Distinct subcortical volume alterations in pediatric and adult OCD: a worldwide meta- and mega-analysis
Open accessAbstract
OBJECTIVE: Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. METHOD: images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. RESULTS: The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. CONCLUSIONS: The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A worldwide meta-analysis of 1830 OCD patients and 1759 control subjects found smaller hippocampal volumes in patients.
“Consistent with this expanded orbitofrontal striatal model, a worldwide meta‐analysis of 1830 OCD patients and 1759 control subjects found smaller hippocampal volumes in patients (Boedhoe et al., 2017; such hippocampal volume might help explain visuospatial deficits in OCD discussed below).”
From Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction (2023) · cites this paper as Boedhoe et al., 2017
The Methods (Abstract) give the stated worldwide sample of 1,830 OCD patients and 1,759 controls. The Meta-analysis results report significantly smaller hippocampal volume in adults (1,495 patients and 1,472 controls), but no significant subcortical-volume difference in the pediatric comparison. The claim leaves out that the hippocampal finding was specific to the adult analysis. (LLM, conf=0.87)
Experimental — accuracy not yet measuredInterference control and motor response inhibition are both dependent on cortico-striato-thalamo-cortical (CSTC) circuits.
“The interference control and motor response inhibition are both dependent on cortico–striato–thalamo–cortical (CSTC) circuits [for review, see (3, 20)] intensively studied in OCD (21–24).”
From Functional connectivity changes in obsessive-compulsive disorder correspond to interference control and obsessions severity (2020) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610 · see citing works
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
GPOWER: A general power analysis program
Erdfelder, E., Faul, F., & Buchner, A. (1996) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03203630 · Cited by 4,864 · see citing works
The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication
Ruscio, A. M., Stein, D. J., Chiu, W. T., & Kessler, R. C. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.94 · Cited by 2,771 · see citing works
Self-citationChildren's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity
SCAHILL, L., RIDDLE, M. A., McSWIGGIN-HARDIN, M., ORT, S. I., KING, R. A., GOODMAN, W. K., CICCHETTI, D., & LECKMAN, J. F. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199706000-00023 · Cited by 2,045 · see citing works
Size and burden of mental disorders in Europe—a critical review and appraisal of 27 studies
Wittchen, H.-U., & Jacobi, F. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.04.012 · Cited by 1,503 · cited 1× · see citing works
“Obsessive-compulsive disorder (OCD) is a neurodevelopmental disorder that affects 1%–3% of the population (1, 2).”
Menzies, L., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., & Bullmore, E. T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.09.005 · Cited by 1,190 · see citing works
for the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.69 · Cited by 1,172 · see citing works
Self-citationfor the ENIGMA Schizophrenia Working Group, van Erp, T. G. M., Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.63 · Cited by 1,140 · see citing works
Self-citationVoxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder
Radua, J., & Mataix-Cols, D. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.055046 · Cited by 863 · see citing works
Self-citationObsessive-compulsive disorder: beyond segregated cortico-striatal pathways
Milad, M. R., & Rauch, S. L. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.003 · Cited by 847 · see citing works
A Family Study of Obsessive-compulsive Disorder
Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O. J., Liang, K.-Y., LaBuda, M., Walkup, J., Grados, M., & Hoehn-Saric, R. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.358 · Cited by 657 · see citing works
Morey, R. A., Petty, C. M., Xu, Y., Pannu Hayes, J., Wagner, H. R., Lewis, D. V., LaBar, K. S., Styner, M., & McCarthy, G. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.033 · Cited by 540 · see citing works
Stewart, S. E., Geller, D. A., Jenike, M., Pauls, D., Shaw, D., Mullin, B., & Faraone, S. V. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00302.x · Cited by 481 · see citing works
Mapping structural brain alterations in obsessive-compulsive disorder
Pujol, J., Soriano-Mas, C., Alonso, P., Cardoner, N., Menchón, J. M., Deus, J., & Vallejo, J. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.720 · Cited by 429 · see citing works
Self-citationRadua, J., van den Heuvel, O. A., Surguladze, S., & Mataix-Cols, D. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.70 · Cited by 400 · see citing works
Self-citationBrain circuitry of compulsivity
van den Heuvel, O. A., van Wingen, G., Soriano-Mas, C., Alonso, P., Chamberlain, S. R., Nakamae, T., Denys, D., Goudriaan, A. E., & Veltman, D. J. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.005 · Cited by 374 · see citing works
Self-citationGronenschild, E. H. B. M., Habets, P., Jacobs, H. I. L., Mengelers, R., Rozendaal, N., van Os, J., & Marcelis, M. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038234 · Cited by 365 · see citing works
Meta-analysis of brain volume changes in obsessive-compulsive disorder
