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Cited by 57Genetics and Physical PerformanceSports Performance and TrainingCardiovascular Effects of Exercise

ACTN3 R577X polymorphism is not associated with team sport athletic status in Italians

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Massidda, Myosotis, Bachis, Valeria, Corrias, Laura, Piras, Francesco, Scorcu, Marco, Culigioni, Claudia, Masala, Daniele, Calò, Carla M·2015·Sports Medicine - Open
DOI 10.1186/s40798-015-0008-xPMC PMC4532716
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Abstract

BACKGROUND: The ACTN3 gene may influence performance in team sports, in which sprint action and high-speed movements, regulated by the anaerobic energy system, are crucial to the ultimate success of a match. The aim of this study was to determine the association between the ACTN3 R577X (rs1815739) polymorphism and elite team sport athletic status in Italian male athletes. METHODS: We compared the genotype and allele frequency of the ACTN3 R577X polymorphism between team sport athletes (n = 75), endurance athletes (n = 40), sprint/power athletes (n = 64), and non-athletic healthy controls (n = 192) from Italy. Genomic DNA was collected using a buccal swab. Extraction was performed according to the manufacturer's directions provided with a commercially available kit (Qiagen S.r.l., Milan, Italy). RESULTS: Team sport athletes showed a lower frequency of the 577RR genotype compared to the 577XX genotype than sprint/power athletes (p = 0.044). However, the ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls. CONCLUSIONS: Our results agree with a recent large-scale study involving athletes from Spain, Poland, and Russia. The ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.

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  • ACTN3 genotype was not different between endurance and elite team sport athletes.

    “who also showed ACTN3 genotype was not different between endurance and elite team sport athletes”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Massidda et al., 2015

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Cited by

Sorted by citations

Authors
Massidda, M., Bachis, V., Corrias, L., Piras, F., Scorcu, M., Culigioni, C., Masala, D., & Calò, C. M.
Affiliations
  • University of Cagliari (IT)
  • Università degli studi di Cassino e del Lazio Meridionale (IT)
Corresponding author
Massidda, Myosotis
ORCID
Venue
Sports Medicine - Open
Publisher
Springer Science and Business Media LLC
Published
2015-03-27
Volume
1
Issue
1
Pages
6-6
ISSN
  • 2198-9761 (ISSN-L)
  • 2199-1170
DOI
10.1186/s40798-015-0008-x
PMC
PMC4532716
OpenAlex
W1967234246
Cited by
57
References
0
Citations by year
2026: 1 · 2025: 9 · 2024: 18 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 1 · 2016: 1
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Sports Medicine - Open (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi di Cassino (submittedVersion, other-oa)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
ACTN3, R577X polymorphism, alpha-actinin-3, team sport athletes, genotype frequency, endurance athletes, anaerobic energy system

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