The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome
Open accessAbstract
Average genome size is an important, yet often overlooked, property of microbial communities. We developed MicrobeCensus to rapidly and accurately estimate average genome size from shotgun metagenomic data and applied our tool to 1,352 human microbiome samples. We found that average genome size differs significantly within and between body sites and tracks with major functional and taxonomic differences. In the gut, average genome size is positively correlated with the abundance of Bacteroides and genes related to carbohydrate metabolism. Importantly, we found that average genome size variation can bias comparative analyses, and that normalization improves detection of differentially abundant genes.
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Cites
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Yin, X., Jiang, X.-T., Chai, B., Li, L., Yang, Y., Cole, J. R., Tiedje, J. M., & Zhang, T. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty053 · Cited by 710
Nayfach, S., Rodriguez-Mueller, B., Garud, N., & Pollard, K. S. (2016) · Genome Research · doi:10.1101/gr.201863.115 · Cited by 470
Self-citationAdaptive Evolution within Gut Microbiomes of Healthy People
Zhao, S., Lieberman, T. D., Poyet, M., Kauffman, K. M., Gibbons, S. M., Groussin, M., Xavier, R. J., & Alm, E. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.03.007 · Cited by 434
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Tanca, A., Abbondio, M., Palomba, A., Fraumene, C., Manghina, V., Cucca, F., Fiorillo, E., & Uzzau, S. (2017) · Microbiome · doi:10.1186/s40168-017-0293-3 · Cited by 172
Metadata
- Authors
- Nayfach, S., & Pollard, K. S.
- Venue
- Genome Biology
- Published
- 2015-03-25
- Volume
- 16
- Issue
- 1
- Pages
- 51-51
- ISSN
- 1465-6906 (ISSN-L)
- OpenAlex
- W2094116491
- Cited by
- 359
- References
- 16
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nayfach, S., & Pollard, K. S. (2015). Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome. Genome Biology. https://doi.org/10.1186/s13059-015-0611-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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