Rotge, J.-Y., Guehl, D., Dilharreguy, B., Tignol, J., Bioulac, B., Allard, M., Burbaud, P., & Aouizerate, B. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.019 · Cited by 284 · see citing works
de Wit, S. J., Alonso, P., Schweren, L., Mataix-Cols, D., Lochner, C., Menchón, J. M., Stein, D. J., Fouche, J.-P., Soriano-Mas, C., Sato, J. R., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13040574 · Cited by 278 · see citing works
Self-citationGilbert, A. R., Moore, G. J., Keshavan, M. S., Paulson, L. A. D., Narula, V., Mac Master, F. P., Stewart, C. M., & Rosenberg, D. R. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.5.449 · Cited by 266 · see citing works
Rotge, J.-Y., Langbour, N., Guehl, D., Bioulac, B., Jaafari, N., Allard, M., Aouizerate, B., & Burbaud, P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.175 · Cited by 228 · see citing works
Kassem, M. S., Lagopoulos, J., Stait‐Gardner, T., Price, W. S., Chohan, T. W., Arnold, J. C., Hatton, S. N., & Bennett, M. R. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8365-7 · Cited by 212 · see citing works
Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E. A., Tiemeier, H. W., Albert Hofman, D., Niessen, W. J., et al. (2015) · QUT ePrints (Queensland University of Technology) · Cited by 207 · see citing works
Self-citationENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
Thompson, P. M., Andreassen, O. A., Vásquez, A. A., Bearden, C. E., Boedhoe, P. S. W., Brouwer, R. M., Buckner, R. L., Buitelaar, J. K., Bulayeva, K., Cannon, D. M., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.057 · Cited by 181 · see citing works
Self-citationMorphological Abnormalities of the Thalamus in Youths With Attention Deficit Hyperactivity Disorder
Ivanov, I., Bansal, R., Hao, X., Zhu, H., Kellendonk, C., Miller, L., Sanchez-Pena, J., Miller, A. M., Chakravarty, M. M., Klahr, K., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030398 · Cited by 172 · see citing works
Zarei, M., Mataix-Cols, D., Heyman, I., Hough, M., Doherty, J., Burge, L., Winmill, L., Nijhawan, S., Matthews, P. M., & James, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.032 · Cited by 160 · see citing works
Self-citationSchoemaker, D., Buß, C., Head, K., Sandman, C. A., Davis, E. P., Chakravarty, M. M., Gauthier, S. G., & Pruessner, J. C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.01.038 · Cited by 152 · see citing works
Volumetric MRI study of key brain regions implicated in obsessive–compulsive disorder
Atmaca, M., Yildirim, H., Ozdemir, H., Tezcan, E., & Kursad Poyraz, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.008 · Cited by 145 · see citing works
Szeszko, P. R., Christian, C., MacMaster, F., Lencz, T., Mirza, Y., Taormina, S. P., Easter, P., Rose, M., Michalopoulou, G. A., & Rosenberg, D. R. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08010033 · Cited by 143 · see citing works
Self-citationAmygdalar and hippocampal volume: A comparison between manual segmentation, Freesurfer and VBM
Grimm, O., Pohlack, S. T., Cacciaglia, R., Winkelmann, T., Plichta, M. M., Demirakça, T., & Flor, H. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.05.024 · Cited by 92 · see citing works
Volumetric MRI assessment of brain regions in patients with refractory obsessive-compulsive disorder
Atmaca, M., Yildirimb, H., Ozdemirb, H., Aydinb, A., Tezcana, E., & Ozlera, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.033 · Cited by 89 · see citing works
Rosenberg, D. R., Benazon, N. R., Gilbert, A., Sullivan, A., & Moore, G. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00902-1 · Cited by 87 · see citing works
Peng, Z., Lui, S. S. Y., Cheung, E. F. C., Jin, Z. H., Miao, G., Jin, J., & Chan, R. C. K. (2012) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2012.07.004 · Cited by 87 · see citing works
Selles, R. R., Storch, E. A., & Lewin, A. B. (2014) · Child Psychiatry & Human Development · doi:10.1007/s10578-014-0435-9 · Cited by 84 · see citing works
Enlargement of Thalamic Nuclei in Tourette Syndrome
Miller, A. M., Bansal, R., Hao, X., Sanchez‐Peña, J., Sobel, L. J., Liu, J., Xu, D., Hongtu Zhu, B., Chakravarty, M. M., Durkin, K., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.102 · Cited by 78 · see citing works
Gilbert, A. R., Keshavan, M. S., Diwadkar, V., Nutche, J., MacMaster, F., Easter, P. C., Buhagiar, C. J., & Rosenberg, D. R. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.011 · Cited by 70 · see citing works
Brain structural correlates of depressive comorbidity in obsessive–compulsive disorder
Cardoner, N., Soriano‐Mas, C., Pujol, J., Alonso, P., Harrison, B. J., Deus, J., Hernández‐Ribas, R., Menchón, J. M., & Vallejo, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.039 · Cited by 62 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Stein, D. J., Costa, D. L. C., Lochner, C., Miguel, E. C., Reddy, Y. C. J., Shavitt, R. G., van den Heuvel, O. A., & Simpson, H. B. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0102-3 · Cited by 895 · see citing works
Self-citationThompson, P. M., Jahanshad, N., Ching, C. R. K., Salminen, L. E., Thomopoulos, S. I., Bright, J. K., Baune, B. T., Bertolín, S., Bralten, J., Bruin, W. B., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0705-1 · Cited by 638 · see citing works
Self-citationStructural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study
Whelan, C. D., Altmann, A., Botía, J. A., Jahanshad, N., Hibar, D. P., Absil, J., Alhusaini, S., Alvim, M. K. M., Auvinen, P., Bartolini, E., et al. (2017) · Brain · doi:10.1093/brain/awx341 · Cited by 528 · see citing works
