Cited by 62Angiogenesis and VEGF in CancerNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Paracrine control of vascularization and neurogenesis by neurotrophins

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Emanueli, Costanza, Schratzberger, Peter, Kirchmair, Rudolf, Madeddu, Paolo·2003·British Journal of Pharmacology

Abstract

The neuronal system plays a fundamental role in the maturation of primitive embryonic vascular network by providing a paracrine template for blood vessel branching and arterial differentiation. Furthermore, postnatal vascular and neural regeneration cooperate in the healing of damaged tissue. Neurogenesis continues in adulthood although confined to specific brain regions. Following ischaemic insult, neural staminal cells contribute towards the healing process through the stimulation of neurogenesis and vasculogenesis. Evidence indicates that nerves and blood vessels exert a reciprocal control of their own growth by paracrine mechanisms. For instance, guidance factors, including vascular endothelial growth factor A (VEGF‐A) and semaphorins, which share the ability of binding neuropilin receptors, play a pivotal role in the tridimensional growth pattern of arterial vessels and nerves. Animal models and clinical studies have demonstrated a role of VEGF‐A in the pathogenesis of ischaemic and diabetic neuropathies. Further, supplementation with VEGF‐A ameliorates neuronal recovery by exerting protective effects on nerves and stimulating reparative neovascularization. Human tissue kallikrein, a recently discovered angiogenic and arteriogenic factor, accelerates neuronal recovery by stimulating the growth of vasa nervorum. Conversely, the neurotrophin nerve growth factor, known to regulate neuronal survival and differentiation, is now regarded as a stimulator of angiogenesis and arteriogenesis. These results indicate that angiogenesis and neurogenesis are paracrinally regulated by growth factors released by endothelial cells and neurons. Supplementation of these growth factors, alone or in combination, could benefit the treatment of ischaemic diseases and neuropathies. British Journal of Pharmacology (2003) 140, 614–619. doi:10.1038/sj.bjp.0705458

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Authors
Emanueli, C., Schratzberger, P., Kirchmair, R., & Madeddu, P.
Affiliations
  • Istituto Nazionale Biostrutture e Biosistemi (IT)
  • Innsbruck Medical University (AT)
  • University of Sassari (IT)
Corresponding author
Madeddu, Paolo
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
2003-10
Volume
140
Issue
4
Pages
614-619
ISSN
  • 0007-1188 (ISSN-L)
  • 1476-5381
OpenAlex
W2034028717
Cited by
62
References
42
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 9
FWCI
0.21
Type
journal article
Language
en
Open access
Locations
  • British Journal of Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Explore Bristol Research (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
neurotrophins, paracrine signaling, angiogenesis, arteriogenesis, neurogenesis, nerve growth factor, VEGF-A, semaphorins, kallikrein, vasa nervorum, diabetic neuropathy, neurovascular regeneration, vascular branching, growth factor supplementation
MeSH terms
Humans, Nerve Growth Factors, Neurons, Neovascularization, Physiologic, Paracrine Communication

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