The DOI matches its Crossref record; 248 of the 248 references it cites were found in a registry or an index.
Neural stem cell therapy for subacute and chronic ischemic stroke
Open accessAbstract
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading cause of death and disability. Clinically, extensive injury from ischemic stroke results from ischemia-reperfusion (IR), which is accompanied by inflammation, blood-brain barrier (BBB) damage, neural cell death, and extensive tissue loss. Tissue plasminogen activator (tPA) is still the only US Food and Drug Administration-approved clot-lysing agent. Whereas the thrombolytic role of tPA within the vasculature is beneficial, the effects of tPA (in a non-thrombolytic role) within the brain parenchyma have been reported as harmful. Thus, new therapies are needed to reduce the deleterious side effects of tPA and quickly facilitate vascular repair following stroke. The Stroke Treatment Academic Industry Roundtable (STAIR) recommends that stroke therapies "focus on drugs/devices/treatments with multiple mechanisms of action and that target multiple pathways". Thus, based on multifactorial ischemic cascades in various stroke stages, effective stroke therapies need to focus on targeting and ameliorating early IR injury as well as facilitating angiogenesis, neurogenesis, and neurorestorative mechanisms following stroke. This review will discuss the preclinical perspectives of NSC transplantation as a promising treatment for neurovascular injury and will emphasize both the subacute and chronic phase of ischemic stroke.
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“Although until recently it was thought that the central nervous system (CNS) was fixed and incapable of regeneration, nowadays it is well-established that neural plasticity persists throughout life in humans [214], [215].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [214]
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Metadata
- Authors
- Boese, A. C., Le, Q.-S. E., Pham, D., Hamblin, M. H., & Lee, J.-P.
- Affiliations
- Tulane University (US)
- Corresponding author
- Lee, Jean-Pyo
- Venue
- Stem Cell Research & Therapy
- Published
- 2018-06-13
- Volume
- 9
- Issue
- 1
- Pages
- 154-154
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC5998588
- OpenAlex
- W2808420239
- Cited by
- 205
- References
- 247
- Citations by year
- 2026: 4 · 2025: 28 · 2024: 19 · 2023: 46 · 2022: 38 · 2021: 30 · 2020: 19 · 2019: 15 · 2018: 5
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Louisiana Clinical and Translational Science Center
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- neural stem cell transplantation, ischemic stroke, ischemia-reperfusion injury, subacute stroke, chronic stroke, tissue plasminogen activator, blood-brain barrier disruption, neuroinflammation, angiogenesis, neurogenesis, neurovascular injury, stroke treatment
- MeSH terms
- Brain Ischemia, Chronic Disease, Humans, Tissue Plasminogen Activator, Stroke, Stem Cell Transplantation
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