Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy
Open accessAbstract
Investigation into the role of cells with respect to extracellular matrix (ECM) remodeling is still in its infancy. Particularly, ECM degradation is an indispensable process during the recovery from fibrosis. Cells with ECM degradation ability due to the secretion of various matrix metalloproteinases (MMPs) have emerged as novel contributors to the treatment of fibrotic diseases. In this review, we focus on the ECM degradation ability of cells associated with the repertoire of MMPs that facilitate the attenuation of fibrosis through the inhibition of ECM deposition. Besides, innovative approaches to engineering and characterizing cells with degradation ability, as well as elucidating the mechanism of the ECM degradation, are also illustrated. Studies conducted to date on the use of cell-based degradation for therapeutic purposes to combat fibrosis are summarized. Finally, we discuss the therapeutic potential of cells with high degradation ability, hoping to bridge the gap between benchside research and bedside applications in treating fibrotic diseases.
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Macrophages drive extracellular matrix deposition by fibroblasts during repair and can directly degrade and remodel the extracellular matrix during resolution.
“Many studies have also shown that macrophages drive ECM deposition by fibroblasts during the repair process and can directly degrade and remodel the ECM during resolution (11, 12).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [12]
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- Authors
- Zhao, P., Sun, T., Lyu, C., Liang, K., & Du, Y.
- Affiliations
- Center for Life Sciences (CN)
- Corresponding author
- Du, Yanan
- Venue
- Cell Regeneration
- Published
- 2023-09-01
- Volume
- 12
- Issue
- 1
- Pages
- 29-29
- ISSN
- 2045-9769 (ISSN-L)
- PMC
- PMC10471565
- OpenAlex
- W4386314625
- Cited by
- 48
- References
- 126
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 9
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Cell Regeneration (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- National Natural Science Foundation of China (82125018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- extracellular matrix degradation, extracellular matrix remodeling, fibrosis, antifibrotic therapy, matrix metalloproteinases, cell therapy, fibrotic diseases
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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