tamma, P. D., Putcha, N., Suh, Y. D., Arendonk, K. J. V., & Rinke, M. L. (2011) · BMC Infectious Diseases · doi:10.1186/1471-2334-11-181 · Cited by 85 · see citing works
In vitro pharmacodynamics of ceftazidime against Pseudomonas aeruginosa isolates from cystic fibrosis patients
Manduru, M., Mihm, L. B., White, R. L., et al. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.9.2053 · Cited by 82 · see citing works
Comparison of clinical cure rates in adults with ventilator-associated pneumonia treated with intravenous ceftazidime administered by continuous or intermittent infusion: A retrospective, nonrandomized, open-label, historical chart review
Lorente, L., Jiménez, A., Palmero, S., Jiménez, J. J., Iribarren, J. L., Santana, M. C., Martin, M. M. I. D. O., & Mora, M. L. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.11.003 · Cited by 80 · see citing works
Dosing Nomograms for Attaining Optimum Concentrations of Meropenem by Continuous Infusion in Critically Ill Patients with Severe Gram-Negative Infections: a Pharmacokinetics/Pharmacodynamics-Based Approach
Pea, F., Viale, P., Cojutti, P. G., & Furlanut, M. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01291-12 · Cited by 78 · see citing works
Elimination of the piperacillin/tazobactam combination during continuous venovenous haemofiltration and haemodiafiltration in patients with acute renal failure
Valtonen, M. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.6.881 · Cited by 77 · see citing works
Concentration-Effect Relationship of Ceftazidime Explains Why the Time above the MIC Is 40 Percent for a Static Effect In Vivo
Mouton, J. W., Punt, N. C., & Vinks, A. A. T. M. M. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01586-06 · Cited by 77 · see citing works
Development and validation of a measurement procedure based on ultra-high performance liquid chromatography-tandem mass spectrometry for simultaneous measurement of β-lactam antibiotic concentration in human plasma
Rigo-Bonnin, R. F., Ribera, A., Arbiol‐Roca, A., et al. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.03.009 · Cited by 77 · see citing works
Continuous Cefazolin Infusion To Treat Bone and Joint Infections: Clinical Efficacy, Feasibility, Safety, and Serum and Bone Concentrations
Zeller, V., Durand, F., Kitzis, M.-D., Lhotellier, L., Ziza, J.-M., Mamoudy, P., & Desplaces, N. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00389-08 · Cited by 73 · see citing works
Pharmacokinetics and Pharmacodynamics of Cephalosporins in Cerebrospinal Fluid
Lutsar, I., & Friedland, I. R. (2000) · Clinical Pharmacokinetics · doi:10.2165/00003088-200039050-00003 · Cited by 70 · see citing works
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis
Asín‐Prieto, E., Rodríguez‐Gascón, A., Trocóniz, I. F., Soraluce, A., Maynar, J., Sánchez‐Izquierdo, J. Á., & Isla, A. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt304 · Cited by 69 · see citing works
Population Pharmacokinetics of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
Isla, A., Rodríguez‐Gascón, A., Trocóniz, I. F., Bueno, L., Solinís, M. Á., Maynar, J., Sánchez‐Izquierdo, J. Á., & Pedraz, J. L. (2008) · Clinical Pharmacokinetics · doi:10.2165/00003088-200847030-00003 · Cited by 68 · see citing works
Piperacillin concentration in relation to therapeutic range in critically ill patients – a prospective observational study
Zander, J., Döbbeler, G., Nagel, D., Maier, B., Scharf, C., Huseyn‐Zada, M., Jung, J., Frey, L., Vogeser, M., & Zöller, M. (2016) · Critical Care · doi:10.1186/s13054-016-1255-z · Cited by 65 · see citing works
Population Pharmacokinetics at Two Dose Levels and Pharmacodynamic Profiling of Flucloxacillin
Landersdorfer, C. B., Kirkpatrick, C. M. J., Kinzig‐Schippers, M., Bulitta, J. B., Holzgrabe, U., Drusano, G. L., & Sörgel, F. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01410-06 · Cited by 64 · see citing works
Influence of Renal Function on the Pharmacokinetics of Piperacillin/Tazobactam in Intensive Care Unit Patients During Continuous Venovenous Hemofiltration
