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The Effect of Clozapine on Cognition and Psychiatric Symptoms in Patients with Schizophrenia
Abstract
Psychiatric symptoms and cognition were assessed in 13 patients with schizophrenia, one patient with schizoaffective disorder, and one patient with psychosis not otherwise specified while they received a conventional neuroleptic and again after an average of 15 months on clozapine. Despite improvements in psychiatric symptoms, attention, memory, and higher-level problem-solving were essentially unchanged. This suggests that certain cognitive deficits are relatively independent of psychotic symptoms in schizophrenia, and are probably central and enduring features of the disorder. Cognitive disability appeared to have been rate-limiting in the sample's rehabilitation, as patients' social and vocational adjustment remained marginal during the study. We also observed that treatment with clozapine was associated with a decline in some memory functions; the potent anticholinergic properties of the drug may have been responsible for this.
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Cites
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Breier, A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810270051007 · Cited by 626
Cited by
The Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia
Meltzer, H. Y., & McGurk, S. R. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033376 · Cited by 1,020
Nonsocial and social cognition in schizophrenia: current evidence and future directions
Green, M. F., Horan, W. P., & Lee, J. (2019) · World Psychiatry · doi:10.1002/wps.20624 · Cited by 612
Stability and Course of Neuropsychological Deficits in Schizophrenia
Heaton, R. K., Gladsjo, J. A., Palmer, B. W., Kuck, J., Marcotte, T. D., & Jeste, D. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.24 · Cited by 618
Prefrontal Serotonin Depletion Affects Reversal Learning But Not Attentional Set Shifting
Clarke, H. F., Walker, S. C., Crofts, H. S., Dalley, J. W., Robbins, T. W., & Roberts, A. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3690-04.2005 · Cited by 358
Sams-Dodd, F., Lipska, B. K., & Weinberger, D. R. (1997) · Psychopharmacology · doi:10.1007/s002130050349 · Cited by 346
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Metadata
- Authors
- Goldberg, T. E., Greenberg, R. D., Griffin, S. J., Gold, J. M., Kleinman, J. E., Pickar, D., Schulz, S. C., & Weinberger, D. R.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1993-01
- Volume
- 162
- Issue
- 1
- Pages
- 43-48
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2117512667
- Cited by
- 289
- References
- 2
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Effect of Clozapine on Cognition and Psychiatric Symptoms in Patients with Schizophrenia. https://app.cochat.ai/papers/10.1192/bjp.162.1.43
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- Goldberg, T. E., Greenberg, R. D., Griffin, S. J., Gold, J. M., Kleinman, J. E., Pickar, D., Schulz, S. C., & Weinberger, D. R. (1993). The Effect of Clozapine on Cognition and Psychiatric Symptoms in Patients with Schizophrenia. British Journal of Psychiatry. https://doi.org/10.1192/bjp.162.1.43
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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