Set-shifting-related basal ganglia deformation as a novel familial marker of obsessive–compulsive disorder
Open accessAbstract
The symptoms of obsessive–compulsive disorder (OCD) are suggestive of cognitive rigidity, and previous work identified impaired flexible responding on set-shifting tasks in such patients. The basal ganglia are central to habit learning and are thought to be abnormal in OCD, contributing to inflexible, rigid habitual patterns of behaviour. Here, we demonstrate that increased cognitive inflexibility, indexed by poor performance on the set-shifting task, correlated with putamen morphology, and that patients and their asymptomatic relatives had common curvature abnormalities within this same structure. The association between the structure of the putamen and the extradimensional errors was found to be significantly familial in OCD proband–relative pairs. The data implicate changes in basal ganglia structure linked to cognitive inflexibility as a familial marker of OCD. This may reflect a predisposing heightened propensity toward habitual response patterns and deficits in goal-directed planning.
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Cognitive inflexibility in OCD is linked to aberrant processing in frontostriatal circuits, including dorsolateral and ventrolateral prefrontal and striatal areas.
“Cognitive inflexibility in OCD is linked to aberrant processing in frontostriatal circuits, including dorsolateral and ventrolateral prefrontal and striatal areas”
From Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction (2023) · cites this paper as Isobe et al., 2021
The Discussion links ED-shifting errors in OCD to reduced connectivity between the dorsal striatum and frontal cortical regions, and the Results link shifting errors to putamen and pallidum morphology. Our copy does not identify dorsolateral or ventrolateral prefrontal areas, so it supports the general frontostriatal link but not those specific regions. Page numbers were not available in the indexed passages. (LLM, conf=0.85)
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Cites
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Cognitive inflexibility in OCD and related disorders
Chamberlain, S. R., Solly, J. E., Hook, R. W., Vaghi, M. M., & Robbins, T. W. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2020_198 · Cited by 82 · see citing works
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Research works printed but not linked: 11
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Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction
Jalal, B., Chamberlain, S. R., & Sahakian, B. J. (2023) · Brain and Behavior · doi:10.1002/brb3.3000 · Cited by 111 · see citing works
Self-citationCognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment
Frota Lisboa Pereira de Souza, A. M., Pellegrini, L., & Fineberg, N. A. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104073 · Cited by 8 · see citing works
Self-citation
- Authors
- Isobe, M., Vaghi, M., Fineberg, N. A., Apergis-Schoute, A. M., Bullmore, E. T., Sahakian, B. J., Robbins, T. W., & Chamberlain, S. R.
- Affiliations
- Kyoto University (JP)
- University of Cambridge (GB)
- University of Hertfordshire (GB)
- University of Leicester (GB)
- Corresponding author
- Chamberlain, Samuel R.
- ORCID
- Venue
- The British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2021-04-22
- Volume
- 220
- Issue
- 6
- Pages
- 314-317
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC7613037
- OpenAlex
- W3158048796
- Cited by
- 11
- References
- 3
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BIROn (Birkbeck, University of London) (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion)
- Apollo
- Funders
- GlaxoSmithKline
- Wellcome Trust (110,049/Z/15/Z, 110049/Z/15/Z and 110049/Z/15/A, 104631/Z/14/Z, 110,049/Z/15/A, /Z/15/Z, 110049, 104631)
- National Institute for Health and Care Research (NF-SI-0513-10051, NIHR200256)
- University of Hertfordshire
- Ministry of Education, Culture, Sports, Science and Technology (16K21720, 110049)
- European College of Neuropsychopharmacology
- H. Lundbeck A/S
- Medical Research Council (MC_G0802534)
- Japan Society for the Promotion of Science (16K21720)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- obsessive-compulsive disorder, set-shifting, cognitive inflexibility, basal ganglia, asymptomatic relatives, habit learning, goal-oriented planning, brain deformation
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