The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Functional classification of interferon-stimulated genes identified using microarrays
Abstract
Interferons (IFNs) are a family of multifunctional cytokines thatactivate transcription of subsets of genes. The gene products inducedby IFNs are responsible for IFN antiviral, antiproliferative, andimmunomodulatory properties. To obtain a more comprehensive list and abetter understanding of the genes regulated by IFNs, we compiled datafrom many experiments, using two different microarray formats. Thecombined data sets identified >300 IFN-stimulated genes (ISGs). Toprovide new insight into IFN-induced cellular phenotypes, we assignedthese ISGs to functional categories. The data are accessible on the World Wide Web at http://www.lerner.ccf.org/labs/williams, including functional categories and individual genes listed in asearchable database. The entries are linked to GenBank and Unigenesequence information and other resources. The goal is to eventuallycompile a comprehensive list of all ISGs. Recognition of the functionsof the ISGs and their specific roles in the biological effects of IFNsis leading to a greater appreciation of the many facets of theseintriguing and essential cytokines. This review focuses on thefunctions of the ISGs identified by analyzing the microarray data andfocuses particularly on new insights into the protein kinaseRNA-regulated (PRKR) protein, which have been made possible with theavailability of PRKR-null mice.
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Cites
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Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
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Cited by
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion
Castro, F., Cardoso, A. P., Gonçalves, R. M., Serre, K., & Oliveira, M. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00847 · Cited by 1,224
Interferons at age 50: past, current and future impact on biomedicine
Borden, E. C., Sen, G. C., Uze, G., Silverman, R. H., Ransohoff, R. M., Foster, G. R., & Stark, G. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2422 · Cited by 1,154
Self-citationInterferon-Stimulated Genes: What Do They All Do?
Schoggins, J. W. (2019) · Annual Review of Virology · doi:10.1146/annurev-virology-092818-015756 · Cited by 1,036
Metadata
- Authors
- de Veer, M. J., Holko, M., Frevel, M., Walker, E., Der, S., Paranjape, J. M., Silverman, R. H., & Williams, B. R. G.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06-01
- Volume
- 69
- Issue
- 6
- Pages
- 912-920
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2119847512
- Cited by
- 900
- References
- 3
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- de Veer, M. J., Holko, M., Frevel, M., Walker, E., Der, S., Paranjape, J. M., Silverman, R. H., & Williams, B. R. G. (2001). Functional classification of interferon-stimulated genes identified using microarrays. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.69.6.912
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