Arzuaga, A., Maynar, J., Rodríguez‐Gascón, A., Isla, A., Corral, E., Fonseca, F., Sánchez‐Izquierdo, J. Á., Rello, J., Canut, A., & Pedraz, J. L. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004269796 · Cited by 64 · see citing works
Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients
Fournier, A., Eggimann, P., Pagani, J., Revelly, J., Decosterd, L. A., Marchetti, O., Pannatier, A., Voirol, P., & Que, Y. (2015) · Burns · doi:10.1016/j.burns.2015.01.001 · Cited by 62 · see citing works
Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies)
Ichaï, C., Vinsonneau, C., Souweine, B., Armando, F., Canet, E., Clec’h, C., Constantin, J., Darmon, M., Duranteau, J., Gaillot, T., et al. (2016) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2016.03.004 · Cited by 55 · see citing works
Pharmacokinetic/pharmacodynamic modeling can help guide targeted antimicrobial therapy for nosocomial gram-negative infections in critically ill patients
Mohr, J., Wanger, A. R., & Rex, J. H. (2004) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2003.09.010 · Cited by 54 · see citing works
Cefepime pharmacodynamics in patients with extended spectrum β-lactamase (ESBL) and non-ESBL infections
Lee, S. Y., Kuti, J. L., & Nicolau, D. P. (2006) · Journal of Infection · doi:10.1016/j.jinf.2006.09.004 · Cited by 54 · see citing works
Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions
Lipš, M., Šiller, M., Strojil, J., Urbánek, K., Balík, M., & Suchánková, H. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.05.011 · Cited by 51 · see citing works
Antibiotic dose optimization in critically ill patients
Cotta, M. O., Roberts, J. A., & Lipman, J. (2015) · Medicina Intensiva · doi:10.1016/j.medin.2015.07.009 · Cited by 51 · see citing works
The Pharmacokinetics of Prophylactic Antibiotics in Trauma
REED, R. L., Ericsson, C. D., Wu, A. H. B., et al. (1992) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199201000-00005 · Cited by 49 · see citing works
What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?
Alobaid, A. S., Brinkmann, A., Frey, O. R., et al. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv412 · Cited by 49 · see citing works
Association between hypoalbuminemia and mortality among subjects treated with ertapenem versus other carbapenems: prospective cohort study
Zusman, O., Farbman, L., Tredler, Z., Daitch, V., Lador, A., Leibovici, L., & Paul, M. (2014) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.08.003 · Cited by 48 · see citing works
Continuous Infusion Versus Intermittent Bolus of Beta-Lactams in Critically Ill Patients with Respiratory Infections: A Systematic Review and Meta-analysis
Lee, Y. R., Miller, P. D., Alzghari, S. K., Blanco, D. D., Hager, J. D., & Kuntz, K. S. (2017) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-017-0439-5 · Cited by 48 · see citing works
Preparing and administering injectable antibiotics: How to avoid playing God
Longuet, P., Lecapitaine, A., Cassard, B., Batista, R., Gauzit, R., Lesprit, P., Haddad, R., Vanjak, D., & Diamantis, S. (2016) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2016.01.010 · Cited by 47 · see citing works
Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients
Dhaese, S. A. M., Roberts, J. A., Carlier, M., Verstraete, A., Stove, V. V., & Waele, J. J. D. (2017) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2017.12.015 · Cited by 46 · see citing works
Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures
Carlier, M., Noe, M., Roberts, J. A., Stove, V. V., Verstraete, A., Lipman, J., & Waele, J. J. D. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku195 · Cited by 44 · see citing works
Prolonged versus Intermittent Infusion of β-Lactams for the Treatment of Nosocomial Pneumonia: A Meta-Analysis
Lal, A. A., Jaoude, P., & El-Solh, A. (2016) · Infection and Chemotherapy · doi:10.3947/ic.2016.48.2.81 · Cited by 44 · see citing works
Obesity-related physiological changes and their pharmacokinetic consequences
