RETRACTED ARTICLE: Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4+ T cells
Open accessAbstract
Background: The immune system and the skeletal system have complex interactions in the bone marrow and even in the joints, which has promoted the development of the concept of osteoimmunology. Some evidence has indicated that T cells and B cells contribute to the balance between the resorption and formation of bone. However, there has been little discussion on the regulation of CD4+ T lymphocytes by cells involved in bone metabolism. Mesenchymal stem cells (MSCs), which exert core functions related to immunoregulation and osteogenic differentiation, are crucial cells linked to both bone metabolism and the immune system. Previous studies have shown that the immunoregulatory capacity of MSCs changes following differentiation. However, it is still unclear whether the osteogenic differentiation of MSCs affects the migration and differentiation of CD4+ T cells. Methods: MSCs were cultured in growth medium or osteogenic medium for 10 days and then cocultured with CD4+ T cells. CD4+ T cell migration and differentiation were detected by flow cytometry. Further, gene expression levels of specific cytokines were analyzed by quantitative real-time PCR and enzyme-linked immunosorbent assays. A Proteome Profiler Human XL Cytokine Array Kit was used to analyze supernatants collected from MSCs. Alizarin red S staining and Alkaline phosphatase assay were used to detect the osteogenic differentiation of MSCs. Results: Here, we found that the migration of CD4+ T cells was elevated, and the capacity to induce the differentiation of regulatory T (Treg) cells was weakened during MSC osteogenic differentiation, while the differentiation of T helper 1 (Th1), T helper 2 (Th2) and T helper 17 (Th17) cells was not affected. Further studies revealed that interleukin (IL)-8 was significantly upregulated during MSC osteogenic differentiation. Both a neutralizing antibody and IL-8-specific siRNA significantly inhibited the migration of CD4+ T cells and promoted the differentiation of Treg cells. Finally, we found that the transcription factor c-Jun was involved in regulating the expression of IL-8 and affected the osteogenic differentiation of MSCs, thereby mediating the migration and differentiation of CD4+ T cells. Conclusion: This study demonstrated that MSC osteogenic differentiation promoted c-Jun-dependent secretion of IL-8 and mediated the migration and differentiation of CD4+ T cells. These results provide a further understanding of the crosstalk between bone and the immune system and reveal information about the relationship between osteogenesis and inflammation in the field of osteoimmunology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-8 and MMP9 may affect the activity of cells critical to bone healing and may influence the bone healing process.
“IL-8 and MMP9 may affect the activity of these cells, which are critical participating cells in the bone healing process, in the manner described above and may, therefore, influence the bone healing process”
From Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature (2024) · cites this paper as [101]
The Discussion (page not provided) reports that IL-8 regulates CD4+ T-cell recruitment and polarization during mesenchymal stem-cell osteogenic differentiation, supporting the proposed effect on cells involved in bone biology. Our copy does not address MMP9 or show that either factor changes the bone-healing process itself. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · see citing works
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
Greenbaum, A. M., Hsu, Y.-M. S., Day, R. B., Schuettpelz, L. G., Christopher, M. J., Borgerding, J. N., Nagasawa, T., & Link, D. C. (2013) · Nature · doi:10.1038/nature11926 · Cited by 1,372 · see citing works
Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
Tsukasaki, M., & Takayanagi, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0178-8 · Cited by 790 · see citing works
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
Ha, H., Debnath, B., & Neamati, N. (2017) · Theranostics · doi:10.7150/thno.15625 · Cited by 788 · see citing works
Ghannam, S., Pène, J., Moquet-Torcy, G., Jørgensen, C., & Yssel, H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902007 · Cited by 597 · see citing works
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534 · see citing works
Luz‐Crawford, P., Kurte, M., Bravo-Alegria, J. B., Contreras-López, R. A., Nova‐Lamperti, E., Téjédor, G., Noël, D., Jørgensen, C., Figueroa, F. E., Djouad, F., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt216 · Cited by 489 · see citing works
IL-17-producing γδ T cells enhance bone regeneration
Ono, T., Okamoto, K., Nakashima, T., Nitta, T., Hori, S., Iwakura, Y., & Takayanagi, H. (2016) · Nature Communications · doi:10.1038/ncomms10928 · Cited by 371 · see citing works
c-Jun, at the crossroad of the signaling network
Meng, Q., & Xia, Y. (2011) · Protein & Cell · doi:10.1007/s13238-011-1113-3 · Cited by 298 · see citing works
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
Steffen, U., Lang, S. C., Pfeifle, R., Rombouts, Y., Frühbeißer, S., Amara, K., Bang, H., Lux, A., Koeleman, C. A. M., Baum, W., et al. (2015) · Nature Communications · doi:10.1038/ncomms7651 · Cited by 264 · see citing works
Court, A. C., Le‐Gatt, A., Luz‐Crawford, P., Parra, E., Aliaga‐Tobar, V., Bátiz, L. F., Contreras, R. A., Ortúzar, M. I., Kurte, M., Elizondo‐Vega, R., et al. (2020) · The EMBO Reports · doi:10.15252/embr.201948052 · Cited by 259 · see citing works
Interleukin-8 induces neutrophil transendothelial migration.
