The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Multiple control of interleukin-8 gene expression
Abstract
Interleukin (IL)-8, a prototypic human chemokine, was detected more than a decade ago as the founding member of the chemokine superfamily. One of the most remarkable properties of IL-8 is the variation of its expression levels. In healthy tissues, IL-8 is barely detectable, but it is rapidly induced by ten- to 100-fold in response to proinflammatory cytokines such as tumor necrosis factor or IL-1, bacterial or viral products, and cellular stress. Recently, significant advances in the understanding of signaling pathways, which coordinately regulate IL-8 transcription as well as mRNA stabilization in response to external stimuli, have been made. Maximal IL-8 amounts are generated by a combination of three different mechanisms: first, derepression of the gene promoter; second, transcriptional activation of the gene by nuclear factor-κB and JUN-N-terminal protein kinase pathways; and third, stabilization of the mRNA by the p38 mitogen-activated protein kinase pathway. In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“binding sites for C/EBPβ and NF-κB are present in neighboring positions in the IL-8 and GROα promoters and these transcription factors regulate synergistically IL-8 and GROα during viral infection and stress (Hoffmann et al., 2002”
From Chemokine signaling via the CXCR2 receptor reinforces senescence (2008) · cites this paper as Hoffmann et al., 2002
Citations
Cites
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,923
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279
Ninomiya‐Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., & Matsumoto, K. (1999) · Nature · doi:10.1038/18465 · Cited by 1,187
Research works printed but not linked: 29
- Kasahara, 1991, Immunology, 74, 60
- Aihara, 1997, Inf, Immun., 65, 3218
- Lee, 1997, Mol, Cell. Biol., 17, 5097
- Holtmann, 1999, Mol, Cell. Biol., 19, 6742
- Albanyan, 2000, Infect, Immun., 68, 2053
- Marie, 1999, Infect, Immun., 67, 688
- Feoktistov, 1999, Mol, Pharmacol., 55, 726
- Shono, 1996, Mol, Cell. Biol., 16, 4231
- Yoshida, 1997, Mol, Cell. Biol., 17, 4015
- Kunsch, 1993, Mol, Cell. Biol., 13, 6137
- Huang, 2000, Cytokines Cell, Mol. Ther., 6, 9
- Yu, 2001, Inflamm, Res., 50, 220
- Bocker, 2000, J, Biol. Chem., 275, 12207
- Li, 1999, Infect, Immun., 67, 3893
- Schmitz, 2001, Trends Biochem, Sci., 26, 186
- Matsukaka, 1993, Proc, Natl. Acad. Sci. USA, 90, 10193
- Ashburner, 2001, Mol, Cell. Biol., 21, 7065
- Stein, 1993, Mol, Cell. Biol., 13, 7191
- Vanden Berghe, 1999, J, Biol. Chem., 274, 32091
- Zandi, 1999, Mol, Cell. Biol., 19, 4547
- Nebreda, 2000, Trends Biochem, Sci., 25, 257
- Schmidt-Supprian, 2000, Mol, Cell, 5, 981
- Kracht, 2000, Eur, Cytokine Netw., 11, 497
- Wathelet, 1998, Mol, Cell, 1, 507
- Falvo, 2000, Mol, Cell. Biol., 20, 4814
- Zhong, 1998, Mol, Cell, 1, 661
- Merika, 1998, Mol, Cell, 1, 277
- Davies, 2000, Biochem, J., 351, 95
- Widmann, 1999, Physiol, Rev., 79, 143
Cited by
Sorted by citations
Cytokines in Inflammatory Disease
Kany, S., Vollrath, J. T., & Relja, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236008 · Cited by 1,761
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801
Weber, A., Wasiliew, P., & Kracht, M. (2010) · Science Signaling · doi:10.1126/scisignal.3105cm1 · Cited by 962
Self-citationRas-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, A., & Bar‐Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 880
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
Ha, H., Debnath, B., & Neamati, N. (2017) · Theranostics · doi:10.7150/thno.15625 · Cited by 805
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
Ehses, J. A., Perren, A. A., Eppler, E., Ribaux, P., Pospisilik, J. A., Maor-Cahn, R., Guéripel, X., Ellingsgaard, H., Schneider, M. K. J., Biollaz, G., et al. (2007) · Diabetes · doi:10.2337/db06-1650 · Cited by 802
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
Brat, D. J., Bellail, A. C., & Meir, E. G. V. (2005) · Neuro-Oncology · doi:10.1215/s1152851704001061 · Cited by 760
Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications
Kanoh, S., & Rubin, B. K. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00078-09 · Cited by 722
Guillot, L., Le Goffic, R., Bloch, S., Escriou, N., Akira, S., Chignard, M., & Si-Tahar, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410592200 · Cited by 689