Self-citationLogue, M. W., van Rooij, S. J. H., Dennis, E. L., Davis, S. L., Hayes, J. P., Stevens, J. S., Densmore, M., Haswell, C. C., Ipser, J., Koch, S. B. J., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.006 · Cited by 487 · see citing works
Self-citationOpel, N., Goltermann, J., Hermesdorf, M., Berger, K., Baune, B. T., & Dannlowski, U. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.04.027 · Cited by 287 · see citing works
Boedhoe, P. S. W., Schmaal, L., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17050485 · Cited by 271 · see citing works
Self-citationAltered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets
Postema, M. C., van Rooij, D., Anagnostou, E. A., Arango, C., Auzias, G., Behrmann, M., Busatto, G. F., Calderoni, S., Calvo, R. M., Daly, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13005-8 · Cited by 268 · see citing works
Self-citationMackey, S., Allgaier, N. A., Chaarani, B., Spechler, P. A., Orr, C., Bunn, J., Allen, N. B., Nelly Alia-klein, A., Batalla, A., Blaine, S. K., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17040415 · Cited by 266 · see citing works
Self-citationRaduà, J., Vieta, E., Shinohara, R. T., Kochunov, P. V., Quidé, Y., Green, M. J., Weickert, C. S., Weickert, T. W., Bruggemann, J. M., Kircher, T. T. J., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116956 · Cited by 246 · see citing works
Self-citationSchmaal, L., Pozzi, E., Ho, T. C., van Velzen, L. S., Veer, I. M., Opel, N., Someren, E. J. W. V., Han, L. K. M., Aftanas, L., Aleman, A., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0842-6 · Cited by 246 · see citing works
Self-citationThe ENIGMA Toolbox: multiscale neural contextualization of multisite neuroimaging datasets
Larivière, S., Paquola, C., Park, B., Royer, J., Wang, Y., Benkarim, O. M., de Wael, R. V., Valk, S. L., Thomopoulos, S. I., Kirschner, M., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01186-4 · Cited by 234 · see citing works
Self-citationBoedhoe, P. S. W., van Rooij, D., Hoogman, M., Twisk, J. W. R., Schmaal, L., Abe, Y., Alonso, P., Ameis, S. H., Anikin, A., Anticevic, A., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19030331 · Cited by 201 · see citing works
Self-citationMapping brain asymmetry in health and disease through the ENIGMA consortium
Kong, X.-Z., Postema, M., Guadalupe, T., de Kovel, C., Boedhoe, P., Hoogman, M., Mathias, S., van Rooij, D., Schijven, D., Glahn, D., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.25033 · Cited by 182 · see citing works
Self-citationNorman, L. J., Taylor, S. F., Liu, Y., Radua, J., Chye, Y., De Wit, S. J., Huyser, C., Karahanoglu, F. I., Luks, T., Manoach, D., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.010 · Cited by 189 · see citing works
Self-citationFineberg, N. A., Apergis-Schoute, A. M., Vaghi, M. M. S., Banca, P., Gillan, C. M., Voon, V., Chamberlain, S. R., Cinosi, E., Reid, J. E., Shahper, S., et al. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx088 · Cited by 186 · see citing works
Radonjić, N. V., Hess, J., Rovira, P., Andreassen, O. A., Buitelaar, J. K., Ching, C. R. K., Franke, B., Hoogman, M., Jahanshad, N., McDonald, C. R., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01002-z · Cited by 162 · see citing works
Self-citationEarly intervention for obsessive compulsive disorder: An expert consensus statement
Fineberg, N. A., Dell'Osso, B., Albert, U., Maina, G., Geller, D., Carmi, L., Sireau, N., Walitza, S., Grassi, G., Pallanti, S., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.02.002 · Cited by 158 · see citing works
Self-citationChing, C. R. K., Hibar, D. P., Gurholt, T. P., Nunes, A., Thomopoulos, S. I., Abé, C., Agartz, I., Brouwer, R. M., Cannon, D. M., de Zwarte, S. M. C., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25098 · Cited by 143 · see citing works
Self-citationMuetzel, R. L., Blanken, L. M. E., van der Ende, J., Marroun, H. E., Shaw, P., Sudre, G. P., van der Lugt, A., Jaddoe, V. W. V., Verhulst, F. C., Tiemeier, H. W., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16070813 · Cited by 142 · see citing works
Genetics of obsessive-compulsive disorder
Mahjani, B., Bey, K., Boberg, J., & Burton, C. L. (2021) · Psychological Medicine · doi:10.1017/s0033291721001744 · Cited by 125 · see citing works
Ziegler, G., Hauser, T. U., Moutoussis, M., Bullmore, E. T., Goodyer, I. M., Fonagy, P., Jones, P. B., Lindenberger, U., & Dolan, R. J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0394-3 · Cited by 123 · see citing works
Segmentation of the hippocampus by transferring algorithmic knowledge for large cohort processing
Thyreau, B., Sato, K., Fukuda, H., & Taki, Y. (2017) · Medical Image Analysis · doi:10.1016/j.media.2017.11.004 · Cited by 113 · see citing works
Kong, X., Boedhoe, P. S. W., Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., Assogna, F., Baker, J. T., Batistuzzo, M. C., Benedetti, F., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.022 · Cited by 111 · see citing works
Self-citationObsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction
Jalal, B., Chamberlain, S. R., & Sahakian, B. J. (2023) · Brain and Behavior · doi:10.1002/brb3.3000 · Cited by 111 · see citing works
“Consistent with this expanded orbitofrontal striatal model, a worldwide meta-analysis of 1830 OCD patients and 1759 control subjects found smaller hippocampal volumes in patients (Boedhoe et al., 2017; such hippocampal volume might help explain visuospatial deficits in OCD discussed below).”
