The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Negative regulation of cytokine signaling
Abstract
Cytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mechanism of activation. Rapid and efficient attenuation of cytokine signals is crucial to maintaining regulation of these processes and to preventing toxic side effects. Phosphatases have been shown to be involved in these regulatory processes, but more recent research has seen the discovery of two new families of negative regulators, the suppressor of cytokine signaling (SOCS) and protein inhibitors of signal transducer and activator of transcription (STAT) (PIAS) protein families. SOCS proteins are induced by and inhibit many cytokine-signaling systems in a classic negative-feedback loop, and the generation of transgenic and knockout models has greatly increased our understanding of their physiological functions. PIAS proteins interact with the transcriptional mediators of cytokine action, the STATs, to suppress their DNA-binding activity. These three classes of molecules form what is now emerging as an integrated system for deactivating cytokine signaling at a number of levels, from the receptor to the transcription factor.
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“Activation of cytokine signaling is coupled with multiple layers of negative regulation to ensure timely down-regulation of signaling, as exemplified by the SOCS system (17).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [17]
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The JAK/STAT signaling pathway
Rawlings, J. S., Rosler, K. M., & Harrison, D. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.00963 · Cited by 1,858
Regulation of JAK–STAT signalling in the immune system
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Buettner, R., Mora, L. B., & Jove, R. (2002) · PubMed · Cited by 1,036
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
Taniguchi, K., & Karin, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.001 · Cited by 724
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
Junttila, I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00888 · Cited by 687
Metadata
- Authors
- Greenhalgh, C. J., & Hilton, D. J.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- Corresponding author
- Greenhalgh, Christopher J
- ORCID
- Hilton, Douglas J
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09-01
- Volume
- 70
- Issue
- 3
- Pages
- 348-356
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2107469094
- Cited by
- 258
- References
- 93
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 11 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 11 · 2012: 13
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Anti-Cancer Council of Victoria, Melbourne, Australia
- National Health and Medical Research Council, Canberra, Australia
- National Institutes of Health (CA-22556)
- Australian Federal Government Cooperative Research Centers Program
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- cytokine signaling, negative regulation, suppressor of cytokine signaling, STAT proteins, negative feedback loop, signal attenuation, protein phosphatase, transcriptional repression, DNA-binding activity
- MeSH terms
- Suppressor of Cytokine Signaling 1 Protein, Suppressor of Cytokine Signaling 3 Protein, Animals, Carrier Proteins, DNA-Binding Proteins, Models, Biological, Proteins, Repressor Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Cytokines, Protein Tyrosine Phosphatases, Intracellular Signaling Peptides and Proteins, Suppressor of Cytokine Signaling Proteins, Protein Inhibitors of Activated STAT, Mice
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