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Evaluating the cytotoxicity of ionic liquids using human cell line HeLa
Abstract
This paper presents cytotoxicity data of selected imidazolium ionic liquids evaluated in vitro on the human tumor cell line HeLa. It was found that for 1-n-butyl-3-methylimidazolium entities the toxicity depends strongly on the associated anion; EC 50 values are lowest for tetrafluoroborate. No direct dependence of the reduced effect concentration was found on elongating the short, methyl chain to ethyl or n-hexyl. Only for the ionic liquid with an n-decyl chain, the longest one studied, did higher hydrophobicity result in a EC 50 one order of magnitude lower than that obtained with the n-butyl entity. The effect concentrations of imidazolium ionic liquids in the HeLa system used are lower than the values obtained for conventional organic solvents such as dichloromethane, toluene or xylene.
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Cited by
Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine
Egorova, K. S., Gordeev, E. G., & Ananikov, V. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00562 · Cited by 1,649
Environmental impacts, pollution sources and pathways of spent lithium-ion batteries
Mrozik, W., Rajaeifar, M. A., Heidrich, O., & Christensen, P. (2021) · Energy & Environmental Science · doi:10.1039/d1ee00691f · Cited by 1,028
Evaluation of toxicity and biodegradability of choline chloride based deep eutectic solvents
Radošević, K., Cvjetko Bubalo, M., Gaurina Srček, V., Grgas, D., Landeka Dragičević, T., & Radojčić Redovniković, I. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2014.09.034 · Cited by 770
Applications of Ionic Liquids in Carbohydrate Chemistry: A Window of Opportunities
El Seoud, O. A., Koschella, A., Fidale, L. C., Dorn, S., & Heinze, T. (2007) · Biomacromolecules · doi:10.1021/bm070062i · Cited by 668
INNOVATIVE APPLICATIONS OF IONIC LIQUIDS AS “GREEN” ENGINEERING LIQUIDS
Zhao, H. (2006) · Chemical Engineering Communications · doi:10.1080/00986440600586537 · Cited by 343
Metadata
- Authors
- Stepnowski, P., Skladanowski, A. C., Ludwiczak, A., & Laczyńska, E.
- Venue
- Human & Experimental Toxicology
- Publisher
- SAGE Publications
- Published
- 2004-11
- Volume
- 23
- Issue
- 11
- Pages
- 513-517
- ISSN
- 0960-3271 (ISSN-L)
- 1477-0903
- OpenAlex
- W2023583381
- Cited by
- 246
- References
- 0
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stepnowski, P., Skladanowski, A. C., Ludwiczak, A., & Laczyńska, E. (2004). Evaluating the cytotoxicity of ionic liquids using human cell line HeLa. Human & Experimental Toxicology. https://doi.org/10.1191/0960327104ht480oa
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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