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Cited by 448

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Clomipramine and Exposure for Obsessive-Compulsive Rituals: 1

Marks, I. M., Stern, R. S., Mawson, D., Cobb, J., McDonald, R.·1980·British Journal of Psychiatry

Abstract

Summary: Forty chronic obsessive-compulsive ritualizers were randomly assigned to treatment with oral clomipramine or placebo for 8 months. During weeks 4 to 7 these two groups were each randomly split into treatment by relaxation or by exposure in vivo, and during weeks 7 to 10 all patients had exposure in vivo. Double blind assessments were made at weeks 4, 7, 10, 18, 36, 62 and 114. Results are reported to one year. Clomipramine produced significant improvement in rituals, mood and social adjustment, but only in those patients who initially had depressed mood. The clomipramine effect was maximum from weeks 10 to 18 and diminished thereafter. On stopping clomipramine patients often relapsed and improved again on restarting the drug. Relaxation produced little change. Exposure produced significant lasting improvement in rituals, but less change in mood; improvement generalized to social adjustment at follow-up. Clomipramine plus exposure had a slight additive but not interactional effect. Clomipramine enhanced compliance both with exposure and with relaxation. Clomipramine is useful for compulsive ritualizers with depressed mood, but may need continuation for over a year and combination with exposure in vivo. Exposure in vivo remains the treatment of choice for rituals without depressed mood.

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Metadata

Authors
Marks, I. M., Stern, R. S., Mawson, D., Cobb, J., & McDonald, R.
Venue
British Journal of Psychiatry
Published
1980-01
Volume
136
Issue
1
Pages
1-25
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2097231409
Cited by
448
References
38
FWCI
27.42
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Clomipramine and Exposure for Obsessive-Compulsive Rituals: 1. https://app.cochat.ai/papers/10.1192/bjp.136.1.1
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Marks, I. M., Stern, R. S., Mawson, D., Cobb, J., & McDonald, R. (1980). Clomipramine and Exposure for Obsessive-Compulsive Rituals: 1. British Journal of Psychiatry. https://doi.org/10.1192/bjp.136.1.1

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