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Decreased Imipramine Binding in the Brains of Patients with Depressive Illness
Open accessAbstract
Summary: The binding of tritiated imipramine was significantly reduced in the hippocampus and occipital cortex from a series of patients with depressive illness compared with age-matched patients with no psychiatric disorder. In contrast there was no change in imipramine binding in established cases of senile dementia of Alzheimer-type. Scatchard analysis indicated normal binding affinity but a reduction in the number of imipramine binding sites in depression. These observations parallel previous findings of decreased binding sites in platelets from depressed patients and suggest there may be an abnormality in the uptake mechanism for serotonin in depression.
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Cited by
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Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221
Neuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180
Mann, J. J., Huang, Y.-Y., Underwood, M. D., Kassir, S. A., Oppenheim, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.729 · Cited by 613
The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system
Mann, J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00228-1 · Cited by 394
Metadata
- Authors
- Perry, E. K., Marshall, E. F., Blessed, G., Tomlinson, B. E., & Perry, R. H.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1983-02
- Volume
- 142
- Issue
- 2
- Pages
- 188-192
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2062186695
- Cited by
- 261
- References
- 0
- FWCI
- 23.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Decreased Imipramine Binding in the Brains of Patients with Depressive Illness. https://app.cochat.ai/papers/10.1192/bjp.142.2.188
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- Perry, E. K., Marshall, E. F., Blessed, G., Tomlinson, B. E., & Perry, R. H. (1983). Decreased Imipramine Binding in the Brains of Patients with Depressive Illness. British Journal of Psychiatry. https://doi.org/10.1192/bjp.142.2.188
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