A General Primer for Data Harmonization
Cheng, C. I.-F., Messerschmidt, L., Bravo, I., Waldbauer, M., Bhavikatti, R., Schenk, C., Grujić, V., Model, T. A., Kubinec, R., & Barceló, J. (2024) · Scientific Data · doi:10.1038/s41597-024-02956-3 · Cited by 110 · see citing works
Boedhoe, P. S. W., Heymans, M. W., Schmaal, L., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., et al. (2019) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2018.00102 · Cited by 109 · see citing works
Self-citationDennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0631-x · Cited by 108 · see citing works
Self-citationCalzà, J., Gürsel, D. A., Schmitz-Koep, B., Bremer, B., Reinholz, L., Berberich, G., & Koch, K. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00319 · Cited by 99 · see citing works
“Comprehensive meta-analyses exploring functional or gray/ white matter structural alterations in OCD reported changes partly in regions of the CSTC, such as the pallidum (23), but also in areas and networks not directly pertaining to the CSTC, such as dorsomedial, dorsolateral, ventrolateral, and frontopolar prefronta…”
BackgroundSelf-citationThe reliability and heritability of cortical folds and their genetic correlations across hemispheres
Pizzagalli, F., Auzias, G., Yang, Q., Mathias, S. R., Faskowitz, J., Boyd, J., Amini, A., Rivière, D., McMahon, K. L., de Zubicaray, G. I., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01163-1 · Cited by 96 · see citing works
Self-citationvan den Heuvel, O. A., Boedhoe, P. S. W., Bertolín, S., Bruin, W. B., Francks, C., Ivanov, I., Jahanshad, N., Kong, X., Kwon, J. S., O’Neill, J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.24972 · Cited by 92 · see citing works
Self-citationBaribeau, D. A., Dupuis, A., Paton, T., Hammill, C. F., Scherer, S. W., Schachar, R. J., Arnold, P. D., Szatmári, P., Nicolson, R., Georgiades, S., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0382-0 · Cited by 91 · see citing works
Self-citationLiew, S., Zavaliangos‐Petropulu, A., Jahanshad, N., Lang, C. E., Hayward, K. S., Lohse, K. R., Juliano, J. M., Assogna, F., Baugh, L. A., Bhattacharya, A. K., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25015 · Cited by 85 · see citing works
Self-citationDuration of untreated illness and response to SRI treatment in Obsessive-Compulsive Disorder
Albert, U., Barbaro, F., Bramante, S., Rosso, G., Ronchi, D. D., & Maina, G. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2019.01.017 · Cited by 88 · see citing works
Hauser, T. U., Iannaccone, R., Dolan, R. J., Ball, J., Hättenschwiler, J., Drechsler, R., Rufer, M., Brandeis, D., Walitza, S., & Brem, S. (2017) · Psychological Medicine · doi:10.1017/s0033291716003305 · Cited by 86 · see citing works
Self-citationSethi, R., Gómez‐Coronado, N., Walker, A. J., Robertson, O. D., Agustini, B., Berk, M., & Dodd, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00605 · Cited by 88 · see citing works
Yun, J., Boedhoe, P. S. W., Vriend, C., Jahanshad, N., Abe, Y., Ameis, S. H., Anticevic, A., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., et al. (2020) · Brain · doi:10.1093/brain/awaa001 · Cited by 86 · see citing works
Self-citationBearden, C. E., & Thompson, P. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.033 · Cited by 84 · see citing works
Self-citationBruin, W. B., Abe, Y., Alonso, P., Anticevic, A., Backhausen, L. L., Balachander, S., Bargallo, N., Batistuzzo, M. C., Benedetti, F., Bertolin Triquell, S., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02077-0 · Cited by 81 · see citing works
Self-citationChing, C., Gutman, B., Sun, D.-Q., Reina, J. E. V., Ragothaman, A., Isaev, D., Zavaliangos-Petropulu, A., Lin, A., Jonas, R., Kushan, L., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19060583 · Cited by 77 · see citing works
Self-citationBruin, W. B., Taylor, L., Thomas, R. M., Shock, J. P., Zhutovsky, P., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01013-y · Cited by 99 · see citing works
Self-citationGleichgerrcht, E. L., Munsell, B. C., Alhusaini, S., Alvim, M. K. M., Bargalló, N., Bender, B., Bernasconi, A., Bernasconi, N., Bernhardt, B. C., Blackmon, K., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102765 · Cited by 77 · see citing works
