The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA (‘ecstasy’) users
Abstract
Background: The use of MDMA (‘ecstasy’) is common among young people in Western countries. Animal models of MDMA toxicity suggest a loss of serotonergic neurons, and potentially implicate it in the development of significant psychiatric morbidity in humans. Aims: To test whether long-term use of MDMA can produce abnormalities in cerebral serotonin, but not dopamine, transporter binding measured by single photon emission computed tomography (SPECT) Method: Ten male regular ecstasy users and 10 well-matched controls recruited from the same community sources participated in SPECT with the serotonin transporter (SEPT) ligand [123 I]-CIT. Dopamine transporter binding was determined from scans acquired 23 hours after injection of the tracer. Results: Ecstasy users showed a cortical reduction of SERT binding, particularly prominent in primary sensory-motor cortex, with normal dopamine transporter binding in lenticular nuclei. Conclusions: This cross-sectional association study provides suggestive evidence for specific, at least temporary, serotonergic neurotoxicity of MDMA in humans.
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Cites
Ricaurte, G. A., DeLanney, L. E., Irwin, I., & Langston, J. W. (1988) · Brain Research · doi:10.1016/0006-8993(88)91309-1 · Cited by 245
Cited by
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
Green, A. R., Mechan, A. O., Elliott, J. M., O’Shea, E., & Colado, M. I. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.3 · Cited by 1,272
Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research
Parrott, A. C. (2001) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.351 · Cited by 344
Brain Serotonin Transporter Density and Aggression in Abstinent Methamphetamine Abusers
Sekine, Y., Ouchi, Y., Takei, N., Yoshikawa, E., Nakamura, K., Futatsubashi, M., Okada, H., Minabe, Y., Suzuki, K., Iwata, Y., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.90 · Cited by 287
Neurotoxicity of substituted amphetamines: Molecular and cellular mechanisms
Cadet, J. L., Krasnova, I. N., Jayanthi, S., & Lyles, J. (2007) · Neurotoxicity Research · doi:10.1007/bf03033567 · Cited by 272
Reward-Related Decision-Making Deficits and Elevated Impulsivity Among MDMA and Other Drug Users
Hanson, K. L., Luciana, M., & Sullwold, K. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.02.003 · Cited by 125
Metadata
- Authors
- Semple, D. M., Ebmeier, K. P., Glabus, M. F., O'Carroll, R. E., & Johnstone, E. C.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1999-07
- Volume
- 175
- Issue
- 1
- Pages
- 63-69
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2036111662
- Cited by
- 280
- References
- 1
- FWCI
- 23.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA (‘ecstasy’) users. https://app.cochat.ai/papers/10.1192/bjp.175.1.63
- The paper
- Semple, D. M., Ebmeier, K. P., Glabus, M. F., O'Carroll, R. E., & Johnstone, E. C. (1999). Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA (‘ecstasy’) users. British Journal of Psychiatry. https://doi.org/10.1192/bjp.175.1.63
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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