The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration
Open accessAbstract
Transcription factors regulate gene expression through binding to specific enhancer sequences. Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3), and V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA) are transcription factors critical for beta cell development and maturation. NEUROG3 is expressed in endocrine progenitor cells and controls islet differentiation and regeneration. PDX1 is essential for the development of pancreatic exocrine and endocrine cells including beta cells. PDX1 also binds to the regulatory elements and increases insulin gene transcription. Likewise, MAFA binds to the enhancer/promoter region of the insulin gene and drives insulin expression in response to glucose. In addition to those natural roles in beta cell development and maturation, ectopic expression of PDX1, NEUROG3, and/or MAFA has been successfully used to reprogram various cell types into insulin-producing cells in vitro and in vivo, such as pancreatic exocrine cells, hepatocytes, and pluripotent stem cells. Here, we review biological properties of PDX1, NEUROG3, and MAFA, and their applications and limitations for beta cell regenerative approaches. The primary source literature for this review was acquired using a PubMed search for articles published between 1990 and 2017. Search terms include diabetes, insulin, trans-differentiation, stem cells, and regenerative medicine.
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Cites
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Cited by
Transcription factor-mediated differentiation of human iPSCs into neurons
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Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
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Statins and risk of type 2 diabetes: mechanism and clinical implications
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Employing core regulatory circuits to define cell identity
Almeida, N., Chung, M. W. H., Drudi, E. M., Engquist, E. N., Hamrud, E., Isaacson, A., Tsang, V. S. K., Watt, F. M., & Spagnoli, F. M. (2021) · The EMBO Journal · doi:10.15252/embj.2020106785 · Cited by 49
Metadata
- Authors
- Zhu, Y., Liu, Q., Zhou, Z., & Ikeda, Y.
- Venue
- Stem Cell Research & Therapy
- Published
- 2017-11-02
- Volume
- 8
- Issue
- 1
- Pages
- 240-240
- ISSN
- 1757-6512 (ISSN-L)
- OpenAlex
- W2766208502
- Cited by
- 323
- References
- 44
- FWCI
- 15.67
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhu, Y., Liu, Q., Zhou, Z., & Ikeda, Y. (2017). PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration. Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-017-0694-z
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