Self-citationHu, X., Du, M., Chen, L., Li, L., Zhou, M., Zhang, L., Liu, Q., Lu, L., Mreedha, K., Huang, X., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.012 · Cited by 75 · see citing works
Narayanaswamy, J., Hazari, N., & Venkatasubramanian, G. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_525_18 · Cited by 75 · see citing works
Self-citationRasgon, A., Lee, W. H., Leibu, E., Laird, A., Glahn, D., Goodman, W., & Frangou, S. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.08.001 · Cited by 73 · see citing works
Picó‐Pérez, M., Moreira, P. S., Ferreira, V. D. M., Raduà, J., Mataix‐Cols, D., Sousa, N., Soriano‐Mas, C., & Morgado, P. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.033 · Cited by 71 · see citing works
Self-citationCotovio, G., Ventura, F., da Silva, D. R., Pereira, P., & Oliveira-Maia, A. J. (2023) · Brain Sciences · doi:10.3390/brainsci13071029 · Cited by 68 · see citing works
Sønderby, I. E., Ching, C. R. K., Thomopoulos, S. I., van der Meer, D., Sun, D., Villalon‐Reina, J. E., Agartz, I., Amunts, K., Arango, C., Armstrong, N. J., et al. (2022) · Human Brain Mapping · doi:10.1002/hbm.25354 · Cited by 67 · see citing works
Self-citationThe effect of childhood trauma on the severity of obsessive-compulsive symptoms: A systematic review
Destrée, L., Brierley, M., Albertella, L., Jobson, L., & Fontenelle, L. F. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.08.017 · Cited by 70 · see citing works
Sex is a defining feature of neuroimaging phenotypes in major brain disorders
Salminen, L. E., Tubi, M. A., Bright, J. K., Thomopoulos, S. I., Wieand, A., & Thompson, P. M. (2021) · Human Brain Mapping · doi:10.1002/hbm.25438 · Cited by 61 · see citing works
Self-citationPiras, F., Piras, F., Abe, Y., Agarwal, S. M., Anticevic, A., Ameis, S. H., Arnold, P. D., Banaj, N., Bargalló, N., Batistuzzo, M. C., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01276-z · Cited by 62 · see citing works
Self-citationOhi, K., Otowa, T., Shimada, M., Sasaki, T., & Tanii, H. (2020) · Psychological Medicine · doi:10.1017/s003329171900059x · Cited by 61 · see citing works
Jacobs, G. R., Voineskos, A. N., Hawco, C. S., Stefanik, L., Forde, N. J., Dickie, E. W., Lai, M., Szatmári, P., Schachar, R. J., Crosbie, J., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00902-6 · Cited by 60 · see citing works
Self-citationThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland, C. J., Kasprzak, S., de Joode, N. T., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., Balachander, S., Banaj, N., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01823-2 · Cited by 57 · see citing works
Self-citationNorman, L. J., Carlisi, C. O., Christakou, A., Murphy, C. M., Chantiluke, K. C., Giampietro, V., Simmons, A., Brammer, M. J., Mataix‐Cols, D., & Rubia, K. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.03.009 · Cited by 57 · see citing works
Self-citationBas‐Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., Jahanshad, N., Thomopoulos, S. I., Thompson, P. M., Veltman, D. J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25100 · Cited by 55 · see citing works
Self-citationAdhikari, B. M., Jahanshad, N., Shukla, D., Turner, J., Grotegerd, D., Dannlowski, U., Kugel, H., Engelen, J., Dietsche, B., Krug, A., et al. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9941-x · Cited by 53 · see citing works
Self-citationBruin, W. B., Denys, D. A. J. P., & van Wingen, G. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.005 · Cited by 53 · see citing works
Self-citationA comparison of methods to harmonize cortical thickness measurements across scanners and sites
Sun, D., Rakesh, G., Haswell, C. C., Logue, M. W., Baird, C. L., O’Leary, E. N., Cotton, A. S., Xie, H., Tamburrino, M., Chen, T., et al. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119509 · Cited by 49 · see citing works
Self-citationAn expert opinion on PANDAS/PANS: highlights and controversies
Chiarello, F., Spitoni, S., Hollander, E., Matucci Cerinic, M., & Pallanti, S. (2017) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2017.1285941 · Cited by 50 · see citing works
