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Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair
Open accessAbstract
BACKGROUND: Biomaterials used in bone tissue engineering must fulfill the requirements of osteoconduction, osteoinduction, and osseointegration. However, biomaterials with good osteoconductive properties face several challenges, including inadequate vascularization, limited osteoinduction and barrier ability, as well as the potential to trigger immune and inflammatory responses. Therefore, there is an urgent need to develop guided bone regeneration membranes as a crucial component of tissue engineering strategies for repairing bone defects. METHODS: The mZIF-8/PLA membrane was prepared using electrospinning technology and simulated body fluid external mineralization method. Its ability to induce biomimetic mineralization was evaluated through TEM, EDS, XRD, FT-IR, zeta potential, and wettability techniques. The biocompatibility, osteoinduction properties, and osteo-immunomodulatory effects of the mZIF-8/PLA membrane were comprehensively evaluated by examining cell behaviors of surface-seeded BMSCs and macrophages, as well as the regulation of cellular genes and protein levels using PCR and WB. In vivo, the mZIF-8/PLA membrane's potential to promote bone regeneration and angiogenesis was assessed through Micro-CT and immunohistochemical staining. RESULTS: The mineralized deposition enhances hydrophilicity and cell compatibility of mZIF-8/PLA membrane. mZIF-8/PLA membrane promotes up-regulation of osteogenesis and angiogenesis related factors in BMSCs. Moreover, it induces the polarization of macrophages towards the M2 phenotype and modulates the local immune microenvironment. After 4-weeks of implantation, the mZIF-8/PLA membrane successfully bridges critical bone defects and almost completely repairs the defect area after 12-weeks, while significantly improving the strength and vascularization of new bone. CONCLUSIONS: The mZIF-8/PLA membrane with dual osteoconductive and immunomodulatory abilities could pave new research paths for bone tissue engineering.
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“In recent years, MOFs have provided an innovative platform for collaborative osteogenesis and immunomodulation, owing to their unique structural designability, high loading capacity, and controllable release properties [[38], [39], [40]].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [39]
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“Wang et al. suggest that the immunomodulatory mechanism of ZIF-8 may involve ions released during its biodegradation as well as its induced biomineralization processes [39].”
Self-citation
Metadata
- Authors
- Wang, B., Xie, X., Jiang, W., Zhan, Y., Zhang, Y., Guo, Y., Wang, Z., Guo, N., Guo, K., & Sun, J.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Wuhan Union Hospital (CN)
- Corresponding author
- Guo, Nengqiang
- Guo, Ke
- Sun, Jiaming
- Venue
- Stem Cell Research & Therapy
- Published
- 2024-05-07
- Volume
- 15
- Issue
- 1
- Pages
- 135-135
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC11077813
- OpenAlex
- W4396689525
- Cited by
- 27
- References
- 52
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 4
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Key R&D Program of China (2019YFA0110500)
- National Natural Science Foundation of China (82020108020, 82072198, 81873941, 81701922)
- Health Commission of Hubei Province scientific research project (WJ2021Z008)
- Jingshan Union Hospital program (2023-XHJS-004)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- metal-organic framework derived materials, polylactic acid, biomimetic mineralization, osteoinduction, osteoimmunomodulation, macrophage polarization, M2 macrophages, bone marrow mesenchymal stem cells, angiogenesis, bone defect repair, critical-size bone defect, bone tissue engineering
- MeSH terms
- Animals, Biocompatible Materials, Bone Regeneration, Membranes, Artificial, Osteogenesis, Polyesters, Tissue Engineering, Guided Tissue Regeneration, Mice, Rats, Tissue Scaffolds, Mesenchymal Stem Cells
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