Imamura, K., Imamachi, N., Akizuki, G., Kumakura, M., Kawaguchi, A., Nagata, K., Kato, A., Kawaguchi, Y., Sato, H., Yoneda, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.009 · Cited by 688
Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 701
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
Wang, L., Luo, J., Li, B., Tian, X. Y., Chen, L., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., et al. (2016) · Nature · doi:10.1038/nature20602 · Cited by 666
The CXCL8-CXCR1/2 pathways in cancer
Liu, Q., Li, A., Tian, Y., Wu, J. D., Liu, Y., Li, T., Chen, Y., Han, X., & Wu, K. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.08.002 · Cited by 671
Cambier, S., Gouwy, M., & Proost, P. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00974-6 · Cited by 605
Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells
Park, E., Yi, J., Chung, K., Ryu, D., Choi, J., & Park, K. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.06.869 · Cited by 563
Interleukin-8: An evolving chemokine
Matsushima, K., Yang, D., & Oppenheim, J. J. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155828 · Cited by 527
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
Lu, H., Clauser, K. R., Tam, W. L., Fröse, J., Ye, X., Eaton, E. N., Reinhardt, F., Donnenberg, V. S., Bhargava, R., Carr, S. A., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3041 · Cited by 464
Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response
de Oliveira, S., Reyes‐Aldasoro, C. C., Candel, S., Renshaw, S. A., Mulero, V., & Calado, Â. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203266 · Cited by 385
Arbibe, L., Kim, D. W., Batsché, É., Pédron, T., Mateescu, B., Muchardt, C., Parsot, C., & Sansonetti, P. J. (2006) · Nature Immunology · doi:10.1038/ni1423 · Cited by 376
Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L. J., Meltzer, J., Garza, D., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932773100 · Cited by 370
Buss, H., Dörrie, A., Schmitz, M. L., Hoffmann, E., Resch, K., & Kracht, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409825200 · Cited by 362
Self-citationGuillot, L., Medjane, S., Le-Barillec, K., Balloy, V., Danel, C. J., Chignard, M., & Si‐Tahar, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305790200 · Cited by 360
Lohmann, N., Schirmer, L., Atallah, P., Wandel, E., Ferrer, R. A., Werner, C., Simon, J. C., Franz, S., & Freudenberg, U. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai9044 · Cited by 360
Expression and function of Toll-like receptors 2 and 4 in human keratinocytes
Pivarcsi, A. (2003) · International Immunology · doi:10.1093/intimm/dxg068 · Cited by 352
Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
Cheng, Y., Ma, X., Wei, Y.-Q., & Wei, X. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.01.005 · Cited by 352
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
Wang, D., Wang, H., Brown, J. R., Daikoku, T., Wei, N., Shi, Q., Richmond, A. J., Strieter, R. M., Dey, S. K., & DuBois, R. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052124 · Cited by 337
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis
Ishizu, T., Osoegawa, M., Mei, F.-J., Kikuchi, H., Tanaka, M., Takakura, Y., Minohara, M., Murai, H., Mihara, F., Taniwaki, T., et al. (2005) · Brain · doi:10.1093/brain/awh453 · Cited by 335
RelB, a New Partner of Aryl Hydrocarbon Receptor-Mediated Transcription
Vogel, C. F. A., Sciullo, E. M., Li, W., Wong, P., Lazennec, G., & Matsumura, F. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0211 · Cited by 332
duPont, N. C., Wang, K., Wadhwa, P. D., Culhane, J. F., & Nelson, E. L. (2005) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2005.03.005 · Cited by 325
Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor
So, A. Y., Chaivorapol, C., Bolton, E. C., Li, H., & Yamamoto, K. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030094 · Cited by 304
Influenza Virus Evades Innate and Adaptive Immunity via the NS1 Protein
Fernández-Sesma, A., Marukian, S., Ebersole, B. J., Kaminski, D. A., Park, M., Yuen, T., Sealfon, S. C., García‐Sastre, A., & Moran, T. M. (2006) · Journal of Virology · doi:10.1128/jvi.02381-05 · Cited by 305
NK Cell Compartments and Their Activation by Dendritic Cells
Ferlazzo, G., & Münz, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1333 · Cited by 304
Cronin, J., Turner, M. L., Goetze, L., Bryant, C. E., & Sheldon, I. M. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.092718 · Cited by 284