Smith, W., Gamble, J. R., Clark‐Lewis, I., & Vadas, M. A. (1991) · PubMed Central · Cited by 233 · see citing works
Proinflammatory T cells and IL-17 stimulate osteoblast differentiation
Croes, M., Öner, F. C., van Neerven, D., Sabir, E., Kruyt, M. C., Blokhuis, T. J., Dhert, W. J. A., & Alblas, J. (2016) · Bone · doi:10.1016/j.bone.2016.01.010 · Cited by 195 · see citing works
Liu, H., Li, R., Liu, T., Yang, L., Yin, G., & Xie, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01912 · Cited by 177 · see citing works
Activation of NF-κB and c-jun Transcription Factors in Multiple Sclerosis Lesions
Bonetti, B., Stegagno, C., Cannella, B., Rizzuto, N., Moretto, G., & Raine, C. S. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65456-9 · Cited by 163 · see citing works
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow
Yu, V. W. C., Sáez, B., Cook, C., Lotinun, S., Pardo–Saganta, A., Wang, Y., Lymperi, S., Ferraro, F., Raaijmakers, M. H. G. P., Wu, J. Y., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141843 · Cited by 163 · see citing works
Sun, D., JUNGER, W. G., Yuan, C., Zhang, W., Bao, Y., Qin, D., Wang, C., Tan, L., Qi, B., Zhu, D., et al. (2013) · Stem Cells · doi:10.1002/stem.1356 · Cited by 146 · see citing works
Bone marrow Th17 TNFα cells induce osteoclast differentiation, and link bone destruction to IBD
Ciucci, T., Ibáñez, L., Boucoiran, A., Birgy, É., Pène, J., Abou‐Ezzi, G., Arab, N., Rouleau, M., Hébuterne, X., Yssel, H., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-306947 · Cited by 145 · see citing works
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency
Terashima, A., Okamoto, K., Nakashima, T., Akira, S., Ikuta, K., & Takayanagi, H. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.012 · Cited by 143 · see citing works
The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer
Liu, Y., Chen, X., Cheng, R., Yang, F., Yu, M., Wang, C., Cui, S., Hong, Y., Liang, H., Liu, M., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-017-0751-3 · Cited by 130 · see citing works
Molloy, A. P., Martin, F. T., Dwyer, R. M., Griffin, T. P., Murphy, M. J., Barry, F., O’Brien, T., & Kerin, M. J. (2008) · International Journal of Cancer · doi:10.1002/ijc.23939 · Cited by 128 · see citing works
Hannemann, N., Jordan, J., Paul, S., Reid, S., Baenkler, H.-W., Sonnewald, S., Bäuerle, T., Vera, J., Schett, G. A., & Bözec, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601330 · Cited by 112 · see citing works
Xie, Z., Wang, P., Li, Y., Deng, W., Zhang, X., Su, H., Deng, L., Wu, Y., & Shen, H. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39433 · Cited by 108 · see citing works
Self-citationRozenberg, A., Rezk, A., Boivin, M., Darlington, P. J., Nyirenda, M., Li, R., Jalili, F., Winer, R., Artsy, E., Uccelli, A., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0243 · Cited by 88 · see citing works
Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone
Asano, T., Okamoto, K., Nakai, Y., Tsutsumi, M., Muro, R., Suematsu, A., Hashimoto, K., Okamura, T., Ehata, S., Nitta, T., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0104-1 · Cited by 85 · see citing works
Chen, X., McClurg, A. E., Zhou, G., McCaigue, M. D., Armstrong, M. A., & Li, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0268 · Cited by 84 · see citing works
Binding of CXCL8/IL‐8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
Krupa, A., Fol, M., Dziadek, B. R., Kępka, E., Wojciechowska, D., Brzostek, A. M., Torzewska, A., Dziadek, J., Baughman, R. P., Griffith, D. E., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/124762 · Cited by 80 · see citing works
Cen, S., Wang, P., Xie, Z., Yang, R., Li, J., Liu, Z., Wang, S., Wu, X., Liu, W., Li, M., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1380-0 · Cited by 70 · see citing works
