Alprazolam in the treatment of generalized anxiety and panic disorders: A double-blind placebo-controlled study
Abstract
In a double-blind controlled study lasting 8 weeks, 50 anxious psychoneurotic outpatients with a primary diagnosis of generalized anxiety or panic disorder were randomly assigned to alprazolam (n=30), a new benzodiazepine, or placebo (n=20), after a washout period of 1 week. Alprazolam at dosages between 0.25 and 3 mg/day was found to be significantly better than placebo in the treatment of either disorder. The finding that alprazolam was effective in the treatment of panic disorder is of interest as this diagnostic category is usually treated with tricyclic antidepressants or MAO inhibitors.
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The prevalence of rebound insomnia is significantly lower in all benzodiazepines compared to triazolam.
“The prevalence of rebound insomnia was found to be significantly lower in all benzodiazepines compared to triazolam [52, 60-69] and was lower than that with triazolam.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [64]
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Gelder, M. (1989) · Psychological Medicine · doi:10.1017/s0033291700012319 · Cited by 38 · see citing works
UHLENHUTH, E. H., Alexander, P. E., Dempsey, G. M., Jones, W. R., Coleman, B. S., & Swiontek, A. M. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00125-0 · Cited by 37 · see citing works
A Guide to Benzodiazepine Selection. Part II: Clinical Aspects
Teboul, E., & Chouinard, G. (1991) · The Canadian Journal of Psychiatry · doi:10.1177/070674379103600117 · Cited by 25 · see citing works
Self-citationLong-term drug treatment of panic disorder
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- Authors
- Chouinard, G., Annable, L., Fontaine, R., & Solyom, L.
- Affiliations
- Royal Victoria Hospital (CA)
- McGill University (CA)
- Venue
- Psychopharmacology
- Published
- 1982-07
- Volume
- 77
- Issue
- 3
- Pages
- 229-233
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2069644518
- Cited by
- 256
- References
- 16
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2016: 4 · 2015: 2 · 2013: 4 · 2012: 3
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- alprazolam, generalized anxiety disorder, panic disorder, benzodiazepines, neurosis, anxiety treatment, placebo comparison
- MeSH terms
- Adult, Alprazolam, Anxiety, Benzodiazepines, Clinical Trials as Topic, Double-Blind Method, Fear, Female, Humans, Male, Middle Aged, Panic, Placebos, Psychiatric Status Rating Scales, Anti-Anxiety Agents
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