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Cited by 538

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: A meta-analysis

Open access
Smith, David, Dempster, Carrie, Glanville, Julie, Freemantle, Nick, Anderson, Ian·2002·British Journal of Psychiatry

Abstract

Background: In individual studies and limited meta-analyses venlafaxine has been reported to be more effective than comparator antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs). Aims: To perform a systematic review of all such studies. Method: We conducted a systematic review of double-blind, randomised trials comparing venlafaxine with alternative antidepressants in the treatment of depression. The primary outcome was the difference in final depression rating scale value, expressed as a standardised effect size. Secondary outcomes were response rate, remission rate and tolerability. Results: A total of 32 randomised trials were included. Venlafaxine was more effective than other antidepressants (standardised effect size was −0.14, 95% Cl −0.07 to −0.22). A similar significant advantage was found against SSRIs (20 studies) but nottricyclic antidepressants (7 studies). Conclusions: Venlafaxine has greater efficacy than SSRIs although there is uncertainty in comparison with other antidepressants. Further studies are required to determine the clinical importance of this finding.

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Metadata

Authors
Smith, D., Dempster, C., Glanville, J., Freemantle, N., & Anderson, I.
Venue
British Journal of Psychiatry
Published
2002-05
Volume
180
Issue
5
Pages
396-404
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2141398558
Cited by
538
References
49
FWCI
2.44
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: A meta-analysis. https://app.cochat.ai/papers/10.1192/bjp.180.5.396
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Smith, D., Dempster, C., Glanville, J., Freemantle, N., & Anderson, I. (2002). Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: A meta-analysis. British Journal of Psychiatry. https://doi.org/10.1192/bjp.180.5.396

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