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Cited by 8RNA and protein synthesis mechanismsGene Regulatory Network AnalysisBioinformatics and Genomic Networks

Co-regulation of translation in protein complexes

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Siwiak, Marlena, Zielenkiewicz, Piotr·2015·Biology Direct
DOI 10.1186/s13062-015-0048-7PMC PMC4409705
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Abstract

BACKGROUND: Co-regulation of gene expression has been known for many years, and studied widely both globally and for individual genes. Nevertheless, most analyses concerned transcriptional control, which in case of physically interacting proteins and protein complex subunits may be of secondary importance. This research is the first quantitative analysis that provides global-scale evidence for translation co-regulation among associated proteins. RESULTS: By analyzing the results of our previous quantitative model of translation, we have demonstrated that protein production rates plus several other translational parameters, such as mRNA and protein abundance, or number of produced proteins from a gene, are well concerted between stable complex subunits and party hubs. This may be energetically favorable during synthesis of complex building blocks and ensure their accurate production in time. In contrast, for connections with regulatory particles and date hubs translational co-regulation is less visible, indicating that in these cases maintenance of accurate levels of interacting particles is not necessarily beneficial. CONCLUSIONS: Similar results obtained for distantly related model organisms, Saccharomyces cerevisiae and Homo sapiens, suggest that the phenomenon of translational co-regulation applies to the variety of living organisms and concerns many complex constituents. This phenomenon was also observed among the set of functionally linked proteins from Escherichia coli operons. This leads to the conclusion that translational regulation of a protein should always be studied with respect to the expression of its primary interacting partners.

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  • Literature broadly has reported common co-regulation of genes in protein complexes at both transcription and translational levels.

    “This is a unique finding since literature broadly has reported common co-regulation of genes in protein complexes at both transcription and translational levels96–102.”

    From EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery (2026) · cites this paper as [97]

    The Background says transcriptional co-regulation of protein-complex genes was well studied, and the Conclusions report translational co-regulation among interacting proteins. But the Abstract Background calls this the first quantitative global-scale evidence for translational co-regulation among associated proteins, so the claim overstates how broadly earlier literature had reported it at both levels. Our copy provides no page numbers for these sections. (LLM, conf=0.86)

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References 44 · Cited by 8

Research works printed but not linked: 32

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Authors
Siwiak, M., & Zielenkiewicz, P.
Affiliations
Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
Corresponding author
Zielenkiewicz, Piotr
ORCID
Zielenkiewicz, Piotr
Venue
Biology Direct
Publisher
Springer Science and Business Media LLC
Published
2015-04-25
Volume
10
Issue
1
Pages
18-18
ISSN
1745-6150 (ISSN-L)
DOI
10.1186/s13062-015-0048-7
PMC
PMC4409705
OpenAlex
W2001178029
Cited by
8
References
44
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2019: 1 · 2018: 1 · 2015: 1
FWCI
0.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Biology Direct (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
protein complexes, protein-protein interaction, translational regulation, protein production rate, mRNA levels, protein abundance, hub proteins, operon, Saccharomyces cerevisiae, human, Escherichia coli
MeSH terms
Computer Simulation, Escherichia coli, Gene Expression Regulation, Humans, Protein Binding, Proteins, RNA, Messenger, Saccharomyces cerevisiae, Transcription, Genetic, Protein Biosynthesis, Computational Biology, Protein Interaction Mapping

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