The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Synovitis in osteoarthritis: current understanding with therapeutic implications
Open accessAbstract
Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging phenotypes demonstrating complex and multi-tissue pathologies involving cartilage, subchondral bone and (increasingly recognized) inflammation of the synovium. The synovium may show significant changes, even before visible cartilage degeneration has occurred, with infiltration of mononuclear cells, thickening of the synovial lining layer and production of inflammatory cytokines. The combination of sensitive imaging modalities and tissue examination has confirmed a high prevalence of synovial inflammation in all stages of OA, with a number of studies demonstrating that synovitis is related to pain, poor function and may even be an independent driver of radiographic OA onset and structural progression. Treating key aspects of synovial inflammation therefore holds great promise for analgesia and also for structure modification. This article will review current knowledge on the prevalence of synovitis in OA and its role in symptoms and structural progression, and explore lessons learnt from targeting synovitis therapeutically.
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Citations
Cites
The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
Wojdasiewicz, P., Poniatowski, Ł. A., & Szukiewicz, D. (2014) · Mediators of Inflammation · doi:10.1155/2014/561459 · Cited by 1,608
Cited by
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis
Faust, H. J., Zhang, H., Han, J., Wolf, M. T., Jeon, O. H., Sadtler, K., Peña, A. N., Chung, L., Maestas, D. R., Tam, A. J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134091 · Cited by 260
Potential efficacy of dendritic cell immunomodulation in the treatment of osteoarthritis
Alahdal, M., Zhang, H., Huang, R., Sun, W., Deng, Z., Duan, L., Ouyang, H., & Wang, D. (2021) · Rheumatology · doi:10.1093/rheumatology/keaa745 · Cited by 50
Caliogna, L., Berni, M., Torriani, C., Mancuso, M. E., Di Minno, M. N. D., Brancato, A. M., Jannelli, E., Mosconi, M., & Pasta, G. (2024) · Haemophilia · doi:10.1111/hae.15097 · Cited by 39
Zhou, S., Wen, H., Cai, W., Zhang, Y., & Li, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.099 · Cited by 16
Metadata
- Authors
- Mathiessen, A., & Conaghan, P. G.
- Venue
- Arthritis Research & Therapy
- Published
- 2017-02-02
- Volume
- 19
- Issue
- 1
- Pages
- 18-18
- ISSN
- 1478-6354 (ISSN-L)
- 1478-6362
- OpenAlex
- W2584503597
- Cited by
- 1,065
- References
- 1
- FWCI
- 49.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mathiessen, A., & Conaghan, P. G. (2017). Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Research & Therapy. https://doi.org/10.1186/s13075-017-1229-9
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