Prevalence and prognosis of acutely ill patients with organ failure at arrival to hospital: Protocol for a systematic review
Open accessAbstract
BACKGROUND: Acutely ill patients are a heterogeneous group, and some of these suffer from organ failure. As the prognosis of organ failure improves with early treatment, it is important to identify these patients as early as possible. Most studies on organ failure have been performed in intensive care settings, or on selected groups of patients, where a high prevalence and mortality have been reported. Before patients arrive to the intensive care unit, or the general ward, most of them have passed through the emergency department (ED), where diagnosis and treatment has been initiated. The prevalence and prognosis of acutely ill patients, with organ failure, at arrival have been studied in some selected groups, but methods and results differ. This systematic review aims to identify, summarize, and analyze studies of prevalence and prognosis of new onset organ failure in acutely ill undifferentiated patients, at arrival to hospital. The result of the review will assist physicians working in an ED, when assessing patients' risk of organ failure and their associated prognosis. METHODS: The information sources used are electronic databases, PubMed, Cochrane Library, EMBASE, and CINAHL; references in included studies and review articles; and authors' personal files. One author will perform the title and abstract screening and exclude obviously ineligible studies. By an independent full-text screening, two authors will decide on the eligibility for the remaining studies. Eligible studies will include an unselected group of acutely ill adult patients at arrival to hospital, with one or more organ failures (respiratory, renal, cerebral, circulatory, hepatic, or coagulation failure). Included studies will have assessed the prevalence or prognosis, defined as mortality or ICU transfer, of new onset organ failure. From included studies, bibliographical and study description data, patient characteristics, and data related to prevalence of organ failure and prognosis will be extracted. We will assess risk of bias in included studies using the Quality in Prognosis Studies tool for prognostic studies and the Newcastle-Ottawa Scale for observational studies. We expect heterogeneity and to conduct a qualitative synthesis of the results. If, however, heterogeneity is low, we will conduct a random effects meta-analysis stratified by basic study design. DISCUSSION: This review will summarize and analyze studies of prevalence and prognosis of acutely ill patients, with organ failure at arrival to hospital, assist ED physicians assessing the risk of organ failure in unselected patients, and guide recommendations for further research. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017060871.
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Critically ill patients have a high prevalence of at least one organ failure (51%-72%) at some point during ICU stay, with respiratory failure being the most prevalent (87% of patients with organ failure).
“Such patients have a high prevalence of at least one organ failure (51%–72%) at some point during their stay in ICU, with respiratory failure being the most prevalent (constituting 87% of patients with organ failure) (Pedersen et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Pedersen et al., 2017
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PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,577 · see citing works
(2014) · Medical Entomology and Zoology · Cited by 17,633 · see citing works
Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & the PRISMA-P Group (2015) · BMJ · doi:10.1136/bmj.g7647 · Cited by 13,120 · see citing works
GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables
Guyatt, G., Oxman, A. D., Akl, E. A., Kunz, R., Vist, G., Brozek, J., Norris, S., Falck-Ytter, Y., Glasziou, P., & deBeer, H. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.04.026 · Cited by 10,681 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544 · see citing works
Severe Sepsis and Septic Shock
Angus, D. C., & van der Poll, T. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1208623 · Cited by 3,993 · see citing works
(2008) · Cited by 3,790 · see citing works
Assessing Bias in Studies of Prognostic Factors
Hayden, J. A., van der Windt, D. A., Cartwright, J. L., Côté, P., & Bombardier, C. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-4-201302190-00009 · Cited by 3,287 · see citing works
Churpek, M. M., Zadravecz, F. J., Winslow, C. J., Howell, M. D., & Edelson, D. P. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201502-0275oc · Cited by 361 · see citing works
