The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes
Abstract
Polymorphonuclear neutrophils (PMNs) are rapidly recruited to tissues upon injury or infection. There, they can encounter local and/or recruited immature dendritic cells (iDCs), a colocalization that could promote at least transient interactions and mutually influence the two leukocyte populations. Using human live blood PMNs and monocyte-derived iDCs, we examined if these leukocytes actually interacted and whether this influenced DC function. Indeed, coculture with live but not apoptotic PMNs led to up-regulation of membrane CD40, CD86, and human leukocyte antigen (HLA)-DR on DCs. Whereas CD40 up-regulation was dependent on soluble factors released by PMNs, as determined in cultures conducted in different chambers, cell contact was necessary for CD86 and HLA-DR up-regulation, a process that was inhibited by anti-CD18 antibodies, indicating that CD18 ligation was required. We also found that via a cell contact-dependent mechanism, DCs acquired Candida albicans-derived antigens from live as well as from apoptotic PMNs and could thus elicit antigen-specific T lymphocyte responses. Altogether, our data demonstrate the occurrence of cross-talk between human PMNs and DCs and provide new insights into the immune processes occurring upstream of the interactions between DCs and T lymphocytes.
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“Neutrophils are the transport vehicle for intracellular pathogens carrying antigens to DCs and participate in the activation of the T-cell immune response by DCs [222].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [222]
Citations
Cites
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Neutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,159
Diverse novel functions of neutrophils in immunity, inflammation, and beyond
Mócsai, A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122220 · Cited by 706
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
Mathias, J. R., Perrin, B. J., Liu, T.-X., Kanki, J. P., Look, A. T., & Huttenlocher, A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0506346 · Cited by 542
Neutrophils: Cinderella of innate immune system
Kumar, V., & Sharma, A. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.012 · Cited by 455
Tumor associated macrophages and neutrophils in tumor progression
Galdiero, M. R., Garlanda, C., Jaillon, S., Marone, G., & Mantovani, A. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24260 · Cited by 457
Metadata
- Authors
- Megiovanni, A. M., Sanchez, F., Robledo-Sarmiento, M., Morel, C., Gluckman, J. C., & Boudaly, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Boudaly, Sarah
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02-24
- Volume
- 79
- Issue
- 5
- Pages
- 977-988
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2149072530
- Cited by
- 165
- References
- 65
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 15 · 2012: 13
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de Recherche sur le SIDA
- Association pour la Recherche sur le Cancer
- Comité de Paris de la Ligue Nationale Contre le Cancer
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- neutrophils, dendritic cells, dendritic cell activation, CD86, HLA-DR, antigen uptake, Candida albicans, T cell activation, soluble factors, monocyte-derived dendritic cells
- MeSH terms
- Antigens, Surface, Candida albicans, Candidiasis, Cell Communication, Cells, Cultured, Dendritic Cells, HLA-DR Antigens, Humans, Immunity, Cellular, Ligation, Lymphocyte Activation, Neutrophils, Phagocytosis, T-Lymphocytes, Signal Transduction, Up-Regulation, Immunophenotyping, Antigen Presentation, CD18 Antigens, Coculture Techniques, CD40 Antigens, B7-2 Antigen
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