Self-citationXu, L., Kelvin, D. J., Ye, G. Q., Taub, D. D., Ben‐Baruch, A., Oppenheim, J. J., & Wang, J. M. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.2.335 · Cited by 67 · see citing works
Self-citationEikawa, S., Ohue, Y., Kitaoka, K., Aji, T., Uenaka, A., Oka, M., & Nakayama, E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000225 · Cited by 65 · see citing works
Dooley, S., Herlitzka, I., Hanselmann, R. G., Ermis, A., Henn, W., REMBERGER, K., Hopf, T., & Welter, C. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.5.298 · Cited by 59 · see citing works
Yue, C., Guo, Z., Luo, Y., Yuan, J., Wan, X.-X., & Mo, Z. (2020) · Stem Cells International · doi:10.1155/2020/7430968 · Cited by 57 · see citing works
Crosstalk between c-Jun and TAp73α/β contributes to the apoptosis–survival balance
Koeppel, M., van Heeringen, S. J., Kramer, D., Smeenk, L., Janssen‐Megens, E. M., Hartmann, M., Stunnenberg, H. G., & Lohrum, M. A. E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr028 · Cited by 53 · see citing works
Xie, Z., Wang, P., Li, J., Li, Y., Wang, S., Wu, X., Sun, S., Cen, S., Su, H., Deng, W., et al. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1489-x · Cited by 52 · see citing works
Self-citationc-Jun transactivates Puma gene expression to promote osteoarthritis
Lu, H., HOU, G., ZHANG, Y., Dai, Y., & Zhao, H. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1981 · Cited by 51 · see citing works
Vasilev, G., Ivanova, M. G., Ivanova‐Todorova, E., Tumangelova-Yuzeir, K. D., Krasimirova, E., Stoilov, R. M., & Kyurkchiev, D. S. (2019) · Rheumatology International · doi:10.1007/s00296-019-04296-7 · Cited by 51 · see citing works
Transcription Factors in the Cellular Response to Charged Particle Exposure
Hellweg, C. E., Spitta, L. F., Henschenmacher, B., Diegeler, S., & Baumstark‐Khan, C. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00061 · Cited by 44 · see citing works
Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rheumatoid Arthritis
Feng, Z., Zhai, Y., Zheng, Z., Yang, L., Luo, X., Dong, X., Han, Q., Jin, J., Chen, Z., & Zhu, P. (2018) · Scientific Reports · doi:10.1038/s41598-017-18693-0 · Cited by 42 · see citing works
Geng, L., Tang, X., Wang, S., Sun, Y., Wang, D., Tsao, B. P., Feng, X., & Sun, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00233 · Cited by 40 · see citing works
Gu, H., Huang, Z., Yin, X., Zhang, J., Gong, L., Chen, J., Ke, R., Xu, J., Lü, L., & Cui, L. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.08.005 · Cited by 38 · see citing works
KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis
Wu, M.-C., Cheng, H.-H., Yeh, T., Li, Y.-C., Chen, T., Sit, W. Y., Chuu, C., Kung, H.-J., Chien, S., & Wang, W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1305-y · Cited by 35 · see citing works
Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus
Zhu, Y., & Feng, X. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0898-x · Cited by 32 · see citing works
Direct effects of interleukin-8 on growth and functional activity of T lymphocytes
Menyailo, M. E., Malashchenko, V. V., Шмаров, В. А., Газатова, Н. Д., Melashchenko, O. B., Гончаров, А. Г., Seledtsova, G. V., & Seledtsov, V. I. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.023 · Cited by 28 · see citing works
Lamas, J. R., Fernández‐Gutiérrez, B., Mucientes, A., Marco, F., Lópiz, Y., Jover, J. Á., Abásolo, L., & Rodríguez‐Rodríguez, L. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1894-y · Cited by 25 · see citing works
Umebashi, K., Tokito, A., Yamamoto, M., & Jougasaki, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191659 · Cited by 22 · see citing works
