Human mesenchymal stem cells maintain their phenotype, multipotentiality, and genetic stability when cultured using a defined xeno-free human plasma fraction
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Acceptable intervals for periodic testing to confirm the genetic and phenotypic stability of the cell system can be highly case-dependent.
“It is recommended to develop acceptable intervals for periodic testing to confirm the genetic and phenotypic stability of the cell system; these, however, can be highly case-dependent (Blazquez-Prunera et al., 2017; Daily et al., 2017; Meza-Zepeda et al., 2008).”
From Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0) (2021) · cites this paper as Blazquez-Prunera et al., 2017
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“In primary human MSCs, Blázquez-Prunera et al. (2017) demonstrated that primary human MSCs preserved their native characteristics in culture by maintaining typical morphology and functional properties, including their ability to differentiate into adipogenic, osteogenic, and chondrogenic lineages.”
- Authors
- Blázquez-Prunera, A., Díez, J. M., Gajardo, R., & Grancha, S.
- Venue
- Stem Cell Research & Therapy
- Published
- 2017-04-27
- Volume
- 8
- Issue
- 1
- ISSN
- 1757-6512
- PMC
- PMC5408419
- Cited by
- 55
- References
- 0
- Language
- en
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