Specific Inhibition of Stat3 Signal Transduction by PIAS3
Abstract
The signal transducer and activator of transcription-3 (Stat3) protein is activated by the interleukin 6 (IL-6) family of cytokines, epidermal growth factor, and leptin. A protein named PIAS3 (protein inhibitor of activated STAT) that binds to Stat3 was isolated and characterized. The association of PIAS3 with Stat3 in vivo was only observed in cells stimulated with ligands that cause the activation of Stat3. PIAS3 blocked the DNA-binding activity of Stat3 and inhibited Stat3-mediated gene activation. Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3.
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PIAS3 binds specifically to STAT3 and abrogates its activity.
“Members of the protein inhibitor of activated STAT (PIAS) family, especially PIAS3, are small ubiquitin-like modifier-E3 ligases that bind specifically to STAT3 and abrogate its activity.15”
From Critical analysis of the potential for targeting STAT3 in human malignancy (2013) · cites this paper as [15]
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070 · see citing works
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974 · see citing works
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808 · see citing works
Targeted disruption of the mouse <i>Stat3</i> gene leads to early embryonic lethality
Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3801 · Cited by 1,323 · see citing works
Structure and function of a new STAT-induced STAT inhibitor
Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,287 · see citing works
Ihle, J. N. (1995) · Nature · doi:10.1038/377591a0 · Cited by 1,235 · see citing works
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086 · see citing works
Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., We, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., & Kishimoto, T. (1994) · Cell · doi:10.1016/0092-8674(94)90235-6 · Cited by 1,019 · see citing works
Chen, C. A., & Okayama, H. (1990) · PubMed · Cited by 898 · see citing works
A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ
Shuai, K., Stark, G. R., Kerr, L. M., & Darnell, J. E. (1993) · Science · doi:10.1126/science.7690989 · Cited by 802 · see citing works
Self-citationActivation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.
Shuai, K., Schindler, C., Prezioso, V., & Darnell, J. (1992) · Science · doi:10.1126/science.1281555 · Cited by 784 · see citing works
Self-citationA common nuclear signal transduction pathway activated by growth factor and cytokine receptors.
Sadowski, H., Shuai, K., Darnell, J., & Gilman, M. (1993) · Science · doi:10.1126/science.8397445 · Cited by 682 · see citing works
Self-citationStat3 and Stat4: members of the family of signal transducers and activators of transcription.
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4806 · Cited by 397 · see citing works
Léveillard, T., & Verma, I. M. (1993) · Europe PMC (PubMed Central) · Cited by 18 · see citing works
O’Shea, J. J. (1997) · Immunity · doi:10.1016/s1074-7613(00)80365-9 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · see citing works
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201 · see citing works
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130 · see citing works
Bôle-Feysot, C., Goffin, V., Edery, M., Binart, N., & Kelly, P. (1998) · Endocrine reviews · doi:10.1210/edrv.19.3.0334 · Cited by 1,973 · see citing works
Jaks and STATs: biological implications.
Leonard, W., & O'Shea, J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.293 · Cited by 1,939 · see citing works
Interferons, interferon‐like cytokines, and their receptors
Pestka, S., Krause, C. D., & Walter, M. R. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00204.x · Cited by 1,768 · see citing works
Johnson, E. S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074118 · Cited by 1,675 · see citing works
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works
“A protein inhibitor of activated STAT (PIAS) is also known to be a direct inhibitor of STAT3 (125).”
