Cited by 429Mental Health Treatment and AccessHealth Policy Implementation SciencePsychotherapy Techniques and Applications

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Collaborative care for depression in primary care: Making sense of a complex intervention: systematic review and meta-regression

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Bower, Peter, Gilbody, Simon, Richards, David, Fletcher, Janine, Sutton, Alex·2006·British Journal of Psychiatry

DOI 10.1192/bjp.bp.106.023655

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Abstract

Background: The management of depression in primary care is a significant issue for health services worldwide. ‘Collaborative care’ interventions are effective, but little is known about which aspects of these complex interventions are essential. Aims: To use meta-regression to identify ‘active ingredients' in collaborative care models for depression in primary care. Method: Studies were identified using systematic searches of electronic databases. The content of collaborative care interventions was coded, together with outcome data on antidepressant use and depressive symptoms. Meta-regression was used to examine relationships between intervention content and outcomes. Results: There was no significant predictor of the effect of collaborative care on antidepressant use. Key predictors of depressive symptom outcomes included systematic identification of patients, professional background of staff and specialist supervision. Conclusions: Meta-regression may be useful in examining ‘active ingredients' in complex interventions in mental health.

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Background
How should meta‐regression analyses be undertaken and interpreted?
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Authors: Bower, P., Gilbody, S., Richards, D., Fletcher, J., & Sutton, A.
Affiliations: University of Manchester (GB)
University of York (GB)
University of Leicester (GB)
Corresponding author: Bower, Peter
ORCID: Bower, Peter
Gilbody, Simon
Richards, David
Sutton, Alex
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2006-12
Volume: 189
Issue: 6
Pages: 484-493
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.106.023655
OpenAlex: W2114487236
Cited by: 429
References: 82
Citations by year: 2026: 4 · 2025: 7 · 2024: 17 · 2023: 6 · 2022: 12 · 2021: 22 · 2020: 23 · 2019: 15 · 2018: 12 · 2017: 28 · 2016: 18 · 2015: 33 · 2014: 51 · 2013: 29 · 2012: 34
FWCI: 2.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 4050 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Medical Research Council
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: collaborative care, depression, primary care, complex interventions, active ingredients, antidepressant use, depressive symptoms, mental health services
MeSH terms: Depressive Disorder, Humans, Interprofessional Relations, Mental Health Services, Patient Care Team, Primary Health Care, Treatment Outcome

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Collaborative care for depression in primary care: Making sense of a complex intervention: systematic review and meta-regression

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