Cho, S., Yoon, I., & Kim, D. (2013) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-013-0073-4 · Cited by 43 · see citing works
Therapeutic drug monitoring when using cefepime in continuous renal replacement therapy: seizures associated with cefepime
Smith, N., Freebairn, R., Park, M. A. J., Wallis, S. C., Roberts, J. A., & Lipman, J. (2012) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01773-8 · Cited by 42 · see citing works
Prospective Determination of Serum Ceftazidime Concentrations in Intensive Care Units
Aubert, G., Carricajo, A., Coudrot, M., Guyomarch, S., Auboyer, C., & Zéni, F. (2010) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e3181e60ca6 · Cited by 40 · see citing works
High target attainment for β-lactam antibiotics in intensive care unit patients when actual minimum inhibitory concentrations are applied
Woksepp, H., Hällgren, A., Borgström, S., et al. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2832-4 · Cited by 39 · see citing works
Delivering precision antimicrobial therapy through closed-loop control systems
Rawson, T. M., O’Hare, D., Herrero, P., Sharma, S., Moore, L. S. P., de Barra, E., Roberts, J. A., Gordon, A. C., Hope, W. W., Georgiou, P., et al. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx458 · Cited by 39 · see citing works
Fluctuation of the volume of distribution of amikacin and its effect on once-daily dosage and clearance in a seriously ill patient
Botha, F. J., van der Bijl, P., Seifart, H. I., et al. (1996) · Intensive Care Medicine · doi:10.1007/bf01712162 · Cited by 36 · see citing works
Standard dosing of piperacillin and meropenem fail to achieve adequate plasma concentrations in ICU patients
Petersson, J., Giske, C. G., & Eliasson, E. (2016) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12808 · Cited by 36 · see citing works
Population pharmacokinetics of four β-lactams in critically ill septic patients comedicated with amikacin
Delattre, I., Musuamba, F. T., Jacqmin, P., Taccone, F. S., Laterre, P., Verbeeck, R. K., Jacobs, F., & Wallemacq, P. E. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.03.030 · Cited by 35 · see citing works
Stability of generic brands of meropenem reconstituted in isotonic saline.
Carlier, M., Stove, V., Verstraete, A., et al. (2015) · PubMed · Cited by 34 · see citing works
Plasma and peritoneal concentration following continuous infusion of cefotaxime in patients with secondary peritonitis
Séguin, P., Verdier, M., Chanavaz, C., Engrand, C., Laviolle, B., Donnio, P.-Y., & Mallédant, Y. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn522 · Cited by 34 · see citing works
Unbound fraction of ertapenem in intensive care unit patients
Liebchen, U., Kratzer, A., Wicha, S. G., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku226 · Cited by 34 · see citing works
Clinical Outcome and Antimicrobial Therapeutic Drug Monitoring for the Treatment of Infections in Acute Burn Patients
Machado, A. S., de Oliveira, M. S., Sanches, C., da Silva, C. V., Gomez, D. D. S., Gemperli, R., Santos, S. R. C. J., & Levin, A. S. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.06.008 · Cited by 34 · see citing works
Tolerability of high-dose ceftriaxone in CNS infections: a prospective multicentre cohort study
Turnier, P. L., Navas, D., Garot, D., Guimard, T., Bernard, L., Tattevin, P., Vandamme, Y. M., Hoff, J., Chiffoleau, A., Dary, M., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky553 · Cited by 34 · see citing works
Kinetics of Imipenem Distribution into the Peritoneal Fluid of Patients with Severe Peritonitis Studied by Microdialysis
Dahyot‐Fizelier, C., Lefeuvre, S., Laksiri, L., et al. (2010) · Clinical Pharmacokinetics · doi:10.2165/11319370-000000000-00000 · Cited by 33 · see citing works
Self-citation
Pharmacokinetics of Ertapenem in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis or Hemodiafiltration
Eyler, R. F., Vilay, A. M., Nader, A. M., Heung, M., Pleva, M. R., Sowinski, K. M., DePestel, D. D., Sörgel, F., Kinzig, M., & Mueller, B. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02090-12 · Cited by 32 · see citing works