Shapiro, N. I., Howell, M. D., Bates, D. W., Angus, D. C., Ngo, L. H., & Talmor, D. S. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.07.007 · Cited by 203 · see citing works
Sakr, Y. L., Lobo, S. M., Moreno, R. P., Gerlach, H., Ranieri, V. M., Michalopoulos, A. S., Vincent, J., & the SOAP Investigators (2012) · Critical Care · doi:10.1186/cc11868 · Cited by 149 · see citing works
Severe Sepsis and Septic Shock
Calis, J. C. J., van Woensel, J., & Lemson, J. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1312359 · Cited by 143 · see citing works
Rohde, J. M., Odden, A., Bonham, C. A., Kuhn, L. E., Malani, P., Chen, L. M., Flanders, S. A., & Iwashyna, T. J. (2013) · Journal of Hospital Medicine · doi:10.1002/jhm.2012 · Cited by 82 · see citing works
Lone, N., & Walsh, T. S. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0059oc · Cited by 70 · see citing works
The long-term burden of severe sepsis and septic shock
Guirgis, F. W., Brakenridge, S. C., Sutchu, S., Khadpe, J. D., Robinson, T. J., Westenbarger, R., Topp, S. T., Kalynych, C. J., Reynolds, J. A., Dodani, S., et al. (2016) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001135 · Cited by 61 · see citing works
Bingold, T. M., Lefering, R. L., Zacharowski, K. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134329 · Cited by 49 · see citing works
Chen, Y., & Li, C. (2014) · Critical Care · doi:10.1186/cc13832 · Cited by 41 · see citing works
Ranzani, O., Zampieri, F. G., Besen, B. A. M. P., Azevedo, L. C. P., & Park, M. (2015) · Critical Care · doi:10.1186/s13054-015-0986-6 · Cited by 33 · see citing works
Shock in the emergency department; a 12 year population based cohort study
Holler, J. G., Henriksen, D. P., Mikkelsen, S. S., et al. (2016) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-016-0280-x · Cited by 29 · see citing works
Self-citationBenns, M. V., Carr, B. G., Kallan, M. J., & Sims, C. A. (2013) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e31829cfa19 · Cited by 26 · see citing works
Shock in the emergency department
Wilson, R. F., Wilson, J. A., GIBSON, D. B., et al. (1976) · Journal of the American College of Emergency Physicians · doi:10.1016/s0361-1124(76)80100-1 · Cited by 17 · see citing works
Kakebeeke, D., Vis, A., de Deckere, E. R. J. T., Sandel, M. H., & de Groot, B. (2013) · International Journal of Emergency Medicine · doi:10.1186/1865-1380-6-4 · Cited by 17 · see citing works
Holler, J. G., Henriksen, D. P., Mikkelsen, S. S., et al. (2016) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-016-0209-4 · Cited by 10 · see citing works
Self-citationJessen, M. K., Skibsted, S., & Shapiro, N. I. (2015) · European Journal of Emergency Medicine · doi:10.1097/mej.0000000000000317 · Cited by 8 · see citing works
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Research works printed but not linked: 2
- [21]Ryan R Cochrane Consumers and Communication Review Group Heterogeneity and subgroup analysis in Cochrane consumers and communication group reviews: planning the analysis at protocol stage 2016
- [22]Ryan R Cochrane Consumers and Communication Review Group Cochrane consumers and communication review group: data synthesis and analysis 2016
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Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
- Authors
- Pedersen, P. B., Hrobjartsson, A., Nielsen, D. L., Henriksen, D. P., Brabrand, M., & Lassen, A. T.
- Affiliations
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Corresponding author
- Pedersen, Peter Bank
- Venue
- Systematic Reviews
- Published
- 2017-11-15
- Volume
- 6
- Issue
- 1
- Pages
- 227-227
- ISSN
- 2046-4053 (ISSN-L)
- PMC
- PMC5688673
- OpenAlex
- W2769167068
- Cited by
- 6
- References
- 25
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1
- FWCI
- 0.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Systematic Reviews (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Syddansk Universitet
- TrygFonden
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Emergency Medicine › Emergency and Acute Care Studies
- Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
- Keywords
- organ failure, acute illness, emergency department, hospitalization, prevalence, prognosis, mortality, ICU transfer, respiratory failure, renal failure, liver failure, coagulopathy, circulatory failure
- MeSH terms
- Systematic Reviews as Topic, Critical Care, Emergency Service, Hospital, Hospitals, Humans, Intensive Care Units, Length of Stay, Patient Transfer, Prognosis, Research Design, Prevalence, Critical Illness
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