Qazi, B. S., Tang, K., & Qazi, A. S. (2011) · International Journal of Inflammation · doi:10.4061/2011/908468 · Cited by 271
IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy
Teijeira, Á., Garasa, S., Ochoa, M. C., Villalba-Esparza, M., Olivera, I., Cirella, A., Eguren‐Santamaría, I., Berraondo, P., Schalper, K. A., de Andrea, C. E., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1319 · Cited by 275
NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
Kreuz, S., Siegmund, D., Rumpf, J., Samel, D., Leverkus, M., Janßen, O., Häcker, G. A., Dittrich‐Breiholz, O., Kracht, M., Scheurich, P., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401036 · Cited by 257
Self-citationSanmamed, M. F., Carranza-Rua, O., Alfaro, C., Oñate, C., Martín‐Algarra, S., Pérez, G., Landazuri, S. F., González, Á., Groß, S., Rodríguez, I., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3203 · Cited by 256
The role of interleukin-8 in cancer cells and microenvironment interaction
Yuan, A. (2005) · Frontiers in bioscience · doi:10.2741/1579 · Cited by 253
Seppola, M., Larsen, A. N., Steiro, K., Robertsen, B., & Jensen, I. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.08.003 · Cited by 251
Kang, S., Cho, S., Chung, J. H., Hammerberg, C., Fisher, G. J., & Voorhees, J. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62479-0 · Cited by 251
Øvrevik, J., Refsnes, M., Låg, M., Holme, J. A., & Schwarze, P. E. (2015) · Biomolecules · doi:10.3390/biom5031399 · Cited by 246
Lead (Pb) Exposure Enhances Expression of Factors Associated with Inflammation
Metryka, E., Chibowska, K., Gutowska, I., Falkowska, A., Kupnicka, P., Barczak, K., Chlubek, D., & Baranowska-Bosiacka, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061813 · Cited by 217
Siwak, D. R., Shishodia, S., Aggarwal, B. B., & Kurzrock, R. (2005) · Cancer · doi:10.1002/cncr.21216 · Cited by 235
Macrolide antibiotics as immunomodulatory medications: Proposed mechanisms of action
Shinkai, M., Henke, M. O., & Rubin, B. K. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.11.001 · Cited by 229
Synergy in cytokine and chemokine networks amplifies the inflammatory response
Gouwy, M., Struyf, S., Proost, P., & Damme, J. V. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.03.005 · Cited by 224
Lahouassa, H., Moussay, E., Rainard, P., & Riollet, C. (2007) · Cytokine · doi:10.1016/j.cyto.2007.04.006 · Cited by 219
Leclercq, S., De Saeger, C., Delzenne, N., de Timary, P., & Stärkel, P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.003 · Cited by 216
Visciano, C., Liotti, F., Prevete, N., Calı̀, G., Franco, R., Collina, F., de Paulis, A., Marone, G., Santoro, M. M., & Melillo, R. M. (2015) · Oncogene · doi:10.1038/onc.2014.441 · Cited by 214
Walle, J. V. D., Hendrickx, A., Romier, B., Larondelle, Y., & Schneider, Y. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.04.002 · Cited by 196
Novel host response therapeutic approaches to treat periodontal diseases
Kirkwood, K. L., Cirelli, J. A., Rogers, J. E., & Giannobile, W. V. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00166.x · Cited by 218
Hypoxia Increases Resistance of Human Pancreatic Cancer Cells to Apoptosis Induced by Gemcitabine
Yokoi, K., & Fidler, I. J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0488 · Cited by 202
Trivedi, N. R., Gilliland, K. L., Zhao, W., Liu, W., & Thiboutot, D. M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700213 · Cited by 196
Drug-Induced Nephrotoxicity: Clinical Impact and Preclinicalin VitroModels
Tiong, H. Y., Huang, P., Xiong, S., Li, Y., Vathsala, A., & Zink, D. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400720w · Cited by 193
Pryor, M. J., Rawlinson, S. M., Butcher, R. E., Barton, C. L., Waterhouse, T. A., Vasudevan, S. G., Bardin, P. G., Wright, P. J., Jans, D. A., & Davidson, A. D. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00579.x · Cited by 191
Baranova, I. N., Kurlander, R. J., Bocharov, A. V., Vishnyakova, T. G., Chen, Z., Remaley, A. T., Csákó, G., Patterson, A. P., & Eggerman, T. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7147 · Cited by 189
Liver fibrosis and inflammation. A review
Stalnikowitz, D. K., & Weissbrod, A. B. (2003) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32127-1 · Cited by 183
Dong, L., Li, Z., Leffler, N. R., Asch, A. S., Chi, J., & Yang, L. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061991 · Cited by 183
Carroll, P. A., Brazeau, E., & Lagunoff, M. (2004) · Virology · doi:10.1016/j.virol.2004.07.008 · Cited by 181
