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Cited by 803D Printing in Biomedical ResearchHydrogels: synthesis, properties, applicationsSilk-based biomaterials and applications

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Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering

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Choi, Geunho, Cha, Hyung Joon·2019·Biomaterials Research
DOI 10.1186/s40824-019-0168-8PMC PMC6862824
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Abstract

Background: In recent years, three-dimensional (3D) printing has begun to be widely used in tissue engineering. Natural biomaterials have been employed to overcome the limitations of synthetic polymers. However, their low mechanical strength and poor printability are major disadvantages. Photocrosslinking is the most promising fabrication strategy because it is non-invasive and easy to control light intensity and exposure. In this article, developments of photocrosslinkable natural biomaterials in the field of 3D printing are reviewed. Main body: Photocrosslinkable biomaterials can be broadly classified into materials that use ultraviolet (UV) and visible lights. Many natural biomaterials such as gelatin, hydroxyapatite, silk fibroin, and pectin have been modified through acrylation, crosslinked by 365 nm UV light, and 3D printed. Riboflavin could also be used to crosslink and print collagen or decellularized extracellular matrix (dECM). In the case of silk-like aneroin and modified gelatin, crosslinking is possible by forming a dityrosine bond using 452 nm visible light. Conclusion: Despite the tremendous researches on the developments of photocrosslinkable 3D printing natural biomaterials, further efforts are necessary to develop source biomaterials with excellent biological functions and sufficient mechanical integrity.

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Metadata

Authors
Choi, G., & Cha, H. J.
Affiliations
  • Pohang University of Science and Technology (KR)
  • Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, South Korea.
ORCID
Venue
Biomaterials Research
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-11-19
Volume
23
Issue
1
Pages
18-18
ISSN
  • 1226-4601 (ISSN-L)
  • 2055-7124
DOI
10.1186/s40824-019-0168-8
PMC
PMC6862824
OpenAlex
W2989813791
Cited by
80
References
1
Citations by year
2026: 13 · 2025: 5 · 2024: 13 · 2023: 20 · 2022: 11 · 2021: 10 · 2020: 7
FWCI
0.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomaterials Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministry of Oceans and Fisheries, Korea (-)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
3D bioprinting, natural biomaterials, tissue engineering, gelatin, hydroxyapatite, silk fibroin, pectin, acrylation, UV crosslinking, visible light crosslinking, riboflavin, collagen, decellularized extracellular matrix, printability, mechanical strength

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