Zhang, Z., Ding, Y., Li, W., Song, B., & Yang, R. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4355 · Cited by 21 · see citing works
Self-citationLiu, X., Kumagai, G., Wada, K., Tanaka, T., Fujita, T., Sasaki, A., Furukawa, K., & Ishibashi, Y. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.07.013 · Cited by 20 · see citing works
Liu, Z., Wang, P., Cen, S., Gao, L., Xie, Z., Wu, X., Su, H., Wu, Y., & Shen, H. (2019) · Stem Cells International · doi:10.1155/2019/4143167 · Cited by 14 · see citing works
Self-citationKuca‐Warnawin, E., Plebańczyk, M., Bonek, K., & Kontny, E. (2021) · Stem Cells International · doi:10.1155/2021/6637328 · Cited by 11 · see citing works
JunB can enhance the transcription of IL‐8 in oral squamous cell carcinoma
Tsunoda, M., Fukasawa, M., Nishihara, A., Takada, L., & Asano, M. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29843 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [11]Smith WB Gamble JR Clark-Lewis I Vadas MA Interleukin-8 induces neutrophil transendothelial migration Immunology 1991 72 65 72 1997402 PMC1384337
Cited by
Sorted by citations
Zhao, S., Qiao, Z., Pfeifer, R., Pape, H.-C., Mao, K., Tang, H., Meng, B., Chen, S., & Liu, H. (2024) · European Journal of Medical Research · doi:10.1186/s40001-023-01604-7 · Cited by 35 · see citing works
Engineered Nano–Bio Interfaces for Stem Cell Therapy
Umer, A., Ghouri, M. D., Muyizere, T., Aqib, R. M., Muhaymin, A., Cai, R., & Chen, C. (2023) · Precision Chemistry · doi:10.1021/prechem.3c00056 · Cited by 30 · see citing works
Bousch, J. F., Beyersdorf, C., Schultz, K., Windolf, J., Suschek, C. V., & Maus, U. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212358 · Cited by 25 · see citing works
Fan, M., Tong, P., Li, Y., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · BMC Medicine · doi:10.1186/s12916-023-02923-6 · Cited by 22 · see citing works
Heikkinen, J., Tanner, T., Bergmann, U., Palosaari, S., & Lehenkari, P. P. (2024) · Tobacco Induced Diseases · doi:10.18332/tid/185281 · Cited by 15 · see citing works
Feng, Z., Yang, Y., Liu, X., Sun, H., Wen, B.-Y., Chen, Z., & Wei, B. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114017 · Cited by 11 · see citing works
Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma
Li, Z., Fu, R., Wen, X., & Zhang, L. (2023) · BMC Oral Health · doi:10.1186/s12903-022-02704-2 · Cited by 11 · see citing works
Khokhani, P., Belluomo, R., Croes, M., Gawlitta, D., Kruyt, M. C., & Weinans, H. (2022) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2022.0086 · Cited by 11 · see citing works
Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets
Ji, W., Sun, L. Y., Wang, D., & Zhu, W. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176996 · Cited by 9 · see citing works
ZFP36, an RNA-binding protein promotes hBMSCs osteogenic differentiation via binding with JUN
Su, H., Liang, L., Wang, J., Yuan, X., & Zhao, B. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05232-7 · Cited by 5 · see citing works
Wang, X., Guo, S., Zhou, H., Sun, Y., Gan, J., Zhang, Y., Zheng, W., Zhang, C., Zhao, X., Xiao, J., et al. (2023) · Cancers · doi:10.3390/cancers15020342 · Cited by 5 · see citing works
Pang, X., Chen, X., Jing, Y., Shi, F., Chen, X., Huang, H., & Liu, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1600713 · Cited by 4 · see citing works
Miłek, O., Tur, D., Ahčin, L., Voitseshyna, O., Behm, C., & Andrukhov, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216439 · Cited by 4 · see citing works
Liu, H., Wang, Z., Li, X., Zhao, B., Li, H., Han, L., & Yan, J. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04766-6 · Cited by 3 · see citing works
Shen, F., Xiao, H., & Shi, Q. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.08.005 · Cited by 3 · see citing works