BackgroundRegulation of JAK–STAT signalling in the immune system
Shuai, K., & Liu, B. (2003) · Nature reviews. Immunology · doi:10.1038/nri1226 · Cited by 1,379 · see citing works
Self-citationHirano, T., Ishihara, K., & Hibi, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203551 · Cited by 1,195 · see citing works
Signaling through the JAK/STAT pathway, recent advances and future challenges
Kisseleva, T., Bhattacharya, S., Braunstein, J., & Schindler, C. (2002) · Gene · doi:10.1016/s0378-1119(02)00398-0 · Cited by 1,158 · see citing works
Buettner, R., Mora, L. B., & Jove, R. (2002) · PubMed · Cited by 1,021 · see citing works
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943 · see citing works
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
Seif, F., Khoshmirsafa, M., Aazami, H., Mohsenzadegan, M., Sedighi, G. R., & Bahar, M. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-017-0177-y · Cited by 774 · see citing works
Inhibition of Stat1-mediated gene activation by PIAS1
Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D., & Shuai, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10626 · Cited by 765 · see citing works
Self-citationSUMO and ubiquitin in the nucleus: different functions, similar mechanisms?Preprint
Gill, G. (2004) · Genes & Development · doi:10.1101/gad.1214604 · Cited by 752 · see citing works
Signal Transduction and the Control of Gene Expression
Brivanlou, A. H., & Darnell, J. E. (2002) · Science · doi:10.1126/science.1066355 · Cited by 699 · see citing works
Nuclear and unclear functions of SUMO
Seeler, J.-S., & Dejean, A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1200 · Cited by 667 · see citing works
Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer
Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Gupta, S. R., Tharakan, S. T., Koca, C., Dey, S., & Sung, B. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04911.x · Cited by 652 · see citing works
IL-13 receptors and signaling pathways: An evolving web
Hershey, G. K. K. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1333 · Cited by 612 · see citing works
Imada, K., & Leonard, W. J. (2000) · Molecular Immunology · doi:10.1016/s0161-5890(00)00018-3 · Cited by 610 · see citing works
STAT proteins: From normal control of cellular events to tumorigenesis
Calò, V., Migliavacca, M., Bazan, V., Macaluso, M., Buscemi, M., Gebbia, N., & Russo, A. D. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10364 · Cited by 606 · see citing works
Negative Regulation of Cytokine Signaling Pathways
Yasukawa, H., Sasaki, A. T., & Yoshimura, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.143 · Cited by 596 · see citing works
Genomic Analysis of Mouse Retinal Development
Blackshaw, S., Harpavat, S., Trimarchi, J. M., Cai, L., Huang, H., Kuo, W. P., Weber, G. M., Lee, K., Fraioli, R. E., Cho, S., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020247 · Cited by 586 · see citing works
Regulation of intercellular adhesion molecule-1 (CD54) gene expression
Roebuck, K. A., & Finnegan, A. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.6.876 · Cited by 558 · see citing works
Zhu, L., Nie, L., Zhu, G., Xiang, L., & Shao, J.-Z. (2012) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2012.04.001 · Cited by 550 · see citing works
Sachdev, S., Bruhn, L., Sieber, H., Pichler, A., Melchior, F., & Grosschedl, R. (2001) · Genes & Development · doi:10.1101/gad.944801 · Cited by 549 · see citing works
Estrogen Regulation of Growth Hormone Action
Leung, K., Johannsson, G., Leong, G. M., & Ho, K. K. Y. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0035 · Cited by 544 · see citing works
The Role of Prolactin in Mammary Carcinoma
Clevenger, C. V., Furth, P. A., Hankinson, S. E., & Schuler, L. A. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0036 · Cited by 542 · see citing works
Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies
Sansone, P., & Bromberg, J. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.8907 · Cited by 511 · see citing works
Interleukin-6: Biology, signaling and strategies of blockade
Schaper, F., & Rose‐John, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.004 · Cited by 513 · see citing works
SAP – a putative DNA-binding motif involved in chromosomal organization
Aravind, L., & Koonin, E. V. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01537-6 · Cited by 502 · see citing works
Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map
Huynh, J., Chand, A. L., Gough, D. J., & Ernst, M. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0090-8 · Cited by 507 · see citing works
Interleukin-6: discovery of a pleiotropic cytokine
Kishimoto, T. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1916 · Cited by 559 · see citing works
Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription
Mowen, K. A., Tang, J., Zhu, W. Z., Schurter, B. T., Shuai, K., Herschman, H. R., & David, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00269-0 · Cited by 484 · see citing works
Self-citationThe paradigm of IL-6: from basic science to medicine.
