The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cerebral Blood Flow in Chronic Cocaine Users: A Study with Positron Emission Tomography
Abstract
Occurrence of cerebrovascular accidents has been associated with cocaine abuse. We investigated the relative distribution of cerebral blood flow (CBF) in groups of chronic cocaine users, and of normal controls. Relative CBF was measured using positron emission tomography and 15 oxygen-labelled water. The cocaine users showed areas of deranged CBF as evidenced by patchy regions of defective isotope accumulation throughout their brain. The chronic cocaine users showed decreased relative CBF in the prefrontal cortex when compared with normal subjects. The repeated scans of some cocaine users, after 10 days of cocaine withdrawal, continued to show decreased relative CBF of the prefrontal cortex. We hypothesise that some of the widespread defects in CBF in the cocaine users could reflect the effects of vasospasm in cerebral arteries exposed chronically to the sympathomimetic actions of cocaine.
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Cites
The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence
(1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.11.1259 · Cited by 2,538 · cited 1×
“Indeed, it has been suggested that, in some cases, thepatientmay takecocaineasself-medicationfor an underlying depression (Khantzian, 1985).”
BackgroundCocaine: plasma concentrations after intranasal application in man.
Van Dyke, C., Barash, P. G., Jatlow, P., & Byck, R. (1976) · Science · doi:10.1126/science.56036 · Cited by 224
Cited by
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667
Self-citationJentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513
Rogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924
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Metadata
- Authors
- Volkow, N. D., Mullani, N., Gould, K. L., Adler, S., & Krajewski, K.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1988-05
- Volume
- 152
- Issue
- 5
- Pages
- 641-648
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2147144711
- Cited by
- 365
- References
- 2
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Volkow, N. D., Mullani, N., Gould, K. L., Adler, S., & Krajewski, K. (1988). Cerebral Blood Flow in Chronic Cocaine Users: A Study with Positron Emission Tomography. British Journal of Psychiatry. https://doi.org/10.1192/bjp.152.5.641
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