The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Let‐7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Open accessAbstract
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let‐7 (MIRLET7) family controls developmental timing and differentiation. Let‐7 loss contributes to carcinogenesis via an increase in its target oncogenes and stemness factors. Let‐7 targets include genes regulating the cell cycle, cell signaling, and maintenance of differentiation. It is categorized as a tumor suppressor because it reduces cancer aggressiveness, chemoresistance, and radioresistance. However, in rare situations let‐7 acts as an oncogene, increasing cancer migration, invasion, chemoresistance, and expression of genes associated with progression and metastasis. Here, we review let‐7 function as tumor suppressor and oncogene, considering let‐7 as a potential diagnostic and prognostic marker, and a therapeutic target for cancer treatment. We explain the complex regulation and function of different let‐7 family members, pointing to abnormal processes involved in carcinogenesis. Let‐7 is a promising option to complement conventional cancer therapy, but requires a tumor specific delivery method to avoid toxicity. While let‐7 therapy is not yet established, we make the case that assessing its tumor presence is crucial when choosing therapy. Clinical data demonstrate that let‐7 can be used as a biomarker for rational precision medicine decisions, resulting in improved patient survival.
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Cites
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MicroRNA as an Important Target for Anticancer Drug Development
Fu, Z., Wang, L., Li, S., Chen, F., Au-Yeung, K. K.-W., & Shi, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.736323 · Cited by 133
Bernstein, D. L., Jiang, X., & Rom, S. (2021) · Biomedicines · doi:10.3390/biomedicines9060606 · Cited by 88
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Metadata
- Authors
- Chirshev, E., Oberg, K. C., Ioffe, Y. J., & Unternaehrer, J. J.
- Venue
- Clinical and Translational Medicine
- Publisher
- Wiley
- Published
- 2019-08-28
- Volume
- 8
- Issue
- 1
- Pages
- 24-24
- ISSN
- 2001-1326 (ISSN-L)
- OpenAlex
- W2970033143
- Cited by
- 253
- References
- 149
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chirshev, E., Oberg, K. C., Ioffe, Y. J., & Unternaehrer, J. J. (2019). Let‐7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer. Clinical and Translational Medicine. https://doi.org/10.1186/s40169-019-0240-y
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