Thorsen, A. L., Kvale, G., Hansen, B. K. A., & van den Heuvel, O. A. (2018) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-018-0142-4 · Cited by 49 · see citing works
Koch, K., Reeß, T. J., Rus, O. G., Gürsel, D. A., Wagner, G., Berberich, G., & Zimmer, C. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00254 · Cited by 45 · see citing works
Self-citationNorman, L. J., Carlisi, C. O., Christakou, A., Cubillo, A., Murphy, C. M., Chantiluke, K. C., Simmons, A., Giampietro, V., Brammer, M. J., Mataix‐Cols, D., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.04.013 · Cited by 46 · see citing works
Self-citationLi, K., Zhang, H., Yang, Y., Zhu, J., Wang, B., Shi, Y., Li, X., Zhang, M., Lv, L., & Zhang, H. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111982 · Cited by 46 · see citing works
Han, S., Xu, Y., Guo, H., Fang, K., Wei, Y., Liu, L., Cheng, J., Zhang, Y., & Cheng, J. (2022) · Human Brain Mapping · doi:10.1002/hbm.25833 · Cited by 44 · see citing works
Moon, C., & Jeong, G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.059 · Cited by 41 · see citing works
Carlisi, C. O., & Robinson, O. J. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818774223 · Cited by 42 · see citing works
Cyr, M., Pagliaccio, D., Yanes-Lukin, P. K., Fontaine, M., Rynn, M. A., & Marsh, R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0613-3 · Cited by 41 · see citing works
Self-citationThompson, P. M., Jahanshad, N., Ching, C. R. K., Salminen, L. E., Thomopoulos, S. I., Bright, J. K., Baune, B. T., Bertolín, S., Bralten, J., Bruin, W. B., et al. (2019) · doi:10.31234/osf.io/qnsh7 · Cited by 41 · see citing works
Self-citationVeltman, D. J. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_209 · Cited by 40 · see citing works
Self-citationThe Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap
Szechtman, H., Harvey, B. H., Woody, E. Z., & Hoffman, K. L. (2019) · Pharmacological Reviews · doi:10.1124/pr.119.017772 · Cited by 40 · see citing works
Striatal abnormalities in trichotillomania: a multi-site MRI analysis
Isobe, M., Redden, S. A., Keuthen, N. J., Stein, D. J., Lochner, C., Grant, J. E., & Chamberlain, S. R. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2017.12.031 · Cited by 37 · see citing works
Self-citationNeurocircuit models of obsessive-compulsive disorder: limitations and future directions for research
Shephard, E., Batistuzzo, M. C., Hoexter, M. Q., Stern, E. R., Zuccolo, P. F., Ogawa, C. Y., da Silva, R. D. M. F., Brunoni, A. R., Costa, D. L. D. C., Doretto, V. F., et al. (2021) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-1709 · Cited by 38 · see citing works
Self-citationGroenewold, N. A., Bas-Hoogendam, J. M., Amod, A. R., Laansma, M. A., Van Velzen, L. S., Aghajani, M., Hilbert, K., Oh, H., Salas, R., Jackowski, A. P., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01933-9 · Cited by 36 · see citing works
Self-citationAssociation between hippocampus volume and symptom profiles in obsessive–compulsive disorder
Reeß, T. J., Rus, O. G., Gürsel, D. A., Schmitz‐Koep, B., Wagner, G., Berberich, G., & Koch, K. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.006 · Cited by 38 · see citing works
Self-citationOlsen, A., Babikian, T., Bigler, E. D., Caeyenberghs, K., Conde, V., Dams-O’Connor, K., Dobryakova, E., Genova, H. M., Grafman, J. H., Haberg, A. K., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00313-7 · Cited by 37 · see citing works
Self-citationViswanath, B., Rao, N. P., Narayanaswamy, J. C., Sivakumar, P. T., Kandasamy, A., Kesavan, M., Mehta, U. M., Venkatasubramanian, G., John, J. P., Mukherjee, O., et al. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1674-2 · Cited by 35 · see citing works
Self-citationYang, X., Hu, X., Tang, W., Li, B., Yang, Y., Gong, Q., & Huang, X. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.080 · Cited by 36 · see citing works
Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity
Wang, Y.-M., Zou, L., Xie, W.-L., Yang, Z., Zhu, X., Cheung, E. F. C., Sørensen, T. A., Møller, A., & Chan, R. C. K. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.03.009 · Cited by 32 · see citing works
A Clinical Staging Model for Obsessive–Compulsive Disorder: Is It Ready for Prime Time?
