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Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells
Open accessAbstract
Background: COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19. Objectives: To determine whether human umbilical cord mesenchymal stem cell infusion may be effective and safe for the treatment of severe COVID-19. Methods: Patients with severe COVID-19 were randomly divided into 2 groups: the standard treatment group and the standard treatment plus hUC-MSC infusion group. The incidence of progression from severe to critical illness, 28-day mortality, clinical symptom improvement, time to clinical symptom improvement, hematologic indicators including C-reactive protein, lymphocyte number, and interleukin 6, and imaging changes were observed and compared between the two groups. Measurements and main results: The incidence of progression from severe to critical illness and the 28-day mortality rate were 0 in the hUC-MSC treatment group, while 4 patients in the control group deteriorated to critical condition and received invasive ventilation; 3 of them died, and the 28-day mortality rate was 10.34%. In the hUC-MSC treatment group, the time to clinical improvement was shorter than that in the control group. Clinical symptoms of weakness and fatigue, shortness of breath, and low oxygen saturation obviously improved beginning on the third day of stem cell infusion and reached a significant difference on day 7. CRP and IL-6 levels were significantly lower from day 3 of infusion, the time for the lymphocyte count to return to the normal range was significantly faster, and lung inflammation absorption was significantly shorter on CT imaging in the hUC-MSC group than in the control group. Conclusions: Intravenous transplantation of hUC-MSCs is a safe and effective method that can be considered a salvage and priority treatment option for severe COVID-19. Trial registration: Chinese Clinical Trial Registration; ChiCTR2000031494; Registered on 2 April 2020; http:// www.medresman.org
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Self-citationA pneumonia outbreak associated with a new coronavirus of probable bat origin
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Self-citationLa certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Stem cell-based therapy for human diseases
Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01134-4 · Cited by 1,074
Dabrowska, S., Andrzejewska, A., Janowski, M., & Lukomska, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.591065 · Cited by 282
Mazini, L., Ezzoubi, M., & Malka, G. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02006-w · Cited by 267
Siemieniuk, R. A., Bartoszko, J. J., Díaz Martinez, J. P., Kum, E., Qasim, A., Zeraatkar, D., Izcovich, A., Mangala, S., Ge, L., Han, M. A., et al. (2021) · BMJ · doi:10.1136/bmj.n2231 · Cited by 79
Self-citationWang, Y., Yu, H., Tang, H., Zhu, R., Shi, Y., Xu, C., Li, Y., Wang, H., Chen, Y., Shen, P., et al. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.07.007 · Cited by 3
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Metadata
- Authors
- Shu, L., Niu, C., Li, R., Huang, T., Wang, Y., Huang, M., Ji, N., Zheng, Y., Chen, X., Shi, L., Wu, M., Deng, K., Wei, J., Wang, X., Cao, Y., Yan, J., & Feng, G.
- Venue
- Stem Cell Research & Therapy
- Published
- 2020-08-18
- Volume
- 11
- Issue
- 1
- Pages
- 361-361
- ISSN
- 1757-6512 (ISSN-L)
- OpenAlex
- W3078961638
- Cited by
- 303
- References
- 38
- FWCI
- 26.45
- Type
- journal article
- Language
- en
- Open access
- gold
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