Prediction of outcome of physiotherapy in advanced Parkinson's disease
Abstract
OBJECTIVE: Prediction of the effect of a home physiotherapy intervention on the basis of four clinical characteristics of patients with advanced Parkinson's disease. DESIGN: A repeated measures design comparing six weeks without treatment with six weeks of physiotherapy and a follow-up of 12 weeks. SUBJECTS: Persons with Parkinson's disease without dementia and suffering from considerable functional disability. INTERVENTION: Community physiotherapists treated patients in the home situation three times a week teaching cueing and conscious movement control for walking and carrying out transfers in and out of beds and chairs. MAIN OUTCOME MEASURES: Mental status, disease severity, age and mood were included as predictor variables. A new functional scale developed as part of a previous study was used as the dependent variable administered in both the hospital and the home to determine whether the outcome generalized from the learning to a different environment. RESULTS: Only disease severity was a negative predictor of treatment outcome at home. In the hospital setting none of the factors predicted the immediate effect of treatment but cognitive ability and age were determinants of whether the treatment effects were maintained in the long term. CONCLUSIONS: Using cueing and cognitive strategies benefited younger and older patients with Parkinson's disease alike. However, the findings indicate targeting of treatment at patients with milder disease severity and providing follow-up treatment for older and cognitively less able patients.
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Retention of task benefits after a period without training is consistent with motor learning and underlying neuroplasticity.
“The fact that individuals with PD show retention of task benefits (especially gait and balance) after a period of time without training is consistent with motor learning and underlying neuroplasticity 38.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [38]
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Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
- Authors
- Nieuwboer, A., De Weerdt, W., Dom, R., & Bogaerts, K.
- Affiliations
- KU Leuven (BE)
- Department of Rehabilitation Sciences, Faculty of Physical Education and Physiotherapy, Katholieke Universiteit Leuven, Belgium
- Venue
- Clinical Rehabilitation
- Publisher
- SAGE Publications
- Published
- 2002-12
- Volume
- 16
- Issue
- 8
- Pages
- 886-893
- ISSN
- 0269-2155 (ISSN-L)
- 1477-0873
- OpenAlex
- W2108482425
- Cited by
- 34
- References
- 24
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- Parkinson's disease, home-based physiotherapy, treatment outcome prediction, cueing strategies, functional disability, disease severity, cognitive ability, age, transfer of learning, functional scales, walking
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Cognition, Female, Forecasting, Persons with Disabilities, Humans, Male, Middle Aged, Parkinson Disease, Prognosis, Severity of Illness Index, Treatment Outcome, Physical Therapy Modalities
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