HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works

The Biology of Vascular Endothelial Growth Factor

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

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Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

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Purification and Characterization of Hypoxia-inducible Factor 1

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Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., & Vaupel, P. W. (1996) · PubMed · Cited by 1,727 · see citing works

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674 · see citing works

PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632 · see citing works

HIF‐1α is required for solid tumor formation and embryonic vascularization

Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579 · see citing works

Positional Cloning of the Mouse Circadian Gene

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351 · see citing works

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

Huang, E. L., Arany, Z. P., Livingston, D. M., & Bunn, H. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.32253 · Cited by 1,190 · see citing works

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Gene Expression Profiles in Normal and Cancer Cells

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Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17771 · Cited by 1,106 · see citing works

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084 · see citing works

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the <i>VEGF</i> expression and is potentially involved in lung and vascular development

Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y., & Fujii-Kuriyama, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4273 · Cited by 1,016 · see citing works

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

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Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

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Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

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Stabilization of wild-type p53 by hypoxia-inducible factor 1α

An, W. G., Kanekal, M., Simon, M. C., Maltepe, E., Blagosklonny, M. V., & Neckers, L. Μ. (1998) · Nature · doi:10.1038/32925 · Cited by 820 · see citing works

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

Gerber, H.-P., Condorelli, F., Park, J., & Ferrara, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23659 · Cited by 794 · see citing works

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Lee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5375 · Cited by 782 · see citing works

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781 · see citing works

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

Wang, G., & Semenza, G. (1993) · Blood · doi:10.1182/blood.v82.12.3610.3610 · Cited by 766 · see citing works

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

Kallio, P. J., Wilson, W. J., O’Brien, S. L., Makino, Y., & Poellinger, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6519 · Cited by 754 · see citing works

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α

Kallio, P., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H., & Poellinger, L. (1998) · EMBO Journal · doi:10.1093/emboj/17.22.6573 · Cited by 707 · see citing works

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., & McKnight, S. L. (1998) · Genes &amp; Development · doi:10.1101/gad.12.21.3320 · Cited by 647 · see citing works

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

Yu, A. Y., Shimoda, L. A., Iyer, N. V., Huso, D. L., Sun, X., McWilliams, R. M., Beaty, T. H., Sham, J. S. K., Wiener, C. M., Sylvester, J. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5912 · Cited by 645 · see citing works

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

Feldser, D. M., Agani, F. H., Iyer, N. V., Pak, B. J., Ferreira, G., & Semenza, G. L. (1999) · PubMed · Cited by 638 · see citing works

Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

Wiesener, M. S., Turley, H., Allen, W. E., Willam, C., Eckardt, K., Talks, K., Wood, S. M., Gatter, K. C., Harris, A. L., Pugh, C. W., et al. (1998) · Blood · doi:10.1182/blood.v92.7.2260 · Cited by 629 · see citing works

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19253 · Cited by 629 · see citing works

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

Melillo, G., Musso, T., Sica, A., Taylor, L. S., Cox, G. W., & Varesio, L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1683 · Cited by 626 · see citing works

Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300

Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Poellinger, L., & Fujii‐Kuriyama, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1905 · Cited by 588 · see citing works

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

Gu, Y.-Z., Moran, S. M., Hogenesch, J. B., Wartman, L. D., & Bradfield, C. A. (1998) · Europe PMC (PubMed Central) · Cited by 577 · see citing works

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

Jiang, B., Agani, F. H., Passaniti, A., & Semenza, G. L. (1997) · PubMed · Cited by 532 · see citing works

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J., & Ratcliffe, P. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11205 · Cited by 526 · see citing works

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

Hogenesch, J. B., Chan, W. K., Jackiw, V., Brown, R. C., Gu, Y.-Z., Pray-Grant, M. G., Perdew, G. H., & Bradfield, C. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8581 · Cited by 514 · see citing works

Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Conaway, J. W., Klausner, R. D., & Pause, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12436 · Cited by 508 · see citing works

Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death

Kotch, L. E., Iyer, N. V., Laughner, E., & Semenza, G. L. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9253 · Cited by 418 · see citing works

In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1

Wiener, C. M., Booth, G., & Semenza, G. L. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1199 · Cited by 413 · see citing works

Induction of hypoxia‐inducible factor‐1 (HIF‐1) and its target genes following focal ischaemia in rat brain

Bergeron, M., Yu, A. Y., Solway, K., Semenza, G. L., & Sharp, F. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00845.x · Cited by 413 · see citing works

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1

Rolfs, A., Kvietikova, I., Gassmann, M., & Wenger, R. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20055 · Cited by 401 · see citing works

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1Preprint

Bhattacharya, S., Michels, C. L., Leung, M.-K., Arany, Z. P., Kung, A. L., & Livingston, D. M. (1999) · Genes & Development · doi:10.1101/gad.13.1.64 · Cited by 392 · see citing works

Perspectives on Oxygen Sensing

Semenza, G. L. (1999) · Cell · doi:10.1016/s0092-8674(00)81957-1 · Cited by 385 · see citing works

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activityPreprint

Lisztwan, J. H., Imbert, G., Wirbelauer, C., Gstaiger, M., & Krek, W. (1999) · Genes & Development · doi:10.1101/gad.13.14.1822 · Cited by 380 · see citing works

Identification of a hypoxia response element in the transferrin receptor gene

Lok, C. N., & Ponka, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24147 · Cited by 380 · see citing works

Transferrin Receptor Induction by Hypoxia

Tacchini, L., Bianchi, L., Bernelli-Zazzera, A., & Cairo, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24142 · Cited by 379 · see citing works

Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung

Yu, A. Y., Frid, M. G., Shimoda, L. A., Wiener, C. M., Stenmark, K. R., & Semenza, G. L. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.4.l818 · Cited by 370 · see citing works

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

Flamme, I., Fröhlich, T., von Reutern, M., Kappel, A., Damert, A., & Risau, W. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00674-6 · Cited by 366 · see citing works

Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse

Jain, S., Maltepe, E., Lu, M. M., Simon, C., & Bradfield, C. A. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00038-0 · Cited by 333 · see citing works

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

Palmer, L. A., Semenza, G. L., Stoler, M. H., & Johns, R. A. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.2.l212 · Cited by 327 · see citing works

Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression.

