The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Oxidative stress in chronic kidney disease
Open accessAbstract
For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovascular disease. One of the main novel risk factors is oxidative stress, which occurs when there is overproduction of reactive oxygen species (ROS) and/or a reduction in antioxidant defense capacity. Oxidative stress is involved in the progression of renal injury, pathogenesis of atherosclerosis, and exacerbation of disease burden in CKD patients. In addition, uremic- and dialysis-associated factors in these patients further contribute to oxidative stress via a proinflammatory state, including exposure to dialysate endotoxins or the use of bioincompatible hemodialysis dialyzer membranes. Consequences of oxidative stress in CKD patients include atherosclerosis, amyloidosis, and anemia. Strategies to combat oxidative stress include antioxidant therapies such as vitamins C and E or N -acetylcysteine (NAC). While these antioxidant strategies are promising, few interventional studies have examined their effects until now. In light of the disparate experimental and clinical data, large, randomized, long-term studies are required to establish their efficacy and safety in CKD patients.
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“Oxidative stress in chronic kidney diseases is characterized by several distinct pathways: oxidative stress mediated by ROS (·OH), nitrosative stress mediated by RNS (ONOO−, ·NO2), chlorinated stress mediated by chlorinated species (HOCl), and carbonyl stress (Advanced glycation end products, AGEs) (Ling and Kuo 2018).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ling and Kuo 2018
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Cited by
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases
Kowalczyk, P., Sulejczak, D., Kleczkowska, P., Bukowska‐Ośko, I., Kucia, M., Popiel, M., Wietrak, E., Kramkowski, K., Wrzosek, K., & Kaczyńska, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413384 · Cited by 551
Leyane, T. S., Jere, S. W., & Houreld, N. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137273 · Cited by 536
Tirichen, H., Yaigoub, H., Xu, W., Wu, C., Li, R., & Li, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.627837 · Cited by 450
Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease
Podkowińska, A., & Formanowicz, D. (2020) · Antioxidants · doi:10.3390/antiox9080752 · Cited by 378
Metadata
- Authors
- Ling, X. C., & Kuo, K.-L.
- Affiliations
- Taipei Medical University (TW)
- Tzu Chi University (TW)
- Corresponding author
- Kuo, Ko-Lin
- Venue
- Renal Replacement Therapy
- Published
- 2018-12
- Volume
- 4
- Issue
- 1
- ISSN
- 2059-1381 (ISSN-L)
- OpenAlex
- W2271595134
- Cited by
- 183
- References
- 133
- Citations by year
- 2026: 21 · 2025: 33 · 2024: 20 · 2023: 25 · 2022: 26 · 2021: 30 · 2020: 15 · 2019: 7 · 2018: 1
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Renal Replacement Therapy (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Science and Technology, R.O.C. (MOST 105-2314-B-303-013-MY3)
- Taipei Tzu Chi Hospital (TCRD-TPE-107-24)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- oxidative stress, chronic kidney disease, reactive oxygen species, antioxidant defense, cardiovascular risk, atherosclerosis, uremic toxins, endotoxin, amyloidosis, anemia, antioxidant therapy, N-acetylcysteine, vitamins C and E
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