The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells
Open accessAbstract
Background: Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive application prospects over the years. Despite performing similar functions, exosomes from different origins present heterogeneous characteristics and components; however, the relative study remains scarce. Lacking of a valuable reference, researchers select source cells for exosome studies mainly based on accessibility and personal preference. Methods: In this study, exosomes secreted by MSCs derived from different tissues were isolated, by ultracentrifugation, and proteomics analysis was performed. A total of 1014 proteins were detected using a label-free method. Results: Bioinformatics analysis revealed their shared function in the extracellular matrix receptor. Bone marrow MSC-derived exosomes showed superior regeneration ability, and adipose tissue MSC-derived exosomes played a significant role in immune regulation, whereas umbilical cord MSC-derived exosomes were more prominent in tissue damage repair. Conclusions: This study systematically and comprehensively analyzes the human MSC-derived exosomes via proteomics, which reveals their potential applications in different fields, so as to provide a reference for researchers to select optimal source cells in future exosome-related studies.
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Cites
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Kern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370
Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model
Furuta, T., Miyaki, S., Ishitobi, H., Ogura, T., Kato, Y., Kamei, N., Miyado, K., Higashi, Y., & Ochi, M. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0285 · Cited by 444
Zhang, Y., Zhu, W., He, H., Fan, B., Deng, R., Hong, Y., Liang, X., Zhao, H., Li, X., & Zhang, F. (2019) · Aging · doi:10.18632/aging.102592 · Cited by 93
Cited by
Cao, J.-Y., Wang, B., Tang, T.-T., Wen, Y., Li, Z.-L., Feng, S.-T., Wu, M., Liu, D., Yin, D., Ma, K.-L., et al. (2021) · Theranostics · doi:10.7150/thno.54550 · Cited by 303
Cheng, F., Yang, F., Wang, Y., Zhou, J., Qian, H., & Yan, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01942-y · Cited by 94
Li, Q., Fu, X., Kou, Y., & Han, N. (2023) · Theranostics · doi:10.7150/thno.84971 · Cited by 63
Noorzehi, G., Pasbakhsh, P., Taghizadeh, F., Alikarami, A., Kashani, I. R., & Mojaverrostami, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118027 · Cited by 3
Metadata
- Authors
- Wang, Z.-G., He, Z.-Y., Liang, S., Yang, Q., Cheng, P., & Chen, A.-M.
- Venue
- Stem Cell Research & Therapy
- Published
- 2020-11-27
- Volume
- 11
- Issue
- 1
- Pages
- 511-511
- ISSN
- 1757-6512 (ISSN-L)
- OpenAlex
- W3110076250
- Cited by
- 288
- References
- 4
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, Z.-G., He, Z.-Y., Liang, S., Yang, Q., Cheng, P., & Chen, A.-M. (2020). Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells. Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-020-02032-8
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