Cited by 48Protease and Inhibitor MechanismsTissue Engineering and Regenerative MedicineTGF-β signaling in diseases

Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy

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Zhao, Peng, Sun, Tian, Lyu, Cheng, Liang, Kaini, Du, Yanan·2023·Cell Regeneration

Abstract

Investigation into the role of cells with respect to extracellular matrix (ECM) remodeling is still in its infancy. Particularly, ECM degradation is an indispensable process during the recovery from fibrosis. Cells with ECM degradation ability due to the secretion of various matrix metalloproteinases (MMPs) have emerged as novel contributors to the treatment of fibrotic diseases. In this review, we focus on the ECM degradation ability of cells associated with the repertoire of MMPs that facilitate the attenuation of fibrosis through the inhibition of ECM deposition. Besides, innovative approaches to engineering and characterizing cells with degradation ability, as well as elucidating the mechanism of the ECM degradation, are also illustrated. Studies conducted to date on the use of cell-based degradation for therapeutic purposes to combat fibrosis are summarized. Finally, we discuss the therapeutic potential of cells with high degradation ability, hoping to bridge the gap between benchside research and bedside applications in treating fibrotic diseases.

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Authors
Zhao, P., Sun, T., Lyu, C., Liang, K., & Du, Y.
Affiliations
Center for Life Sciences (CN)
Corresponding author
Du, Yanan
Venue
Cell Regeneration
Published
2023-09-01
Volume
12
Issue
1
Pages
29-29
ISSN
2045-9769 (ISSN-L)
OpenAlex
W4386314625
Cited by
48
References
126
Citations by year
2026: 15 · 2025: 24 · 2024: 9
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • Cell Regeneration (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Funders
National Natural Science Foundation of China (82125018)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
extracellular matrix degradation, extracellular matrix remodeling, fibrosis, antifibrotic therapy, matrix metalloproteinases, cell therapy, fibrotic diseases

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