Genetic drivers of progression in Alzheimer’s disease are distinct from disease risk

Cohen, Celeste E.; Fernandez, Shane; Yaman, Umran; Ehyaei, Ahmad R.; Kodosaki, Eleftheria; Askarova, Aydan; Porter, Tenielle; O’Brien, Eleanor; Australian Imaging Biomarkers and Lifestyle Study; Alzheimer’s Disease Neuroimaging Initiative; Maruff, Paul; Nott, Alexi; Hardy, John A.; Laws, Simon M.; A. Salih, Dervis; Shoai, Maryam

doi:10.1186/s13195-026-02036-1

Genetic drivers of progression in Alzheimer’s disease are distinct from disease risk

BACKGROUND: Recent trials in Alzheimer’s disease (AD) demonstrate encouraging outcomes. These trials target risk mechanisms identified through genetic analysis whilst directly aiming to reduce progression rates. Evidence from other neurodegenerative diseases suggests the genetics of progression i…