Nutrient Modification of the Innate Immune Response
Schwartz, E. A., Zhang, W.-Y., Karnik, S. K., Borwege, S., Anand, V. R., Laine, P. S., Su, Y., & Reaven, P. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201681 · Cited by 180
Elmezayen, R., Gazzar, M. E., Seeds, M. C., McCall, C. E., Dreskin, S. C., & Nicolls, M. R. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.04.011 · Cited by 178
You, Y., Borgmann, K., Edara, V. V., Stacy, S., Ghorpade, A., & Ikezu, T. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1706801 · Cited by 176
Härtel, C., Strunk, T., Bucsky, P., & Schultz, C. (2004) · Cytokine · doi:10.1016/j.cyto.2004.02.004 · Cited by 175
Tumor Cell Apoptosis Polarizes Macrophages—Role of Sphingosine-1-Phosphate
Weigert, A., Tzieply, N., von Knethen, A., Johann, A. M., Schmidt, H., Geißlinger, G., & Brüne, B. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-12-1096 · Cited by 171
Adam, E., Hansen, K. K., Astudillo, O., Coulon, L., Bex, F., Duhant, X., Jaumotte, E., Hollenberg, M. D., & Jacquet, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507140200 · Cited by 166
Influence of apple polyphenols on inflammatory gene expression
Jung, M., Triebel, S., Anke, T., Richling, E., & Erkel, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800575 · Cited by 161
Saadane, A., Masters, S., DiDonato, J. A., Li, J., & Berger, M. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0323oc · Cited by 161
Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8
Walle, T., Kraske, J. A., Liao, B., Lenoir, B., Timke, C., Halbach, E. V. B. U., Tran, F., Griebel, P., Albrecht, D., Ahmed, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abh4050 · Cited by 159
Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements
Khabar, K. S. A. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0383-x · Cited by 157
El-Deeb, N., Yassin, A. M., Al-Madboly, L. A., & El-Hawiet, A. M. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0877-z · Cited by 144
Chan, S. M. H., Carey, A. L., Watt, M. J., & Febbraio, M. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00030.2004 · Cited by 158
Shinkai, M., Foster, G. H., & Rubin, B. K. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00093.2005 · Cited by 154
Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly
Qian, F., Wang, X., Zhang, L., Chen, S., Piecychna, M., Allore, H., Bockenstedt, L., Malawista, S., Bucala, R., Shaw, A. C., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2011.00759.x · Cited by 154
IL-1β-Specific Up-Regulation of Neutrophil Gelatinase-Associated Lipocalin Is Controlled by IκB-ζ
Cowland, J. B., Muta, T., & Borregaard, N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5559 · Cited by 151
Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages
Karimi, K., Sarir, H., Mortaz, E., Smit, J. J., Hosseini, H., de Kimpe, S. J., Nijkamp, F. P., & Folkerts, G. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-66 · Cited by 151
Grange, P., Raingeaud, J., Cálvez, V., & Dupin, N. (2009) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.08.001 · Cited by 149
Toussaint, E., Donner, D. B., & Roman, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207442 · Cited by 148
Karlsen, J. R., Borregaard, N., & Cowland, J. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017129 · Cited by 146
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer
Campbell, L. M., Maxwell, P. J., & Waugh, D. J. J. (2013) · Pharmaceuticals · doi:10.3390/ph6080929 · Cited by 145
Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfaces
Ratner, A. J., Lysenko, E. S., Paul, M. N., & Weiser, J. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500599102 · Cited by 144
Podechard, N., Lecureur, V., Ferrec, E. L., Guénon, I., Sparfel, L., Gilot, D., Gordon, J., Lagente, V., & Fardel, O. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.01.006 · Cited by 151
Winzen, R., Thakur, B. K., Dittrich‐Breiholz, O., Shah, M., Redich, N., Dhamija, S., Kracht, M., & Holtmann, H. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01493-07 · Cited by 140
Self-citationFung, T. S., Huang, M., & Liu, D. X. (2014) · Virus Research · doi:10.1016/j.virusres.2014.09.016 · Cited by 134
Sharma, R., Deacon, S. E., Nowak, D., George, S. E., Szymonik, M., Tang, A. A.-S., Tomlinson, D. C., Davies, A. G., McPherson, M. J., & Wälti, C. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.02.028 · Cited by 135
