The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Multiple control of interleukin-8 gene expression
Abstract
Interleukin (IL)-8, a prototypic human chemokine, was detected more than a decade ago as the founding member of the chemokine superfamily. One of the most remarkable properties of IL-8 is the variation of its expression levels. In healthy tissues, IL-8 is barely detectable, but it is rapidly induced by ten- to 100-fold in response to proinflammatory cytokines such as tumor necrosis factor or IL-1, bacterial or viral products, and cellular stress. Recently, significant advances in the understanding of signaling pathways, which coordinately regulate IL-8 transcription as well as mRNA stabilization in response to external stimuli, have been made. Maximal IL-8 amounts are generated by a combination of three different mechanisms: first, derepression of the gene promoter; second, transcriptional activation of the gene by nuclear factor-κB and JUN-N-terminal protein kinase pathways; and third, stabilization of the mRNA by the p38 mitogen-activated protein kinase pathway. In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury.
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“binding sites for C/EBPβ and NF-κB are present in neighboring positions in the IL-8 and GROα promoters and these transcription factors regulate synergistically IL-8 and GROα during viral infection and stress (Hoffmann et al., 2002”
From Chemokine signaling via the CXCR2 receptor reinforces senescence (2008) · cites this paper as Hoffmann et al., 2002
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Cytokines in Inflammatory Disease
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Metadata
- Authors
- Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Institute of Pharmacology, Medical School Hannover , Germany
- Corresponding author
- Kracht, Michael
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 72
- Issue
- 5
- Pages
- 847-855
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2149122802
- Cited by
- 1,058
- References
- 87
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 17 · 2023: 35 · 2022: 37 · 2021: 35 · 2020: 31 · 2019: 35 · 2018: 37 · 2017: 39 · 2016: 49 · 2015: 79 · 2014: 64 · 2013: 54 · 2012: 39
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-8, chemokines, gene expression regulation, transcriptional activation, NF-κB, JNK signaling, p38 MAPK, mRNA stabilization, inflammatory cytokines, chemokine induction, leukocyte recruitment
- MeSH terms
- Animals, Base Sequence, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Repressor Proteins, Transcription Factors, Transcription, Genetic, Signal Transduction, Transcriptional Activation, Interleukin-8, NF-kappa B, RNA Stability, Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, Mice
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