Naka, T., Nishimoto, N., & Kishimoto, T. (2002) · Arthritis Research · doi:10.1186/ar565 · Cited by 480 · see citing works
Biology and significance of the JAK/STAT signalling pathways
Kiu, H., & Nicholson, S. E. (2012) · Growth Factors · doi:10.3109/08977194.2012.660936 · Cited by 470 · see citing works
Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53
Kahyo, T., Nishida, T., & Yasuda, H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00349-5 · Cited by 449 · see citing works
STAT3 Target Genes Relevant to Human Cancers
Carpenter, R., & Lo, H.-W. (2014) · Cancers · doi:10.3390/cancers6020897 · Cited by 511 · see citing works
Regulation of gene-activation pathways by PIAS proteins in the immune system
Shuai, K., & Liu, B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1667 · Cited by 447 · see citing works
Self-citationMembers of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity
Schmidt, D., & Müller, S. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052559499 · Cited by 449 · see citing works
Inhibitors of Cytokine Signal Transduction
Wormald, S., & Hilton, D. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r300030200 · Cited by 440 · see citing works
The SOCS box: a tale of destruction and degradation
Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M., & Hilton, D. J. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02085-6 · Cited by 433 · see citing works
Haura, E. B., Turkson, J., & Jove, R. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0195 · Cited by 430 · see citing works
PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases
Kotaja, N., Karvonen, U., Jänne, O. A., & Palvimo, J. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5222-5234.2002 · Cited by 426 · see citing works
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
Yang, J., Chatterjee-Kishore, M., Staugaitis, S. M., Nguyen, H., Schlessinger, K., Levy, D. E., & Stark, G. R. (2005) · Cancer Research · doi:10.1158/0008-5472.939.65.3 · Cited by 405 · see citing works
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
UNGER, R. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.09.008 · Cited by 399 · see citing works
Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer
Aggarwal, B. B., Sethi, G., Ahn, K. S., Sandur, S. K., Pandey, M. K., Kunnumakkara, A. B., Sung, B., & Ichikawa, H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1378.063 · Cited by 399 · see citing works
Song, M. M., & Shuai, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35056 · Cited by 396 · see citing works
Self-citationRole of STAT3 in Cancer Metastasis and Translational Advances
Kamran, M., Patil, P., & Gude, R. (2013) · BioMed Research International · doi:10.1155/2013/421821 · Cited by 376 · see citing works
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12848 · Cited by 388 · see citing works
Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder
Selman, M., & Pardo, A. (2001) · Respiratory Research · doi:10.1186/rr175 · Cited by 381 · see citing works
The role of Stat5a and Stat5b in signaling by IL-2 family cytokines
Lin, J., & Leonard, W. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203523 · Cited by 369 · see citing works
You, M., Yu, D.-H., & Feng, G.-S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2416 · Cited by 364 · see citing works
Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
Sahu, A. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.10.001 · Cited by 351 · see citing works
Functional Roles of STAT Family Proteins: Lessons from Knockout Mice
Akira, S. (1999) · Stem Cells · doi:10.1002/stem.170138 · Cited by 349 · see citing works
Roles of unphosphorylated STATs in signaling
Yang, J., & Stark, G. R. (2008) · Cell Research · doi:10.1038/cr.2008.41 · Cited by 347 · see citing works
Harris, M., Aschkenasi, C., Elias, C. F., Chandrankunnel, A., Nillni, E. A., Bjørbæk, C., Elmquist, J. K., Flier, J. S., & Hollenberg, A. N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10741 · Cited by 341 · see citing works
Kern, L., Mittenbühler, M., Vesting, A., Ostermann, A., Wunderlich, C., & Wunderlich, F. (2018) · Cancers · doi:10.3390/cancers11010024 · Cited by 331 · see citing works
Signal transducer and activator of transcription proteins in leukemias