Ozaki, H., Yu, A. Y., Della, N. G., Ozaki, K., Luna, J. D., Yamada, H., Hackett, S. F., Okamoto, N., Zack, D. J., Semenza, G. L., et al. (1999) · PubMed · Cited by 326 · see citing works

cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix-Loop-Helix/PAS Factor (Arnt2) with Close Sequence Similarity to the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt)

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Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits

Takano, H., Manchikalapudi, S., Tang, X., Qiu, Y., Rizvi, A., Jadoon, A. K., Zhang, Q., & Bolli, R. (1998) · Circulation · doi:10.1161/01.cir.98.5.441 · Cited by 256 · see citing works

Hypoxia Regulates Expression of the Endothelin-1 Gene through a Proximal Hypoxia-Inducible Factor-1 Binding Site on the Antisense Strand

Hu, J. Y., Discher, D. J., Bishopric, N. H., & Webster, K. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8543 · Cited by 254 · see citing works

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

O'Rourke, J. F., Tian, Y.-M., Ratcliffe, P. J., & Pugh, C. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2060 · Cited by 242 · see citing works

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.

Zhong, H., Agani, F. H., Baccala, A. A., Laughner, E., Rioseco‐Camacho, N., Wb, I., Simons, J. W., & Semenza, G. L. (1998) · PubMed · Cited by 232 · see citing works

Adrenomedullin Gene Expression Is Developmentally Regulated and Induced by Hypoxia in Rat Ventricular Cardiac Myocytes

Cormier, S. A., Nguyen, S. V., & Claycomb, W. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17787 · Cited by 230 · see citing works

An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

Maulik, N., Sato, M., Price, B. D., & Das, D. K. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00632-2 · Cited by 229 · see citing works

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia

Tazuke, S. I., Mazure, N. M., Sugawara, J., Carland, G., Faessen, G. H., Suen, L.-F., Irwin, J. C., Powell, D. R., Giaccia, A. J., & Giudice, L. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10188 · Cited by 222 · see citing works

cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix–Loop–Helix/PAS Protein (BMAL1) and Identification of Alternatively Spliced Variants with Alternative Translation Initiation Site Usage

Ikeda, M., & Nomura, M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6371 · Cited by 220 · see citing works

Expression Patterns of Two Murine Homologs ofDrosophila Single-MindedSuggest Possible Roles in Embryonic Patterning and in the Pathogenesis of Down Syndrome

Fan, C., Kuwana, E., Bulfone, A., Fletcher, C., Copeland, N. G., Jenkins, N. A., Crews, S. T., Martı́nez, S., Puelles, L., Rubenstein, J. L. R., et al. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0037 · Cited by 199 · see citing works

Remembrance of things PAS: regulation of development by bHLH–PAS proteins

Crews, S. T., & Fan, C. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00003-9 · Cited by 198 · see citing works

Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system

Zhou, Y.-D., Barnard, M., Tian, H., Li, X., Ring, H. Z., Francke, U., Shelton, J. M., Richardson, J. A., Russell, D. W., & McKnight, S. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.713 · Cited by 195 · see citing works

Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α)

Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H., & Ratcliffe, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8360 · Cited by 189 · see citing works

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

Halterman, M. W., Miller, C. C., & Federoff, H. J. (1999) · PubMed Central · doi:10.1523/jneurosci.19-16-06818.1999 · Cited by 184 · see citing works

Expression Patterns of Two Murine Homologs ofDrosophila Single-MindedSuggest Possible Roles in Embryonic Patterning and in the Pathogenesis of Down Syndrome

Fan, C., Kuwana, E., Bulfone, A., Fletcher, C., Copeland, N. G., Jenkins, N. A., Crews, S. T., Martı́nez, S., Puelles, L., Rubenstein, J. L. R., et al. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0001 · Cited by 164 · see citing works

Transcriptionally Active Heterodimer Formation of an Arnt-like PAS Protein, Arnt3, with HIF-1a, HLF, and Clock

Takahata, S., Sogawa, K., Kobayashi, A., Ema, M., Mimura, J., Ozaki, N., & Fujii‐Kuriyama, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9012 · Cited by 153 · see citing works

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

Martin, C., Yu, A. Y., Jiang, B., Davis, L. E., Kimberly, D. J., Hohimer, A. R., & Semenza, G. L. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70433-8 · Cited by 145 · see citing works

Nucleotide Sequence, Chromosomal Assignment and mRNA Expression of Mouse Hypoxia-Inducible Factor-1α

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Characterization of the α 1B -adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

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Transcription Factors and Human Disease

Semenza, G. L. (1998) · Cited by 39 · see citing works

Oxygen regulation of ion channels and gene expression

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Free radicals and antioxidants in normal physiological functions and human disease

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Free Radicals in the Physiological Control of Cell Function

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Free radicals, metals and antioxidants in oxidative stress-induced cancer

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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