Clinical Outcomes of Extended Versus Intermittent Infusion of Piperacillin/Tazobactam in Critically Ill Patients: A Prospective Clinical Trial
Fan, S. G., Shum, H., Cheng, W., et al. (2016) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1875 · Cited by 31 · see citing works
Ceftazidime dosage regimen in intensive care unit patients: from a population pharmacokinetic approach to clinical practice via Monte Carlo simulations
Georges, B., Conil, J., Ruiz, S., Seguin, T., Cougot, P., Fourcade, O., Houin, G., & Saivin, S. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04117.x · Cited by 30 · see citing works
Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration
Roberts, J. A., Udy, A. A., Bulitta, J. B., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku177 · Cited by 30 · see citing works
Plasma, urine and skin pharmacokinetics of cefepime in burns patients
Sampol, E. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.2.315 · Cited by 28 · see citing works
Adequacy of High-Dose Cefepime Regimen in Febrile Neutropenic Patients with Hematological Malignancies
Sime, F. B., Roberts, M. S., Tiong, I. S., Gardner, J. H., Lehman, S., Peake, S., Hahn, U., Warner, M. S., & Roberts, J. A. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00389-15 · Cited by 26 · see citing works
Are interstitial fluid concentrations of meropenem equivalent to plasma concentrations in critically ill patients receiving continuous renal replacement therapy?
Varghese, J. M., Jarrett, P., Wallis, S. C., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku413 · Cited by 26 · see citing works
Dose modulation: A new concept of antibiotic therapy in the critically ill patient?
Gonçalves-Pereira, J., & Paiva, J.-A. (2013) · Journal of Critical Care · doi:10.1016/j.jcrc.2012.11.018 · Cited by 25 · see citing works
Evaluation of Meropenem Penetration into Cerebrospinal Fluid in Patients with Meningitis After Neurosurgery
Zhang, Y., Zhang, J., Chen, Y., Yu, J., Cao, G., Wu, X., Chen, M., Wu, J., & Zhao, X. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.11.040 · Cited by 25 · see citing works
Dosing of antibacterial agents in obese adults: does one size fit all?
Payne, K. D., & Hall, R. G. (2014) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2014.912942 · Cited by 24 · see citing works
Use of high-performance liquid chromatography (HPLC) to monitor β-lactam plasma concentrations during the treatment of endocarditis
Tattevin, P., Tribut, O., Arvieux, C., et al. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2004.01030.x · Cited by 20 · see citing works
Low Flucloxacillin Concentrations in a Patient With Central Nervous System Infection
Abdul-Aziz, M. H., McDonald, C., McWhinney, B. C., Ungerer, J. P. J., Lipman, J., & Roberts, J. A. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028014540610 · Cited by 20 · see citing works
Antibiotic use and good practice in 314 French hospitals: The 2010 SPA2 prevalence study
Alfandari, S., Robert, J., Pean, Y., et al. (2015) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2015.10.001 · Cited by 19 · see citing works
Microdialysis in the Neurocritical Care Unit
Kitagawa, R. S., Yokobori, S., Mazzeo, A. T., et al. (2013) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2013.02.002 · Cited by 18 · see citing works
Cefepime in intensive care unit patients: Validation of a population pharmacokinetic approach and influence of covariables
Georges, B., Jm, C., Seguin, T., Dieye, E., Cougot, P., Decun, J. F., Lavit, M., Samii, K., Houin, G., & Saivin, S. (2008) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp46157 · Cited by 17 · see citing works
Evaluation of an alternative extended-infusion piperacillin–tazobactam dosing strategy for the treatment of gram-negative infections
Winstead, E. M., Ratliff, P. D., Hickson, R. P., et al. (2016) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-016-0334-1 · Cited by 12 · see citing works
Pharmacokinetics of free ertapenem in critically ill septic patients: intermittent versus continuous infusion.
