Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3
Open accessAbstract
In the present paper, we report the identification of a new gene encoding a transmembrane protein of 520 amino acids, showing 22% amino acid identity with the extracellular domain of the interleukin (IL)-20 receptor. This gene, termed likely interleukin or cytokine receptor-2 (LICR2), is located on chromosome 1, at 25kb from the IL22R (IL-22 receptor) gene, and is constitutively expressed in most tissues. A chimaeric receptor, consisting of the extracellular domain of the IL-10 receptorα chain and the intracellular domain of LICR2, activated signal transducer and activator of transcription (STAT)1, STAT2, STAT3 and STAT5 upon IL-10 stimulation, in a Janus kinase 1-dependent manner. In contrast, none of the IL-10-related cytokines described so far could activate LICR2-transfected cells, suggesting that LICR2 is a signalling receptor for a new cytokine of the IL-10 family.
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IL-22 mediates its functions by binding to its heterodimeric receptor consisting of IL-10 receptor β2 (IL-10Rβ2) and IL-22 receptor (IL-22R) and activating signaling pathways that stimulate STAT3 phosphorylation and nuclear translocation.
“IL-22 mediates its functions by binding to its heterodimeric receptor consisting of IL-10 receptor β2 (IL-10Rβ2) and IL-22 receptor (IL-22R) and activating signaling pathways, which stimulate STAT3 phosphorylation and nuclear translocation.80–84”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [81]
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- Authors
- DUMOUTIER, L., LEJEUNE, D., HOR, S., FICKENSCHER, H., & RENAULD, J.-C.
- Affiliations
- Ludwig Cancer Research (BE)
- Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, U.K.,
- Heidelberg University (DE)
- Corresponding author
- DUMOUTIER, Laure
- LEJEUNE, Diane
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2003-03-01
- Volume
- 370
- Issue
- 2
- Pages
- 391-396
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1223207
- OpenAlex
- W2119690091
- Cited by
- 128
- References
- 24
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 11 · 2014: 8 · 2013: 12 · 2012: 3
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT1, STAT2, STAT3, STAT5, chimeric receptors, JAK1, IL-10 family cytokines, transmembrane proteins, chromosome 1, gene cloning
- MeSH terms
- Cloning, Molecular, DNA-Binding Proteins, Humans, Molecular Sequence Data, Protein-Tyrosine Kinases, Transcription, Genetic, Signal Transduction, Trans-Activators, Interleukin-10, Protein Structure, Tertiary, Receptors, Cytokine, STAT1 Transcription Factor, STAT2 Transcription Factor, STAT3 Transcription Factor, Janus Kinase 1
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