CoChat
Sign Up
Cited by 467Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.

ROS production in phagocytes: why, when, and where?

Dupré-Crochet, Sophie, Erard, Marie, Nüβe, Oliver·2013·Journal of Leukocyte Biology
DOI 10.1189/jlb.1012544
Open this paper in CoChat — free account

Abstract

In the phagocytosis field, ROS production by the phagocyte NOX has been associated with pathogen killing for the last 50 years. Since the discovery of nonphagocyte NOX, numerous other roles for ROS production have been identified. Oxidative stress and ROS-mediated signaling have received much attention in recent years. Much lower concentrations of ROS may be required for signaling compared with microbial killing. Based on the discoveries in nonphagocytic cells, it became logical to look for ROS functions distinct from pathogen killing, even in phagocytes. ROS are now linked to various forms of cell death, to chemotaxis, and to numerous modifications of cellular processes, including the NOX itself. ROS functions are clearly concentration-dependent over a wide range of concentrations. How much is required for which function? Which species are required for how much time? Is ROS signaling only a side effect of bactericidal ROS production? One major obstacle to answer these questions is the difficulty of reliable quantitative ROS detection. Signal transduction often takes place on a subcellular scale over periods of seconds or minutes, so the detection methods need to provide appropriate time and space resolution. We present examples of local ROS production, decreased degradation, signaling events, and potentially ROS-sensitive functions. We attempt to illustrate the current limitations for quantitative spatiotemporal ROS detection and point out directions for ongoing development. Probes for localized ROS detection and for combined detection of ROS, together with protein localization or other cellular parameters, are constantly improved.

Overview

Integrity signals

Registry

Crossref · 10.1189/jlb.1012544

Cites

166 of 166 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

1 retracted

Flagged first, then by citations

Show all 166 references

Research works printed but not linked: 2

  1. Figueira, 2013, Antioxid. Redox Signal.
  2. Amatore, 2000, Faraday Discuss.

Cited by

Sorted by citations

Items 401–467 of 467

Related

See all

Metadata

Authors
Dupré-Crochet, S., Erard, M., & Nüβe, O.
Affiliations
  • University Paris-Sud , Orsay, France
  • Université Paris-Sud (FR)
Corresponding author
Nüβe, Oliver
ORCID
Erard, Marie
Venue
Journal of Leukocyte Biology
Publisher
Oxford University Press (OUP)
Published
2013-10-01
Volume
94
Issue
4
Pages
657-670
ISSN
  • 0741-5400 (ISSN-L)
  • 1938-3673
DOI
10.1189/jlb.1012544
OpenAlex
W2131917465
Cited by
467
References
166
Citations by year
2026: 26 · 2025: 35 · 2024: 34 · 2023: 35 · 2022: 54 · 2021: 58 · 2020: 47 · 2019: 40 · 2018: 37 · 2017: 32 · 2016: 35 · 2015: 17 · 2014: 16 · 2013: 1
FWCI
2.01
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • Journal of Leukocyte Biology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Institut National de la Santé et de la Recherche Médicale
  • Centre National de la Recherche Scientifique
  • University Paris-Sud (GDR2588)
  • French Ministry of Research
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
reactive oxygen species, phagocytes, NADPH oxidase, phagocytosis, oxidative stress, ROS signaling, cell death, chemotaxis, pathogen killing
MeSH terms
Animals, Humans, Phagocytes, Phagocytosis, Signal Transduction, Cell Death, Reactive Oxygen Species, Models, Immunological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review