Fontenelle, L. F., & Yücel, M. (2019) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.01.014 · Cited by 34 · see citing works
Hu, X., Zhang, L., Bu, X., Li, H., Gao, Y., Lu, L., Tang, S., Wang, Y., Huang, X., & Gong, Q. (2020) · Depression and Anxiety · doi:10.1002/da.23008 · Cited by 34 · see citing works
Dentate gyrus volume deficit in schizophrenia
Nakahara, S., Turner, J. A., Calhoun, V. D., Lim, K. O., Mueller, B., Bustillo, J. R., O'Leary, D. S., McEwen, S., Voyvodic, J. T., Belger, A., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291719001144 · Cited by 33 · see citing works
Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder
Lamothe, H., Baleyte, J., Mallet, L., & Pélissolo, A. (2019) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2019-0471 · Cited by 31 · see citing works
Diagnostic Issues in Early-Onset Obsessive-Compulsive Disorder and their Treatment Implications
Burchi, E., & Pallanti, S. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180426151746 · Cited by 32 · see citing works
Mufford, M. S., Cheung, J. W., Jahanshad, N., van der Merwe, C., Ding, L., Groenewold, N. A., Koen, N., Chimusa, E. R., Dalvie, S., Ramesar, R., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0452-3 · Cited by 31 · see citing works
Self-citationWeeland, C. J., White, T. J. H., Vriend, C., Muetzel, R. L., Starreveld, J., Hillegers, M. H. J., Tiemeier, H. W., & van den Heuvel, O. A. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2020.03.012 · Cited by 31 · see citing works
Han, S., Xu, Y., Guo, H., Fang, K., Wei, Y., Liu, L., Cheng, J., Zhang, Y., & Cheng, J. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac163 · Cited by 31 · see citing works
Hu, X., Zhang, L., Bu, X., Li, H., Li, B., Tang, W., Lu, L., Hu, X., Tang, S., Gao, Y., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00122 · Cited by 31 · see citing works
Fajnerova, I., Gregus, D., Francova, A., Noskova, E., Koprivova, J., Stopkova, P., Hlinka, J., & Horacek, J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00568 · Cited by 30 · see citing works
Tondelli, M., Vaudano, A. E., Sisodiya, S. M., & Meletti, S. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00622 · Cited by 30 · see citing works
Niu, R., Du, M., Ren, J., Qing, H., Wang, X., Guohui, X., Lei, D., & Zhou, P. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00402-7 · Cited by 30 · see citing works
Kurhan, F., Hakan, H., Işık, M., & Atan, Y. S. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.2.240 · Cited by 30 · see citing works
Bruin, W. B., Taylor, L., Thomas, R. M., Shock, J. P., Zhutovsky, P., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., et al. (2019) · medRxiv · doi:10.1101/19012567 · Cited by 30 · see citing works
Self-citationEthical issues in global neuroimaging genetics collaborations
Palk, A. C., Illes, J., Thompson, P. M., & Stein, D. J. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117208 · Cited by 29 · see citing works
Self-citationJia, C., Ou, Y., Chen, Y., Li, P., Lv, D., Yang, R., Zhong, Z., Sun, L., Wang, Y., Zhang, G., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.559729 · Cited by 28 · see citing works
Thalamic Subregions and Obsessive-Compulsive Symptoms in 2,500 Children From the General Population
Weeland, C. J., Vriend, C., van der Werf, Y. D., Huyser, C., Hillegers, M. H. J., Tiemeier, H. W., White, T. J. H., & van den Heuvel, O. A. (2021) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2021.05.024 · Cited by 28 · see citing works
Self-citationLei, H., Lai, J., Sun, X., Xu, Q., & Feng, G. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180032 · Cited by 26 · see citing works
Challenges and Opportunities in dMRI Data Harmonization
Zhu, A. H., Moyer, D., Nir, T. M., Thompson, P. M., & Jahanshad, N. (2019) · Mathematics and visualization · doi:10.1007/978-3-030-05831-9_13 · Cited by 27 · see citing works
Self-citationRus, O. G., Reeß, T. J., Wagner, G., Zaudig, M., Zimmer, C., & Koch, K. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170030 · Cited by 26 · see citing works
Self-citationPerceived emotion regulation and emotional distress tolerance in patients with hoarding disorder
Worden, B. L., Levy, H. C., Das, A., Katz, B. W., Stevens, M. C. G., & Tolin, D. F. (2019) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2019.100441 · Cited by 27 · see citing works
Self-citationSubcortical Brain Alterations in Carriers of Genomic Copy Number Variants
Kumar, K., Modenato, C., Moreau, C. A., Ching, C. R. K., Harvey, A., Martin‐Brevet, S., Huguet, G., Jean‐Louis, M., Douard, E. A., Martin, C.-O., et al. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20220304 · Cited by 26 · see citing works
Self-citation
- Authors
- Boedhoe, P. S. W., Schmaal, L., Abe, Y., Ameis, S. H., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Calvo, A., Cheng, Y., Cho, K. I. K., Dallaspezia, S., Denys, D., Fitzgerald, K. D., Fouche, J.-P., Giménez, M., Gruner, P., Hanna, G. L., Hibar, D. P., Hoexter, M. Q., Hu, H., Huyser, C., Ikari, K., Jahanshad, N., Kathmann, N., Kaufmann, C., Koch, K., Kwon, J. S., Lazaro, L., Liu, Y., Lochner, C., Marsh, R., Martínez-Zalacaín, I., Mataix-Cols, D., Menchón, J. M., Minuzzi, L., Nakamae, T., Nakao, T., Narayanaswamy, J. C., Piras, F., Piras, F., Pittenger, C., Reddy, Y. C. J., Sato, J. R., Simpson, H. B., Soreni, N., Soriano-Mas, C., Spalletta, G., Stevens, M. C., Szeszko, P. R., Tolin, D. F., Venkatasubramanian, G., Walitza, S., Wang, Z., van Wingen, G. A., Xu, J., Xu, X., Yun, J.-Y., Zhao, Q., ENIGMA OCD Working Group, Thompson, P. M., Stein, D. J., van den Heuvel, O. A., The members of the ENIGMA OCD Working Group, Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., Bargalló, N., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Boedhoe, P. S. W., Bollettini, I., Bose, A., Brem, S., Busatto, G. F., Calvo, A., Calvo, R., Cath, D. C., Cheng, Y., Cho, K. I. K., Dallaspezia, S., de Vries, F. E., de Wit, S. J., Denys, D., Fang, Y., Fitzgerald, K. D., Fontaine, M., Fouche, J.-P., Giménez, M., Gruner, P., Hanna, G. L., Hibar, D. P., Hoexter, M. Q., Hu, H., Huyser, C., Ikari, K., Jahanshad, N., Kathmann, N., Kaufmann, C., Khadka, S., Koch, K., Kwon, J. S., Lazaro, L., Liu, Y., Lochner, C., Marsh, R., Martínez-Zalacaín, I., Mataix-Cols, D., Menchón, J. M., Miguel, E. C., Minuzzii, L., Morer, A., Nakamae, T., Nakao, T., Narayanaswamy, J. C., Piras, F., Piras, F., Pittenger, C., Reddy, Y. C. J., Sato, J. R., Simpson, H. B., Schmaal, L., Soreni, N., Soriano-Mas, C., Spalletta, G., Stein, D. J., Stevens, M. C., Szeszko, P. R., Thompson, P. M., Tolin, D. F., Veltman, D. J., Venkatasubramanian, G., van den Heuvel, O. A., van der Werf, Y. D., van Wingen, G. A., Walitza, S., Wang, Z., Xu, J., Xu, X., Yun, J.-Y., & Zhao, Q.
