Koonin, Eugene V.

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature

Genomics and Phylogenetic StudiesGenetic Associations and Epidemiology

Cited by 24,216

In vivo genome editing using Staphylococcus aureus Cas9

Ran, F. A., Cong, L., Yan, W. X., Scott, D. A., Gootenberg, J. S., Kriz, A. J., Zetsche, B., Shalem, O., Wu, X., Makarova, K. S., et al. (2015) · Nature

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 2,687

Diversity, classification and evolution of CRISPR-Cas systems

Koonin, E. V., Makarova, K. S., & Zhang, F. (2017) · Current Opinion in Microbiology

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 1,423

Comparative genomics of the lactic acid bacteria.

Makarova, K., Slesarev, A., Wolf, Y., Sorokin, A., Mirkin, B., Koonin, E., Pavlov, A., Pavlova, N., Karamychev, V., Polouchine, N., et al. (2006) · Proceedings of the National Academy of Sciences

Probiotics and Fermented FoodsGenomics and Phylogenetic Studies

Cited by 1,391

Orthologs, Paralogs, and Evolutionary Genomics

Koonin, E. V. (2005) · Annual Review of Genetics

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 1,323

A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

Makarova, K. S., Grishin, N. V., Shabalina, S. A., Wolf, Y. I., & Koonin, E. V. (2006) · Biology Direct

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 1,199

Classification and evolution of P-loop GTPases and related ATPases

Leipe, D. D., Wolf, Y. I., Koonin, E. V., & Aravind, L. (2002) · Journal of Molecular Biology

RNA and protein synthesis mechanismsGenomics and Phylogenetic Studies

Cited by 1,148

Horizontal gene transfer in prokaryotes: Quantification and classification

Koonin, E. V., Makarova, K. S., & Aravind, L. (2001) · Annual Review of Microbiology

Genomics and Phylogenetic StudiesBacterial Genetics and Biotechnology

Cited by 1,126

A minimal gene set for cellular life derived by comparison of complete bacterial genomes

Mushegian, A. R., & Koonin, E. V. (1996) · Proceedings of the National Academy of Sciences

Genomics and Phylogenetic StudiesBacterial Genetics and Biotechnology

Cited by 916

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., & Koonin, E. V. (1997) · The FASEB Journal

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 746

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., & Chumakov, P. M. (2004) · Science

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 731

Comparative genomics, minimal gene-sets and the last universal common ancestor

Koonin, E. V. (2003) · Nature Reviews Microbiology

Genomics and Phylogenetic StudiesOrigins and Evolution of Life

Cited by 661

Functional and evolutionary implications of gene orthology

Gabaldón, T., & Koonin, E. V. (2013) · Nature Reviews Genetics

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 643

Origin of a substantial fraction of human regulatory sequences from transposable elements

Jordan, I. K., Rogozin, I. B., Glazko, G. V., & Koonin, E. V. (2003) · Trends in Genetics

Chromosomal and Genetic VariationsGenomics and Chromatin Dynamics

Cited by 577

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

Smargon, A. A., Cox, D. B. T., Pyzocha, N. K., Zheng, K., Slaymaker, I. M., Gootenberg, J. S., Abudayyeh, O. A., Essletzbichler, P., Shmakov, S., Makarova, K. S., et al. (2017) · Molecular Cell

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 575

Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

Porter, J. A., Ekker, S. C., Park, W.-J., von Kessler, D. P., Young, K. E., Chen, C.-H., Ma, Y., Woods, A. S., Cotter, R. J., Koonin, E. V., et al. (1996) · Cell

Hedgehog Signaling Pathway StudiesWnt/β-catenin signaling in development and cancer

Cited by 533

Classification and evolution of type II CRISPR-Cas systems

Chylinski, K., Makarova, K. S., Charpentier, E., & Koonin, E. V. (2014) · Nucleic Acids Research

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 498

Origins and evolution of CRISPR-Cas systems

Koonin, E. V., & Makarova, K. S. (2019) · Philosophical Transactions of the Royal Society B: Biological Sciences

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 494

Origin of first cells at terrestrial, anoxic geothermal fields

Mulkidjanian, A. Y., Bychkov, A. Y., Dibrova, D. V., Galperin, M. Y., & Koonin, E. V. (2012) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifePaleontology and Stratigraphy of Fossils

Cited by 447

Remarkable Interkingdom Conservation of Intron Positions and Massive, Lineage-Specific Intron Loss and Gain in Eukaryotic Evolution

Rogozin, I. B., Wolf, Y. I., Sorokin, A. V., Mirkin, B. G., & Koonin, E. V. (2003) · Current Biology

Chromosomal and Genetic VariationsGenomics and Phylogenetic Studies

Cited by 445

Mammalian Retrovirus-like Protein PEG10 Packages Its Own MRNA and Can Be Pseudotyped for MRNA Delivery

Segel, M., Lash, B., Song, J., Ladha, A., Liu, C. C., Jin, X., Mekhedov, S. L., Macrae, R. K., Koonin, E. V., & Zhang, F. (2021) · Science

RNA Interference and Gene DeliveryVirus-based gene therapy research

Cited by 423

Evolution of Aminoacyl-tRNA Synthetases—Analysis of Unique Domain Architectures and Phylogenetic Trees Reveals a Complex History of Horizontal Gene Transfer Events

Wolf, Y. I., Aravind, L., Grishin, N. V., & Koonin, E. V. (1999) · Genome Research

RNA and protein synthesis mechanismsGenomics and Phylogenetic Studies

Cited by 410

The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases

Altae-Tran, H., Kannan, S., Demircioglu, F. E., Oshiro, R., Nety, S. P., McKay, L. J., Dlakić, M., Inskeep, W. P., Makarova, K. S., Macrae, R. K., et al. (2021) · Science

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 407

On the origin of genomes and cells within inorganic compartments

Koonin, E. V., & Martin, W. (2005) · Trends in Genetics

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 406