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Drug Treatment of Panic Disorder: Comparative Efficacy of Alprazolam, Imipramine, and Placebo: Cross-National Collaborative Panic Study, Second Phase Investigators
Abstract
The Cross-National Collaborative Panic Study, Phase Two, compared alprazolam with imipramine and with placebo in a sample of 1168 randomly assigned subjects. The study, conducted at 12 centres, assessed clinical change over eight weeks of double-blind drug treatment. Improvement occurred with alprazolam by week 1 and 2, and with imipramine by week 4. By the end of week 8, however, the effects of the two active drugs were similar to each other, and both were superior to placebo for most outcome measures.
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Citations
Cites
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Ballenger, J. C. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800290027004 · Cited by 564
Respiratory control as a treatment for panic attacks
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Withdrawal Reaction after Long-Term Therapeutic Use of Benzodiazepines
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Tyrer, P. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91340-6 · Cited by 132
Overview of the Cross-National Collaborative Panic Study: I. Efficacy in Short-term Treatment
Klerman, G. L. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800290021003 · Cited by 104
Self-citation
Cited by
Katzman, M. A., Bleau, P., Blier, P., Chokka, P., Kjernisted, K., Van Ameringen, M., & the Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-s1-s1 · Cited by 1,090
Bandelow, B., Zohar, J., Hollander, E., Kasper, S., Möller, H.-J., WFSBP TASK FORCE ON TREATMENT GUIDE, Bandelow, B., Zohar, J., Hollander, E., Kasper, S., et al. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970802465807 · Cited by 854
Clark, D. M., Salkovskis, P. M., Hackmann, A., Middleton, H., Anastasiades, P., & Gelder, M. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.164.6.759 · Cited by 673
Marks, I. M., Swinson, R. P., Başoǧlu, M., Kuch, K., Noshirvani, H., O'Sullivan, G., Lelliott, P. T., Kirby, M., McNamee, G., Sengun, S., et al. (1993) · British Journal of Psychiatry · doi:10.1192/bjp.162.6.776 · Cited by 478
Use of benzodiazepines in anxiety disorders
Wood, A. J. J., Shader, R. I., & Greenblatt, D. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305133281907 · Cited by 341
Metadata
- Authors
- Klerman, G. L.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1992-02
- Volume
- 160
- Issue
- 2
- Pages
- 191-202
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2781790481
- Cited by
- 229
- References
- 7
- FWCI
- 28.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Drug Treatment of Panic Disorder: Comparative Efficacy of Alprazolam, Imipramine, and Placebo: Cross-National Collaborative Panic Study, Second Phase Investigators. https://app.cochat.ai/papers/10.1192/bjp.160.2.191
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- Klerman, G. L. (1992). Drug Treatment of Panic Disorder: Comparative Efficacy of Alprazolam, Imipramine, and Placebo: Cross-National Collaborative Panic Study, Second Phase Investigators. British Journal of Psychiatry. https://doi.org/10.1192/bjp.160.2.191
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.