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Why the Central Dogma: on the nature of the great biological exclusion principle
Open accessAbstract
Abstract The Central Dogma of molecular biology posits that transfer of information from proteins back to nucleic acids does not occur in biological systems. I argue that the impossibility of reverse translation is indeed a major, physical exclusion principle that emerges due to the transition from the digital information carriers, nucleic acids, to analog information carriers, proteins, which involves irreversible suppression of the digital information. Reviewers This article was reviewed by Itai Yanai, Martin Lercher and Frank Eisenhaber.
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Ten proteinogenic amino acids were abiotically synthesized.
“Most likely, ten proteinogenic amino acids were abiotically synthesized [67].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [67]
The passages on amino acids in “Irreversibility of the digital to analog transition” (page unavailable) discuss their role in translation, not their abiotic synthesis. Searches for the claim and for prebiotic amino-acid synthesis found no passage stating that ten proteinogenic amino acids were abiotically synthesized. (LLM, conf=0.75)
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Research works printed but not linked: 15
- Feynman R. The character of physical law. Cambridge, MA: MIT Press; 1964.
- Crick F. Central dogma of molecular biology. Nature. 1970;227(5258):561–3. · DOI · Paper page
- Crick FH. On protein synthesis. Symp Soc Exp Biol. 1958;12:138–63.
- Haykin S, Van Veen B. Signals and systems. 2nd ed. Hoboke, NJ: John Wiley and Sons; 2003.
- Ling J, Reynolds N, Ibba M. Aminoacyl-tRNA synthesis and translational quality control. Annu Rev Microbiol. 2009;63:61–78. · DOI
- Finkelstein AV, Ptitsyn OB. Protein physics: a course of lectures. NY: Academic Press; 2002.
- Drummond DA, Wilke CO. Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell. 2008;134(2):341–52. · DOI
- Uversky VN. The multifaceted roles of intrinsic disorder in protein complexes. FEBS Lett. 2015. · DOI
- Costa FF. Non-coding RNAs: meet thy masters. Bioessays. 2010;32(7):599–608. · DOI
- Crick FH. The origin of the genetic code. J Mol Biol. 1968;38(3):367–79. · DOI · Paper page
- Bernhardt HS. The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)(a). Biol Direct. 2012;7:23. · DOI
- Aravind L, Mazumder R, Vasudevan S, Koonin EV. Trends in protein evolution inferred from sequence and structure analysis. Curr Opin Struct Biol. 2002;12:392–9. · DOI · Paper page
- Been MD. Molecular biology. Versatility of self-cleaving ribozymes. Science. 2006;313(5794):1745–7. · DOI
- Chien P, Weissman JS, DePace AH. Emerging principles of conformation-based prion inheritance. Annu Rev Biochem. 2004;73:617–56. · DOI
- Koonin EV. Does the central dogma still stand? Biol Direct. 2012;7:27. · DOI
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Chatterjee, S., & Yadav, S. (2019) · Life · doi:10.3390/life9010025 · Cited by 80
Metadata
- Authors
- Koonin, E. V.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Koonin, Eugene V.
- ORCID
- Koonin, Eugene V.
- Venue
- Biology Direct
- Published
- 2015-09-16
- Volume
- 10
- Issue
- 1
- Pages
- 52-52
- ISSN
- 1745-6150 (ISSN-L)
- PMC
- PMC4573691
- OpenAlex
- W1901263135
- Cited by
- 54
- References
- 0
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 13 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Biology Direct (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- U.S. National Library of Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Keywords
- central dogma, reverse translation, nucleic acids, proteins, information suppression, irreversibility
- MeSH terms
- Molecular Biology, Nucleic Acids, Proteins, Protein Biosynthesis
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