The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Active monitoring of 12760 clozapine recipients in the UK and Ireland: Beyond pharmacovigilance
Abstract
Background: People prescribed clozapine for treatment-resistant schizophrenia have mandatory haematological monitoring through a case register for identifying reversible neutropenia. Aims: To quantify risk factors for agranulocytosis in subjects receiving clozapine. Method: Data from 12 760 subjects registered to receive clozapine from January 1990 to April 1997 were analysed. Risk factors for agranulocytosis were quantified using a Cox proportional-hazards regression analysis. Results: The risk for agranulocytosis in Asian subjects was 2.4 times that in Caucasians (P=0.03). There was an age-related increase in risk of 53% per decade (P=0.0001). Conclusions: The case register yielded valuable information for guiding research into the causes of the haematological reactions.
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Cites
Clozapine-induced agranulocytosis. incidence and risk factors in the united states
Alvir, J. M. J., Lieberman, J. A., Safferman, A. Z., Schwimmer, J. L., & Schaaf, J. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307153290303 · Cited by 967
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Stroup, T. S., & Gray, N. (2018) · World Psychiatry · doi:10.1002/wps.20567 · Cited by 572
Vermeulen, J. M., van Rooijen, G., van de Kerkhof, M. P. J., Sutterland, A. L., Correll, C. U., & de Haan, L. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sby052 · Cited by 246
Haematological toxicity of drugs used in psychiatry
Flanagan, R. J., & Dunk, L. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.917 · Cited by 236
Suicide in a large population of former psychiatric inpatients
Sani, G., Tondo, L., Koukopoulos, A., Reginaldi, D., Kotzalidis, G. D., Koukopoulos, A. E., Manfredi, G., Mazzarini, L., Pacchiarotti, I., Simonetti, A., et al. (2011) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2011.02205.x · Cited by 119
Metadata
- Authors
- Munro, J., O'Sullivan, D., Andrews, C., Arana, A., Mortimer, A., & Kerwin, R.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1999-12
- Volume
- 175
- Issue
- 6
- Pages
- 576-580
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2060442024
- Cited by
- 285
- References
- 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Active monitoring of 12760 clozapine recipients in the UK and Ireland: Beyond pharmacovigilance. https://app.cochat.ai/papers/10.1192/bjp.175.6.576
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- Munro, J., O'Sullivan, D., Andrews, C., Arana, A., Mortimer, A., & Kerwin, R. (1999). Active monitoring of 12760 clozapine recipients in the UK and Ireland: Beyond pharmacovigilance. British Journal of Psychiatry. https://doi.org/10.1192/bjp.175.6.576
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