The effects of SDF-1 combined application with VEGF on femoral distraction osteogenesis in rats
Fu, F., Li, M., Yang, S., Du, G., Xu, Y., Jiang, J., Jia, L., Zhang, K., & Li, P. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0851 · Cited by 3 · see citing works
Protocols for collecting mouse PDL cells and bone marrow cells, differentiation, and data analysis
Sirisereephap, K., Surboyo, M. D. C., Rosenkranz, A. L., Terao, Y., Tabeta, K., Maeda, T., Hajishengallis, G., & Maekawa, T. (2024) · STAR Protocols · doi:10.1016/j.xpro.2024.103162 · Cited by 2 · see citing works
Abo-Aziza, F. A. M., Albarrak, S. M., Zaki, A. K. A., & El-Shafey, S. (2022) · Veterinary World · doi:10.14202/vetworld.2022.2475-2490 · Cited by 1 · see citing works
Immunomodulatory Pathogen Recognition Receptor Ligands for Bone Regeneration
Khokhani, P. (2024) · doi:10.33540/2160 · Cited by 1 · see citing works
Buetti‐Dinh, A., Siverino, C., Garrido, J. U., Lanzillotti, C., Pianta, E., Grasso, G., Häckel, S., Stoddart, M. J., & Bella, E. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.12.705508 · Cited by 1 · see citing works
Wang, Y., Guo, J., Yang, F., Dong, R., Song, D., Huang, P., Wen, L., Xiang, G., Wang, S., Teng, J., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1118282
Osteogenic Differentiation in Chitosan-Based Scaffolds via P28 and VEGF Delivery
Zhou, K., Simonassi-Paiva, B., Pogue, R. E., Murphy, E., Cao, Z. Q., Fournet, M. B., & Devine, D. M. (2025) · Molecules · doi:10.3390/molecules30173645
Li, Z., Fu, R., Wen, X., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.22600690
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543233
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543242
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543236
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543257
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543251
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543254
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543245
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543248
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543239
Fan, M., Tong, P., Yan, L., Li, T., Ren, J., Huang, J., Du, W., Zhou, L., & Shan, L. (2023) · Figshare · doi:10.6084/m9.figshare.23543230
Song, N., Qiang, Z., Du, J., & Jiang, R. (2026) · Human Mutation · doi:10.1155/humu/9261651
- Authors
- Ye, F., Li, J., Xu, P., Xie, Z., Zheng, G., Liu, W., Ye, G., Yu, W., Lin, J., Su, Z., Che, Y., Zhang, Z., Wang, P., Wu, Y., & Shen, H.
- Affiliations
- Sun Yat-sen University (CN)
- Corresponding author
- Wang, Peng
- Wu, Yanfeng
- Shen, Huiyong
- ORCID
- Venue
- Stem Cell Research & Therapy
- Published
- 2022-02-05
- Volume
- 13
- Issue
- 1
- Pages
- 58-58
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC8818240
- OpenAlex
- W4210493837
- Cited by
- 35
- References
- 51
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 20 · 2022: 2
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2025-10-09)
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- national natural science foundation of china (81971518, 82002267)
- key-area research and development program of guangdong province (2019B020236001)
- technology project of shenzhen city (RCBS20200714114909007)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- mesenchymal stem cells, osteogenic differentiation, CD4+ T cells, interleukin-8, c-Jun, regulatory T cells, T cell migration, Th17 cells, Th1/Th2 cells, osteoimmunology, bone-immune crosstalk, immunomodulation, cytokine production, transcriptional regulation, retracted article
- MeSH terms
- Cell Differentiation, Cell Movement, Cells, Cultured, Humans, Osteogenesis, CD4-Positive T-Lymphocytes, Interleukin-8, Proto-Oncogene Proteins c-jun, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