Breilh, D., Fleureau, C., Gordien, J.-B., Joanes-Boyau, O., Texier-Maugein, J., Rapaport, S., Boselli, E., Janvier, G., & Saux, M. (2011) · PubMed · Cited by 10 · see citing works
How Robust are our Methods of Detecting Impaired Glomerular Filtration Rate in the Intensive Care Unit?
Joshi, S., Murari, T., Narula, A., et al. (2008) · Medical Journal Armed Forces India · doi:10.1016/s0377-1237(08)80049-4 · Cited by 3 · see citing works

Flagged first, then by citations

Sorted by citations

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
Thabet, P., Joshi, A., MacDonald, E., Hutton, B., Cheng, W., Stevens, A., & Kanji, S. (2021) · PLOS ONE · doi:10.1371/journal.pone.0244966 · Cited by 29 · see citing works

Authors: Guilhaumou, R., Benaboud, S., Bennis, Y., Dahyot-Fizelier, C., Dailly, E., Gandia, P., Goutelle, S., Lefeuvre, S., Mongardon, N., Roger, C., Scala-Bertola, J., Lemaitre, F., & Garnier, M.
Affiliations: Assistance Publique Hôpitaux de Marseille (FR)
Hôpital Cochin (FR)
Centre Hospitalier Universitaire Amiens-Picardie (FR)
Centre Hospitalier Universitaire de Toulouse (FR)
Inserm (FR)
Centre hospitalier universitaire d'Orléans (FR)
Centre Hospitalier Universitaire Henri-Mondor (FR)
Centre Hospitalier Universitaire de Nîmes (FR)
Hôpital Pontchaillou (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author: Garnier, Marc
ORCID: Guilhaumou, Romain
Benaboud, Sihem
Bennis, Youssef
Gandia, Peggy
Goutelle, Sylvain
Mongardon, Nicolas
Roger, Claire
Garnier, Marc
Venue: Critical Care
Publisher: Springer Science and Business Media LLC
Published: 2019-03-29
Volume: 23
Issue: 1
Pages: 104-104
ISSN: 1364-8535 (ISSN-L)
DOI: 10.1186/s13054-019-2378-9
PMC: PMC6441232
OpenAlex: W2929478224
Cited by: 543
References: 134
Citations by year: 2026: 72 · 2025: 80 · 2024: 92 · 2023: 79 · 2022: 86 · 2021: 73 · 2020: 44 · 2019: 17
FWCI: 34.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: Critical Care (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
HAL (submittedVersion)
HAL AMU (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Keywords: beta-lactam antibiotics, critically ill patients, intensive care unit, individualized dosing, pharmacokinetic variability, PK/PD relationship, therapeutic drug monitoring, continuous infusion, prolonged infusion, minimum inhibitory concentration, lower respiratory tract infection, antibiotic dosing optimization, expert consensus recommendations, bacteriological response, clinical cure, pharmacokinetic/pharmacodynamic target attainment
MeSH terms: Anti-Bacterial Agents, beta-Lactamases, France, Glomerular Filtration Rate, Humans, Intensive Care Units, Serum Albumin, Societies, Medical, Societies, Pharmaceutical, Critical Illness, Treatment Outcome, Drug Monitoring, Guidelines as Topic, Drug Dosage Calculations

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review