The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Risk of hip fracture in patients with a history of schizophrenia
Open accessAbstract
Background: There is evidence of an association between decreased bone mineral density schizophrenia, and prolactin-raising antipsychotic medication. However, it is not known whether this is clinically significant. Aims: To investigate whether patients with a history of schizophrenia are at increased risk of hip fracture. Method: In a case-control study, we compared cases of ‘hip fracture’ on the General Practice Research Database (n=16 341) with matched controls (n=29 889). Results: Hip fracture was associated with schizophrenia (OR=1.73; 95% CI 1.32-2.28), and prolactin-raising antipsychotics (OR=2.6; 95% CI 2.432.78), in the univariate analysis. In the multivariate analysis, prolactin-raising antipsychotics were independently associated with hip fracture but schizophrenia was not. A significant interaction between gender and antipsychotics was found in the association with hip fracture (P=0.042); OR=2.12 (95% C11.73-2.59)for men, OR=l.93 (95% C11.78-2.10) for women. Conclusions: The association between prolactin-raising antipsychotic medication and hip fracture may have serious implications for public health. Mental health service patients may require preventive measures including dietary and lifestyle advice.
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“Other studies (506-510) have found significant increases (OR=1.2-2.6) in the risk of fractures associated with AP.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [506]
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Cites
Use of Inhaled Corticosteroids and Risk of Fractures
van Staa, T. P., Leufkens, H. G. M., & Cooper, C. C. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.3.581 · Cited by 1,297
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Endogenous Hormones and the Risk of Hip and Vertebral Fractures among Older Women
Cummings, S. R., Browner, W. S., Bauer, D. C., Stone, K. L., Ensrud, K. E., Jamal, S. A., & Ettinger, B. B. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809103391104 · Cited by 660
The Treatment of Unrelated Disorders in Patients with Chronic Medical Diseases
Redelmeier, D. A., Tan, S. H., & Booth, G. L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805213382106 · Cited by 634
The UK General Practice Research Database
Walley, T., & Mantgani, A. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04248-7 · Cited by 624
Jenkins, R., Lewis, G., Bebbington, P., Brugha, T. S., Farrell, M., GILL, B., & Meltzer, H. (1997) · Psychological Medicine · doi:10.1017/s0033291797005308 · Cited by 427
Morbidity and Rate of Undiagnosed Physical Illnesses in a Psychiatric Clinic Population
Koranyi, E. K. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780040056006 · Cited by 409
Causes and Consequences of the Gender Difference in Age at Onset of Schizophrenia
Häfner, H., der Heiden, W. A., Behrens, S., Gattaz, W. F., Hambrecht, M., Loffler, W., Maurer, K., Munk‐Jørgensen, P., Nowotny, B., Riecher‐Rössler, A., et al. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033317 · Cited by 333
Antipsychotic Drugs: A New Risk Factor for Osteoporosis in Young Women With Schizophrenia?
O'Keane, V., & Meaney, A. M. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000150223.31007.e0 · Cited by 307
Cumming, R. G., Nevitt, M. C., & Cummings, S. R. (1997) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a017956 · Cited by 296
Research works printed but not linked: 1
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DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488
“Other studies (506-510) have found significant increases (OR=1.”
BackgroundGoodwin, G., Haddad, P. M., Ferrier, I. N., Aronson, J., Barnes, T., Cipriani, A., Coghill, D., Fazel, S., Geddes, J. R., Grunze, H., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636545 · Cited by 1,343
“Decreased BMD and increased fracture risk have been shown in patients with severe mental illness (Howard et al., 2007; Meyer and Koro, 2004; Lehman and Meyer, 2005).”
Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review
Ochoa, S., Usall, J., Cobo, J., Labad, X., & Kulkarni, J. (2012) · Schizophrenia Research and Treatment · doi:10.1155/2012/916198 · Cited by 735
“One case-control study investigated whether potential treatment-emergent decreases in bone mineral density could confer an increased risk of hip fractures in patients with a history of schizophrenia [87].”
BackgroundManagement of common adverse effects of antipsychotic medications
Stroup, T. S., & Gray, N. (2018) · World Psychiatry · doi:10.1002/wps.20567 · Cited by 572
Hippisley‐Cox, J., & Coupland, C. A. C. (2009) · BMJ · doi:10.1136/bmj.b4229 · Cited by 493
Metadata
- Authors
- Howard, L., Kirkwood, G., & Leese, M.
- Affiliations
- King's College London (GB)
- Corresponding author
- Howard, Louise
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2007-02
- Volume
- 190
- Issue
- 2
- Pages
- 129-134
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2166620991
- Cited by
- 158
- References
- 29
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 5 · 2014: 11 · 2013: 15 · 2012: 15
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- hip fracture, schizophrenia, bone mineral density, fracture risk, sex differences, fracture prevention, psychiatric patients
- MeSH terms
- Accidental Falls, Female, Hip Fractures, Humans, Male, Prolactin, Risk Factors, Schizophrenia, Antipsychotic Agents, Bone Density, Case-Control Studies
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