- Affiliations
- Hospital for Sick Children (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- Venue
- American Journal of Psychiatry
- Published
- 2017-01-01
- Volume
- 174
- Issue
- 1
- Pages
- 60-69
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC5344782
- OpenAlex
- W2517818012
- Cited by
- 335
- References
- 38
- Citations by year
- 2026: 28 · 2025: 20 · 2024: 24 · 2023: 29 · 2022: 37 · 2021: 41 · 2020: 55 · 2019: 50 · 2018: 25 · 2017: 25 · 2016: 1
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Bristol-Myers Squibb
- Eli Lilly and Company
- GlaxoSmithKline
- Yale University
- University of Southern California
- International OCD Foundation
- Hamilton Health Sciences
- Ontario Brain Institute
- Wellcome Trust (U54 EB020403, 064846)
- Canadian Network for Mood and Anxiety Treatments
- National Institute of Mental Health and Neurosciences
- Universidade Federal do ABC
- University of Cambridge
- Department of Biotechnology, Ministry of Science and Technology, India (BT/06/IYBA/2012., 500236/ Z/11/Z)
- Department of Science and Technology, Ministry of Science and Technology, India (IFA 12-LSBM 26, /PR13334/Med/30/259/2009, DST INSPIRE faculty grant -IFA12-LSBM-26, IFA-12)
- Deutsche Forschungsgemeinschaft (U54 EB020403, KO 3744/2-1)
- Ministry of Education, Culture, Sports, Science and Technology (26461753)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (130237, 320030)
- Koninklijke Nederlandse Akademie van Wetenschappen
- Universiteit van Amsterdam
- Bundesministerium für Bildung und Forschung (U54 EB020403)
- Seoul National University
- Ministero della Salute
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (917-15-318)
- Kunming Medical University
- Karolinska Institutet
- Ministerio de Ciencia e Innovación
- Shanghai Jiao Tong University
- Universidade de São Paulo
- Technische Universität München
- Universitat de Barcelona
- Hospital for Sick Children
- Humboldt-Universität zu Berlin
- Universität Zürich
- Centro de Investigación Biomédica en Red de Salud Mental
- University of Cape Town
- The Wellcome Trust DBT India Alliance (500236/Z/11/Z)
- Universitat Autònoma de Barcelona
- Servier
- H. Lundbeck A/S
- Hamilton Health Sciences Foundation
- National Institutes of Health (12-13, EB020403, UL1TR001863)
- Mathison Centre for Mental Health Research and Education
- Cumming School of Medicine, University of Calgary
- College of Medicine, Seoul National University
- Canadian Institutes of Health Research
- Medical Research Council (U54 EB020403)
- Japan Society for the Promotion of Science (26461753)
- Agència de Gestió d'Ajuts Universitaris i de Recerca (2014 SGR 1672)
- Instituto de Salud Carlos III (PI13/01958, PI14/00413, PI14/, PI13/00918, PI040829, CP10/00604)
- School of Medicine, Shanghai Jiao Tong University
- European Regional Development Fund (PI14/00413, PI13/01958)
- National Institute of Mental Health (R01MH101493, R21MH093889, R01MH085321)
- National Institute of Biomedical Imaging and Bioengineering (U54EB020403)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, subcortical volume, hippocampus, globus pallidus, thalamus, pediatric OCD, neuroplasticity, antipsychotic effects, brain structure
- MeSH terms
- Adolescent, Adult, Child, Globus Pallidus, Hippocampus, Humans, Magnetic Resonance Imaging, Middle Aged, Obsessive-Compulsive Disorder, Organ Size, Thalamus, Young Adult, Neuroimaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
