Cited by 183Antioxidant Activity and Oxidative StressDialysis and Renal Disease ManagementChronic Kidney Disease and Diabetes

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Oxidative stress in chronic kidney disease

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Ling, Xiao Chun, Kuo, Ko-Lin·2018·Renal Replacement Therapy

DOI 10.1186/s41100-018-0195-2

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Abstract

For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovascular disease. One of the main novel risk factors is oxidative stress, which occurs when there is overproduction of reactive oxygen species (ROS) and/or a reduction in antioxidant defense capacity. Oxidative stress is involved in the progression of renal injury, pathogenesis of atherosclerosis, and exacerbation of disease burden in CKD patients. In addition, uremic- and dialysis-associated factors in these patients further contribute to oxidative stress via a proinflammatory state, including exposure to dialysate endotoxins or the use of bioincompatible hemodialysis dialyzer membranes. Consequences of oxidative stress in CKD patients include atherosclerosis, amyloidosis, and anemia. Strategies to combat oxidative stress include antioxidant therapies such as vitamins C and E or N -acetylcysteine (NAC). While these antioxidant strategies are promising, few interventional studies have examined their effects until now. In light of the disparate experimental and clinical data, large, randomized, long-term studies are required to establish their efficacy and safety in CKD patients.

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Authors: Ling, X. C., & Kuo, K.-L.
Affiliations: Taipei Medical University (TW)
Tzu Chi University (TW)
Corresponding author: Kuo, Ko-Lin
ORCID: Ling, Xiao Chun
Kuo, Ko-Lin
Venue: Renal Replacement Therapy
Publisher: Springer Science and Business Media LLC
Published: 2018-12
Volume: 4
Issue: 1
ISSN: 2059-1381 (ISSN-L)
DOI: 10.1186/s41100-018-0195-2
OpenAlex: W2271595134
Cited by: 183
References: 133
Citations by year: 2026: 21 · 2025: 33 · 2024: 20 · 2023: 25 · 2022: 26 · 2021: 30 · 2020: 15 · 2019: 7 · 2018: 1
FWCI: 9.08
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: Renal Replacement Therapy (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ministry of Science and Technology, R.O.C. (MOST 105-2314-B-303-013-MY3)
Taipei Tzu Chi Hospital (TCRD-TPE-107-24)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: oxidative stress, chronic kidney disease, reactive oxygen species, antioxidant defense, cardiovascular risk, atherosclerosis, uremic toxins, endotoxin, amyloidosis, anemia, antioxidant therapy, N-acetylcysteine, vitamins C and E

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