Saraiva, T. D. L., Gomes-Santos, A. C., Rocha, C. S., Moreira, T. G., Cruz, D. N., Lemos, L., SOUSA, A. L. S., Pereira, V. B., de Azevedo, M. S. P., de Moraes, K. M. C. M. T., et al. (2014) · Gut Pathogens · doi:10.1186/1757-4749-6-33 · Cited by 133
NF-κB signaling pathway in tumor microenvironment
Cao, Y., Yi, Y., Han, C., & Shi, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1476030 · Cited by 144
Dengue Virus Nonstructural Protein NS5 Induces Interleukin-8 Transcription and Secretion
Medin, C. L., Fitzgerald, K. A., & Rothman, A. L. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.11053-11061.2005 · Cited by 133
Brown, C. R., Blaho, V. A., & Loiacono, C. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.893 · Cited by 131
Lipolysis of triglyceride-rich lipoproteins, vascular inflammation, and atherosclerosis
Schwartz, E. A., & Reaven, P. D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.021 · Cited by 130
Viemann, D., Goebeler, M., Schmid, S., Klimmek, K., Sorg, C., Ludwig, S., & Roth, J. (2004) · Blood · doi:10.1182/blood-2003-09-3296 · Cited by 132
THIS ARTICLE HAS BEEN RETRACTED Exercise induces interleukin‐8 expression in human skeletal muscle
Akerstrom, T. C. A., Steensberg, A., Keller, P., Keller, C., Penkowa, M., & Pedersen, B. K. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.077610 · Cited by 130
RetractedXu, X., Zhang, H., Zhang, Q., Huang, Y., Dong, J., Liang, Y., Liu, H., & Tong, D. (2013) · Veterinary Microbiology · doi:10.1016/j.vetmic.2013.01.034 · Cited by 129
Scipione, C. A., Sayegh, S., Romagnuolo, R., Tsimikas, S., Marcovina, S. M., Boffa, M. B., & Koschinsky, M. L. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m060210 · Cited by 127
CXCL8 in Tumor Biology and Its Implications for Clinical Translation
Xiong, X., Liao, X., Qiu, S., Xu, H., Zhang, S., Wang, S., Ai, J., & Yang, L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.723846 · Cited by 124
N’Guessan, P. D., Riediger, F., Vardarova, K., Scharf, S., Eitel, J., Opitz, B., Slevogt, H., Weichert, W., Hocke, A. C., Schmeck, B., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.178319 · Cited by 125
YopJ targets TRAF proteins to inhibit TLR-mediated NF-?B, MAPK and IRF3 signal transduction
Sweet, C. R., Conlon, J. E., Golenbock, D. T., Goguen, J. D., & Silverman, N. S. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00990.x · Cited by 126
Piret, J., Jacques, D., Audinot, J., Mejia, J., Boilan, E., Noël, F., Fransolet, M., Demazy, C., Lucas, S., Saout, C., et al. (2012) · Nanoscale · doi:10.1039/c2nr31785k · Cited by 129
CURCUMIN AS AN INHIBITOR OF ANGIOGENESIS
Bhandarkar, S. S., & Arbiser, J. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_7 · Cited by 127
PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
Dalmasso, G., Charrier‐Hisamuddin, L., Nguyen, H. T. T., Yan, Y., Sitaraman, S. V., & Merlin, D. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.026 · Cited by 122
In vivo biological response to extracorporeal shockwave therapy in human tendinopathy
Waugh, C., Morrissey, D., Jones, E., Riley, G. P., Langberg, H., & Screen, H. (2015) · European Cells and Materials · doi:10.22203/ecm.v029a20 · Cited by 120
The NOD2-RICK Complex Signals from the Plasma Membrane
Lécine, P., Esmiol, S., tais, J.-Y. M., Nicoletti, C., Nourry, C., McDonald, C., Núñez, G., Hugot, J., Borg, J., & Ollendorff, V. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606242200 · Cited by 120
Metadata
- Authors
- Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Institute of Pharmacology, Medical School Hannover , Germany
- Corresponding author
- Kracht, Michael
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 72
- Issue
- 5
- Pages
- 847-855
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2149122802
- Cited by
- 1,058
- References
- 87
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 17 · 2023: 35 · 2022: 37 · 2021: 35 · 2020: 31 · 2019: 35 · 2018: 37 · 2017: 39 · 2016: 49 · 2015: 79 · 2014: 64 · 2013: 54 · 2012: 39
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-8, chemokines, gene expression regulation, transcriptional activation, NF-κB, JNK signaling, p38 MAPK, mRNA stabilization, inflammatory cytokines, chemokine induction, leukocyte recruitment
- MeSH terms
- Animals, Base Sequence, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Repressor Proteins, Transcription Factors, Transcription, Genetic, Signal Transduction, Transcriptional Activation, Interleukin-8, NF-kappa B, RNA Stability, Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review