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Cited by 165Immunotherapy and Immune ResponsesNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune Response and Inflammation

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes

Megiovanni, Anna Maria, Sanchez, Françoise, Robledo-Sarmiento, Macarena, Morel, Céline, Gluckman, Jean Claude, Boudaly, Sarah·2006·Journal of Leukocyte Biology
DOI 10.1189/jlb.0905526
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Abstract

Polymorphonuclear neutrophils (PMNs) are rapidly recruited to tissues upon injury or infection. There, they can encounter local and/or recruited immature dendritic cells (iDCs), a colocalization that could promote at least transient interactions and mutually influence the two leukocyte populations. Using human live blood PMNs and monocyte-derived iDCs, we examined if these leukocytes actually interacted and whether this influenced DC function. Indeed, coculture with live but not apoptotic PMNs led to up-regulation of membrane CD40, CD86, and human leukocyte antigen (HLA)-DR on DCs. Whereas CD40 up-regulation was dependent on soluble factors released by PMNs, as determined in cultures conducted in different chambers, cell contact was necessary for CD86 and HLA-DR up-regulation, a process that was inhibited by anti-CD18 antibodies, indicating that CD18 ligation was required. We also found that via a cell contact-dependent mechanism, DCs acquired Candida albicans-derived antigens from live as well as from apoptotic PMNs and could thus elicit antigen-specific T lymphocyte responses. Altogether, our data demonstrate the occurrence of cross-talk between human PMNs and DCs and provide new insights into the immune processes occurring upstream of the interactions between DCs and T lymphocytes.

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Crossref · 10.1189/jlb.0905526

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Metadata

Authors
Megiovanni, A. M., Sanchez, F., Robledo-Sarmiento, M., Morel, C., Gluckman, J. C., & Boudaly, S.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Boudaly, Sarah
Venue
Journal of Leukocyte Biology
Publisher
Oxford University Press (OUP)
Published
2006-02-24
Volume
79
Issue
5
Pages
977-988
ISSN
  • 0741-5400 (ISSN-L)
  • 1938-3673
DOI
10.1189/jlb.0905526
OpenAlex
W2149072530
Cited by
165
References
65
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 15 · 2012: 13
FWCI
4.16
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • Journal of Leukocyte Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agence Nationale de Recherche sur le SIDA
  • Association pour la Recherche sur le Cancer
  • Comité de Paris de la Ligue Nationale Contre le Cancer
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
neutrophils, dendritic cells, dendritic cell activation, CD86, HLA-DR, antigen uptake, Candida albicans, T cell activation, soluble factors, monocyte-derived dendritic cells
MeSH terms
Antigens, Surface, Candida albicans, Candidiasis, Cell Communication, Cells, Cultured, Dendritic Cells, HLA-DR Antigens, Humans, Immunity, Cellular, Ligation, Lymphocyte Activation, Neutrophils, Phagocytosis, T-Lymphocytes, Signal Transduction, Up-Regulation, Immunophenotyping, Antigen Presentation, CD18 Antigens, Coculture Techniques, CD40 Antigens, B7-2 Antigen

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