The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics
Open accessAbstract
Metabolic syndrome (MS) comprises central obesity, increased plasma glucose levels, hyperlipidemia and hypertension, and its incidence is increasing due to changes in lifestyle and dietary structure in recent years. MS has been proven to be associated with an increased incidence of cardiovascular diseases and type 2 diabetes mellitus, leading to morbidity and mortality. In this manuscript, we review recent studies concerning the role of the gut microbiota in MS modulation. Manipulation of the gut microbiota through the administration of prebiotics or probiotics may assist in weight loss and reduce plasma glucose and serum lipid levels, decreasing the incidence of cardiovascular diseases and type 2 diabetes mellitus. To the best of our knowledge, short-chain fatty acids (SCFAs), bile salt hydrolase (BSH), metabolic endotoxemia and the endocannabinoid (eCB) system are essential in regulating the initiation and progression of MS through the normalization of adipogenesis and the regulation of insulin secretion, fat accumulation, energy homeostasis, and plasma cholesterol levels. Therefore, the gut microbiota may serve as a potential therapeutic target for MS. However, further studies are needed to enhance our understanding of manipulating the gut microbiota and the role of the gut microbiota in MS prevention and treatment.
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1 retracted
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Cited by
Probiotic species in the modulation of gut microbiota: An overview
Azad, M. A. K., Sarker, M., Li, T., & Yin, J. (2018) · BioMed Research International · doi:10.1155/2018/9478630 · Cited by 803
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585
Microbial impact on cholesterol and bile acid metabolism: current status and future prospects
Kriaa, A., Bourgin, M., Potiron, A., Mkaouar, H., Jablaoui, A., Gérard, P., Maguin, E., & Rhimi, M. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r088989 · Cited by 264
Probiotic Strain Lactobacillus casei BL23 Prevents Colitis‐Associated Colorectal Cancer
Jacouton, E., Chain, F., Sokol, H., Langella, P., & Bermúdez-Humarán, L. G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01553 · Cited by 249
One health, fermented foods and gut microbiota
Bell, V., Ferrão, J., Pimentel, L., Pintado, M., & Fernandes, T. (2018) · Foods · doi:10.3390/foods7120195 · Cited by 188
Metadata
- Authors
- He, M., & Shi, B.
- Venue
- Cell & Bioscience
- Published
- 2017-10-25
- Volume
- 7
- Issue
- 1
- Pages
- 54-54
- ISSN
- 2045-3701 (ISSN-L)
- OpenAlex
- W2765519733
- Cited by
- 336
- References
- 132
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- gold
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