Beneklı, M., Baer, M. R., Baumann, H., & Wetzler, M. (2003) · Blood · doi:10.1182/blood-2002-04-1204 · Cited by 326 · see citing works
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer
Wang, S., & Sun, Y. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2259 · Cited by 321 · see citing works
The Jak-Stat pathway in normal and perturbed hematopoiesis
Ward, A. C., Touw, I. P., & Yoshimura, A. (2000) · Blood · doi:10.1182/blood.v95.1.19.001k34_19_29 · Cited by 314 · see citing works
Modulation of STAT signaling by STAT-interacting proteins
Shuai, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203522 · Cited by 379 · see citing works
Self-citationSTAT family of transcription factors in cytokine-mediated biological responses
Takeda, K., & Akira, S. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00005-8 · Cited by 310 · see citing works
IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment
Manore, S. G., Doheny, D. L., Wong, G. L., & Lo, H.-W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.866014 · Cited by 280 · see citing works
Functional Association of Nmi with Stat5 and Stat1 in IL-2- and IFN γ-Mediated Signaling
Zhu, M., John, S., Berg, M., & Leonard, W. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80965-4 · Cited by 305 · see citing works
Acquiring signalling specificity from the cytokine receptor gp130
Ernst, M. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.11.003 · Cited by 297 · see citing works
Structure, function, and biology of SHIP proteins
Rohrschneider, L. R., Fuller, J. F., Wolf, I., Liu, Y., & Lucas, D. M. (2000) · Genes & Development · doi:10.1101/gad.14.5.505 · Cited by 294 · see citing works
An aberrant STAT pathway is central to COVID-19
Matsuyama, T., Kubli, S. P., Yoshinaga, S. K., Pfeffer, K., & Mak, T. W. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00633-7 · Cited by 292 · see citing works
Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway
Heim, M. H., Moradpour, D., & Blum, H. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8469-8475.1999 · Cited by 287 · see citing works
Capacitative calcium entry channels
Putney, J. W., & McKay, R. R. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199901)21:1 · Cited by 373 · see citing works
Structures and biological functions of IL-31 and IL-31 receptors
Zhang, Q., Putheti, P., Zhou, Q., Liu, Q., & Gao, W. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.003 · Cited by 286 · see citing works
PIAS/SUMO: new partners in transcriptional regulation
Schmidt, D., & M�ller, S. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3129-1 · Cited by 285 · see citing works
PIAS proteins: pleiotropic interactors associated with SUMO
Rytinki, M. M., Kaikkonen, S., Pehkonen, P., Jääskeläinen, T. J., & Palvimo, J. J. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0061-z · Cited by 279 · see citing works
Subramaniam, A., Shanmugam, M. K., Perumal, E., Li, F., Nachiyappan, A., Dai, X., Swamy, S. N., Ahn, K. S., Kumar, A. P., Tan, B. K. H., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.10.002 · Cited by 281 · see citing works
Functional domains in plant shoot meristems
Brand, U., Hobe, M., & Simon, R. G. (2001) · BioEssays · doi:10.1002/1521-1878(200102)23:2 · Cited by 49 · see citing works
Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
Ng, D. C. H., Li-n, B., Lim, C. P., Huang, G., Zhang, T., Poli, V., & Cao, X. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200503021 · Cited by 276 · see citing works
Tang, L.-Y., Heller, M., Meng, Z., Yu, L., Tang, Y., Zhou, M., & Zhang, Y. E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.773085 · Cited by 278 · see citing works
Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery
Hu, Y., Dong, Z., & Liu, K. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-02949-5 · Cited by 288 · see citing works
Peterson, W. M., Wang, Q., Tzekova, R., & Wiegand, S. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04081.2000 · Cited by 267 · see citing works
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
Liu, B., Mink, S. R., Wong, K. A., Stein, N., Getman, C., Dempsey, P. W., Wu, H., & Shuai, K. (2004) · Nature Immunology · doi:10.1038/ni1104 · Cited by 271 · see citing works
Self-citationDohmen, R. J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.021 · Cited by 270 · see citing works
The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus.
