The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Interferon-λs: the modulators of antivirus, antitumor, and immune responses
Abstract
Recent findings concerning the biology of IFN-λs and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms are summarized. IFN-λs, including IFN-λ1, IFN-λ2, and IFN-λ3, also known as IL-29, IL-28A, or IL-28B, are a newly described group of cytokines distantly related to the type I IFNs and IL-10 family members. The IFN-λR complex consists of a unique ligand-binding chain, IFN-λR1 (also designated IL-28Rα), and an accessory chain, IL-10R2, which is shared with receptors for IL-10-related cytokines. IFN-λs signal through the IFN-λR and activate pathways of JAK-STATs and MAPKs to induce antiviral, antiproliferative, antitumor, and immune responses. In this review, we summarize recent findings about the biology of IFN-λs and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms.
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Cites
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
Role of deficient type III interferon-λ production in asthma exacerbations
Contoli, M., Message, S. D., Laza-Stanca, V., Edwards, M. R., Wark, P. A. B., Bartlett, N. W., Kebadze, T., Mallia, P., Stanciu, L. A., Parker, H. L., et al. (2006) · Nature Medicine · doi:10.1038/nm1462 · Cited by 1,006
DUMOUTIER, L., LEJEUNE, D., HOR, S., FICKENSCHER, H., & RENAULD, J.-C. (2003) · Biochemical Journal · doi:10.1042/bj20021935 · Cited by 128
Cited by
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Sridharan, A., Esposo, M., Kaushal, K., Tay, J., Osann, K., Agrawal, S., Gupta, S., & Agrawal, A. (2011) · AGE · doi:10.1007/s11357-010-9191-3 · Cited by 165
Metadata
- Authors
- Li, M., Liu, X., Zhou, Y., & Su, S. B.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03-20
- Volume
- 86
- Issue
- 1
- Pages
- 23-32
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2110809498
- Cited by
- 200
- References
- 3
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, M., Liu, X., Zhou, Y., & Su, S. B. (2009). Interferon-λs: the modulators of antivirus, antitumor, and immune responses. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.1208761
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