Heim, M. (1999) · Journal of Receptor and Signal Transduction Research · doi:10.3109/10799899909036638 · Cited by 300 · see citing works
STAT3, stem cells, cancer stem cells and p63
Galoczová, M., Coates, P. J., & Vojtěšek, B. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0078-0 · Cited by 266 · see citing works
IL-6 signal transduction and its physiological roles: the signal orchestration model
Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673 · see citing works
Cohney, S., Sanden, D., Cacalano, N., Yoshimura, A., Mui, A., Migone, T., & Johnston, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4980 · Cited by 293 · see citing works
Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function
Auernhammer, C. J., & Melmed, S. K. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.3.0400 · Cited by 263 · see citing works
A Novel Type of E3 Ligase for the Ufm1 Conjugation System
Tatsumi, K., Sou, Y., Tada, N., Nakamura, E., Iemura, S.-I., Natsume, T., Kang, S. H., Chung, C. H., Kasahara, M., Kominami, E., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.036814 · Cited by 262 · see citing works
Self-citationTranscription factor Sp3 is silenced through SUMO modification by PIAS1
Sapetschnig, A., Rischitor, G., Braun, H., Doll, A., Schergaut, M., Melchior, F., & Suske, G. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf510 · Cited by 262 · see citing works
Zhang, Q., Raghunath, P. N., Xue, L., Majewski, M., Carpentieri, D. F., Ødum, N., Morris, S. W., Skórski, T., & Wasik, M. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.466 · Cited by 261 · see citing works
Franchimont, D. P., Galon, J., Gadina, M., Visconti, R., Zhou, Y.-J., Aringer, M., Frucht, D. M., Chrousos, G. P., & O’Shea, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1768 · Cited by 261 · see citing works
Negative regulation of cytokine signaling
Greenhalgh, C. J., & Hilton, D. J. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.3.348 · Cited by 258 · see citing works
SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin μ gene expressionPreprint
Dobreva, G. D., Dambacher, J., & Grosschedl, R. (2003) · Genes & Development · doi:10.1101/gad.1153003 · Cited by 255 · see citing works
JAK/STAT signal transduction: Regulators and implication in hematological malignancies
Valentino, L., & Pierre, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.017 · Cited by 252 · see citing works
Yamamoto, T., Sekine, Y., Kashima, K., Kubota, A., Sato, N., Aoki, N., & Matsuda, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02291-x · Cited by 250 · see citing works
Huang, S. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2313 · Cited by 249 · see citing works
Leptin‐induced signal transduction pathways
Hegyi, K., Fülöp, K., Kovács, K., Tóth, S., & Falus, A. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2003.12.003 · Cited by 246 · see citing works
Jackson, P. K. (2001) · Genes & Development · doi:10.1101/gad.955501 · Cited by 244 · see citing works
Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?
Jarnicki, A., Putoczki, T. L., & Ernst, M. (2010) · Cell Division · doi:10.1186/1747-1028-5-14 · Cited by 240 · see citing works
- Authors
- Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., & Shuai, K.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Chung, Chan D.
- Liao, Jiayu
- Shuai, Ke
- Venue
- Science
- Published
- 1997-12-05
- Volume
- 278
- Issue
- 5344
- Pages
- 1803-1805
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993520606
- Cited by
- 980
- References
- 17
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 18 · 2022: 21 · 2021: 27 · 2020: 29 · 2019: 26 · 2018: 28 · 2017: 23 · 2016: 26 · 2015: 30 · 2014: 41 · 2013: 47 · 2012: 35
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01ai039612-01)
- National Cancer Institute (T32CA09056, T32CA009056)
- National Institute of Allergy and Infectious Diseases (AI39612)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT3, PIAS3, signal transduction inhibition, interleukin-6 family cytokines, epidermal growth factor, leptin, STAT1, transcriptional regulation
- MeSH terms
- Amino Acid Sequence, Animals, Carrier Proteins, Cell Line, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Phosphoproteins, Phosphorylation, Recombinant Fusion Proteins, Transfection, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Signal Transduction, Transcriptional Activation, Trans-Activators, Interleukin-6, NF-kappa B, Interferon-alpha, Phosphotyrosine, Intracellular Signaling Peptides and Proteins, STAT1 Transcription Factor, STAT3 Transcription Factor, Protein Inhibitors of Activated STAT, Interferon Regulatory Factor-1, Mice
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